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The role of the nucleus reuniens in the temporal organization of memory andbehavior

Award Number: R01MH113626
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/10/2018
PERIOD OF PERFORMANCE END DATE: 02/29/2024

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The role of the nucleus reuniens in the temporal organization of memory andbehavior - PROJECT SUMMARY/ABSTRACT Temporal organization is critical to many perceptual, cognitive, and behavioral functions. These temporal abilities are adversely impacted in several mental health disorders including, but not limited to, schizophrenia and attention-deficit disorder (ADHD). However, the neurobiological underpinnings of the temporal organization of memory and behavior remain poorly understood. Here, we will focus on the nucleus reuniens of the thalamus (RE), an understudied brain region at the nexus of communication between the hippocampus and medial prefrontal cortex. RE is anatomically positioned to profoundly influence interactions between memory and executive systems in the brain. Based on anatomical and theoretical considerations, we hypothesize that RE is essential to, and RE neurons represent, sequences of events and elapsed time. However, nothing is known about the role of RE in time and temporal contexts. In this project, we will directly test the role of RE in time and temporal contexts in memory and behavior. We will use a broad behavioral strategy testing three different fundamental timing tasks: AIM1, memory for sequences of events; AIM2, elapsed-time memory (scale = minutes); and AIM3, interval timing (scale = tens of seconds). One experimental approach will be to test the causal role of RE, and RE circuitry, using muscimol and state-of-the-art virally-delivered inhibitory designer receptors exclusively activated by designer drugs (DREADDs). In another approach, we will record RE neural activity—neurons, ensembles, and local field potentials—using cutting-edge driveable tetrode arrays. Completion of these aims will establish foundational knowledge for understanding the role of the RE in the temporal organization of memory and behavior. Importantly, we will integrate our findings into a unified theoretical framework for RE circuitry within a medial prefrontal cortex-reuniens-hippocampus system. What we learn from these studies will lead to new approaches in the study of temporal dysfunctions that occur in numerous mental health disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$67 )
2024	2022	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Mental Health Research Grants	000	5	6/18/2024	NON-COMPETING CONTINUATION	-$67
														Subtotal = -$67

Issue Date FY: 2022 ( Subtotal = $363,838 )
2022	2022	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Mental Health Research Grants	001	5	5/12/2022	NON-COMPETING CONTINUATION	$36,384
2022	2022	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Mental Health Research Grants	000	5	2/25/2022	NON-COMPETING CONTINUATION	$327,454
														Subtotal = $363,838

Issue Date FY: 2021 ( Subtotal = $471,056 )
2021	2021	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Mental Health Research Grants	000	4	2/5/2021	NON-COMPETING CONTINUATION	$471,056
														Subtotal = $471,056

Issue Date FY: 2020 ( Subtotal = $471,301 )
2020	2020	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Mental Health Research Grants	000	3	2/19/2020	NON-COMPETING CONTINUATION	$364,341
2020	2020	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Mental Health Research Grants	001	3	2/20/2020	SUPPLEMENT FOR EXPANSION	$106,960
														Subtotal = $471,301

Issue Date FY: 2019 ( Subtotal = $364,575 )
2019	2019	FLORIDA INTERNATIONAL UNIVERSITY	11200 S W 8TH ST MARC 430	MIAMI	FL	33199	MIAMI-DADE	USA	Mental Health Research Grants	000	2	2/6/2019	NON-COMPETING CONTINUATION	$364,575
														Subtotal = $364,575

Issue Date FY: 2018 ( Subtotal = $368,998 )
2018	2018	FLORIDA INTERNATIONAL UNIVERSITY	11200 S W 8TH ST MARC 430	MIAMI	FL	33199	MIAMI-DADE	USA	Mental Health Research Grants	000	1	5/10/2018	NEW	$368,998
														Subtotal = $368,998

Grand Total All Awards = $2,039,701

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The role of the nucleus reuniens in the temporal organization of memory andbehavior

Award Number: R01MH113626

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/10/2018

PERIOD OF PERFORMANCE END DATE: 02/29/2024

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