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Functional imaging of cortico-limbic predictors of emotion regulation, emotion reactivity, and risk for suicidal ideation and behavior

Award Number: R01MH112674
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract Suicide rates are on the rise, and recent investments in treatment and intervention have done little to turn the tide. While studies have identified cross-sectional predictors of suicidal ideation and behavior (e.g. age, gender, psychiatric diagnosis), the processes that underpin episodic suicide risk – that is, episodes of suicidal ideation and behavior as they occur in the real world – remain poorly understood. Neuroimaging studies examining structural and functional alterations present in individuals with suicidal ideation (SI) and behavior (SB) have implicated elements of a fronto-striato-amygdala circuit underlying executive control and emotion processing as conferring suicide risk. This circuit involves key regions of interest (ROIs) including the dorsolateral prefrontal cortex (dlPFC), ventral medial PFC (vmPFC)/orbitofrontal cortex (OFC), and projections to the thalamus, amygdala, hippocampus, caudate, and frontotemporal-striatum. This neural circuit may moderate emotional response through an opponent process model of reactivity to, and regulation of, emotional experiences. Specifically, initial reactivity to emotion involves bottom-up information processing from sensorimotor inputs to the amygdala and, ultimately, to the anterior cingulate cortex (ACC) and associated ROIs. Conversely, regulation of emotional experiences involves top-down information processing, effortful control, higher cognition, and executive functioning, originating in the PFC and associated ROIs. Our team (1R01MH095786), is developing an emotion reactivity translational endophenotype for suicide integrating genetics, psychophysiological monitoring coupled to an emotion reactivity task (i.e. Paced Audio Serial Addition Task), and real-world symptom and experiential sampling via ecological momentary assessment (EMA). Preliminary findings suggest that participants who have made a suicide attempt (SA) show greater anger reactivity during the most stressful part of the PASAT as compared to participants with SI; this response may represent a novel emotion reactivity marker of suicide risk. We believe that an important next step in understanding emotion reactivity in suicide is to examine the fronto-striato-amygdala top-down/bottom-up information-processing model using functional neuroimaging in association with laboratory-based and real-world measures (i.e. ecological momentary assessment) of emotion reactivity and regulation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$279,414 )
2025	2021	BUTLER HOSPITAL	345 BLACKSTONE BLVD STE 2	PROVIDENCE	RI	02906	PROVIDENCE	USA	Mental Health Research Grants	000	5	10/18/2024	NON-COMPETING CONTINUATION	-$279,414
														Subtotal = -$279,414

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	BUTLER HOSPITAL	345 BLACKSTONE BLVD	PROVIDENCE	RI	02906	PROVIDENCE	USA	Mental Health Research Grants	000	5	6/7/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $516,163 )
2021	2021	BUTLER HOSPITAL	345 BLACKSTONE BLVD	PROVIDENCE	RI	02906	PROVIDENCE	USA	Mental Health Research Grants	001	5	5/24/2021	NON-COMPETING CONTINUATION	$516,163
2021	2020	BUTLER HOSPITAL	345 BLACKSTONE BLVD	PROVIDENCE	RI	02906	PROVIDENCE	USA	Mental Health Research Grants	000	4	12/7/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $516,163

Issue Date FY: 2020 ( Subtotal = $564,378 )
2020	2020	BUTLER HOSPITAL	345 BLACKSTONE BLVD	PROVIDENCE	RI	02906	PROVIDENCE	USA	Mental Health Research Grants	000	4	5/26/2020	NON-COMPETING CONTINUATION	$564,378
														Subtotal = $564,378

Issue Date FY: 2019 ( Subtotal = $594,349 )
2019	2019	BUTLER HOSPITAL	345 BLACKSTONE BLVD	PROVIDENCE	RI	02906	PROVIDENCE	USA	Mental Health Research Grants	000	3	6/3/2019	NON-COMPETING CONTINUATION	$594,349
														Subtotal = $594,349

Issue Date FY: 2018 ( Subtotal = $716,192 )
2018	2018	BUTLER HOSPITAL	345 BLACKSTONE BLVD	PROVIDENCE	RI	02906	PROVIDENCE	USA	Mental Health Research Grants	000	2	6/12/2018	NON-COMPETING CONTINUATION	$574,592
2018	2018	BUTLER HOSPITAL	345 BLACKSTONE BLVD	PROVIDENCE	RI	02906	PROVIDENCE	USA	Mental Health Research Grants	001	2	9/10/2018	SUPPLEMENT FOR EXPANSION	$141,600
														Subtotal = $716,192

Issue Date FY: 2017 ( Subtotal = $623,590 )
2017	2017	BUTLER HOSPITAL	345 BLACKSTONE BLVD	PROVIDENCE	RI	02906	PROVIDENCE	USA	Mental Health Research Grants	000	1	8/8/2017	NEW	$623,590
														Subtotal = $623,590

Grand Total All Awards = $2,735,258

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Functional imaging of cortico-limbic predictors of emotion regulation, emotion reactivity, and risk for suicidal ideation and behavior

Award Number: R01MH112674

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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