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Transcription factor function in healthy and psychiatric disorder-affected brains

Award Number: R01MH110472
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2017
PERIOD OF PERFORMANCE END DATE: 05/31/2023

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Transcription factor function in healthy and psychiatric disorder-affected brains - PROJECT SUMMARY/ABSTRACT The goal of this R01 proposal is to probe deeply into the regulatory processes that underlie biological diversity within brain tissue samples from individuals free of psychiatric disorder and individuals with bipolar disorder, schizophrenia, or major depressive disorder. This proposal combines unique experimental and analytical innovations and a high-quality data production pipeline. High-quality dissected tissue from 9 anatomical sub- regions from each of 4 post-mortem human brains free of psychiatric disease will be analyzed, along with neuronal cell lines from 4 individuals collected by PsychENCODE investigators. Genome-wide binding profiles from “ChIP-seq” experiments for 100 transcription factors will be measured across these tissue and cell types. In addition, 6 of the key transcription factors will be analyzed in 2 brain regions from 96 individuals, including individuals that were free of psychiatric disease (n=24) or had bipolar disorder (n=24), schizophrenia (n=24), or major depressive disorder (n=24. These data will be used to assess the hypothesis that differential transcription factor activity contributes directly to the risk and manifestation of disease, and is motivated by previous observations from our groups of disease-associated transcriptional changes in brain tissue. Further, integrative analyses of all these data, along with measurements of transcripts, DNA methylation, and other data types that will be generated, will greatly enhance our understanding of the functional variability between people and across different brain regions within a given person. These data will furthermore result in the characterization of differences between healthy and disorder-affected individuals that may point to genes and pathways that are of special diagnostic, prognostic, or therapeutic value. Finally, these data will be shared to the greatest extent possible to substantially expand the depth and quality of brain tissue data resources accessible to the broader research community to reduce the medical burden of psychiatric disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Mental Health Research Grants	000	5	2/2/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $1,141,905 )
2021	2021	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Mental Health Research Grants	000	5	6/22/2021	NON-COMPETING CONTINUATION	$1,141,905
														Subtotal = $1,141,905

Issue Date FY: 2020 ( Subtotal = $1,141,905 )
2020	2020	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Mental Health Research Grants	000	4	5/19/2020	NON-COMPETING CONTINUATION	$1,141,905
														Subtotal = $1,141,905

Issue Date FY: 2019 ( Subtotal = $1,374,474 )
2019	2019	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Mental Health Research Grants	000	3	6/15/2019	NON-COMPETING CONTINUATION	$1,142,486
2019	2019	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Mental Health Research Grants	001	3	7/30/2019	SUPPLEMENT FOR EXPANSION	$231,988
														Subtotal = $1,374,474

Issue Date FY: 2018 ( Subtotal = $1,169,270 )
2018	2018	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Mental Health Research Grants	000	2	5/22/2018	NON-COMPETING CONTINUATION	$1,169,270
														Subtotal = $1,169,270

Issue Date FY: 2017 ( Subtotal = $1,125,538 )
2017	2017	HUDSON-ALPHA INSTITUTE FOR BIOTECHNOLOGY	601 GENOME WAY	HUNTSVILLE	AL	35806	MADISON	USA	Mental Health Research Grants	000	1	7/14/2017	NEW	$1,125,538
														Subtotal = $1,125,538

Grand Total All Awards = $5,953,092

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Transcription factor function in healthy and psychiatric disorder-affected brains

Award Number: R01MH110472

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2017

PERIOD OF PERFORMANCE END DATE: 05/31/2023

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