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Development and validation of empirical models of the neuronal population activity underlying non-invasive human brain measurements

Award Number: R01MH111417
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary / Abstract A major obstacle in the study of human brain function is that we currently have limited understanding of how the measurements made by different instruments, such as fMRI and EEG, relate to one another and to the underlying neuronal circuitry. Significant efforts have led to development of models within various specialist fields, but fragmentation has held us back from advancing our interpretation of the spatiotemporal characteristics of non-invasive imaging signals. Bringing together the various models that pertain to signal interpretation would constitute a significant advance in what we can learn from non-invasive neuroimaging. In this project we take such an integrative approach to the study of cortical sensory systems. We intend to develop a set of connecting, empirically driven models that will predict how sensory stimuli are encoded in neuronal population activity underlying electrophysiological measures (AIM 1), and hemodynamic measures (AIM 2), leading to a comprehensive integrative model (AIM 3). The pivotal integrative model (AIM 3) will improve our understanding of, and revolutionize the information we can obtain from fMRI, the modality with the highest potential for mapping detailed functions non-invasively in humans. To achieve this we will combine hemodynamic and electrophysiological measurements at multiple spatial scales in humans, and in rodents at very high resolutions. This will include non-invasive (fMRI at 3T and 7T, MEG and EEG) and invasive (optical imaging, ECoG) modalities obtained from healthy humans. By obtaining multiple modality recordings from the same individuals, using the same stimuli and tasks, we will be able to unequivocally link clear and specific electrophysiological information to widely used fMRI technology, while significantly improving our understanding of the electrical and hemodynamic phenomena underlying brain activity. The research constitutes a multicenter endeavor to A) develop a comprehensive model to link external inputs to neuronal population physiology to non-invasive imaging measures, B) obtain state of the art multimodal recordings from the same individuals in order to bridge modalities and inform the models, C) validate the models with data from multiple modalities (ECoG, fMRI, MEG/EEG, optical recordings) and brain systems (visual, somatosensory and motor), and D) make algorithms and data available to the neuroscience community to foster further development beyond the project's lifetime. Moreover, the research will foster reconciliation of different theories about the relation between electrophysiology and fMRI and will lead to `breakthroughs in understanding the dynamic activity of the human brain'. Such breakthroughs will be essential in improving disease models of the nervous system, which rely on inferences about neuronal population activity from non-invasive imaging of human brain activity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$11,919 )
2024	2020	UNIVERSITAIR MEDISCH CENTRUM UTRECHT	HEIDELBERGLAAN, 100	UTRECHT				NLD	Mental Health Research Grants	000	5	2/16/2024	NON-COMPETING CONTINUATION	-$11,919
														Subtotal = -$11,919

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	UNIVERSITAIR MEDISCH CENTRUM UTRECHT	HEIDELBERGLAAN 100	UTRECHT				NLD	Mental Health Research Grants	000	5	4/26/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $750,652 )
2020	2020	UNIVERSITAIR MEDISCH CENTRUM UTRECHT	HEIDELBERGLAAN 100	UTRECHT	UTRECHT	3584 CX		NLD	Mental Health Research Grants	000	5	6/24/2020	NON-COMPETING CONTINUATION	$750,652
														Subtotal = $750,652

Issue Date FY: 2019 ( Subtotal = $815,224 )
2019	2019	UNIVERSITAIR MEDISCH CENTRUM UTRECHT	HEIDELBERGLAAN 100	UTRECHT	UTRECHT	3584 CX		NLD	Mental Health Research Grants	000	4	7/10/2019	NON-COMPETING CONTINUATION	$815,224
														Subtotal = $815,224

Issue Date FY: 2018 ( Subtotal = $949,749 )
2018	2018	UNIVERSITAIR MEDISCH CENTRUM UTRECHT	HEIDELBERGLAAN 100	UTRECHT	UTRECHT	3584 CX		NLD	Mental Health Research Grants	000	3	6/9/2018	NON-COMPETING CONTINUATION	$949,749
														Subtotal = $949,749

Issue Date FY: 2017 ( Subtotal = $973,863 )
2017	2017	UNIVERSITAIR MEDISCH CENTRUM UTRECHT	HEIDELBERGLAAN 100	UTRECHT	UTRECHT	3584 CX		NLD	Mental Health Research Grants	000	2	6/6/2017	NON-COMPETING CONTINUATION	$880,732
2017	2017	UNIVERSITAIR MEDISCH CENTRUM UTRECHT	HEIDELBERGLAAN 100	UTRECHT	UTRECHT	3584 CX		NLD	Mental Health Research Grants	001	2	7/28/2017	SUPPLEMENT FOR EXPANSION	$93,131
														Subtotal = $973,863

Issue Date FY: 2016 ( Subtotal = $887,937 )
2016	2016	UTRECHT UNIVERSITY MEDICAL SCHOOL	HEIDELBERGLAAN 100 3584 CG	UTRECHT				NLD	Mental Health Research Grants	000	1	9/22/2016	NEW	$887,937
														Subtotal = $887,937

Grand Total All Awards = $4,365,506

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Development and validation of empirical models of the neuronal population activity underlying non-invasive human brain measurements

Award Number: R01MH111417

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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