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Unobtrusive Sensing of Medication Intake ("USE-MI")

Award Number: R01MH109319
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/25/2015
PERIOD OF PERFORMANCE END DATE: 06/30/2022

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Unobtrusive Sensing of Medication Intake ("USE-MI") - DESCRIPTION (provided by applicant): Here, we seek to combine smartphone, "wearable device" and near-field communication technologies in a novel, integrated, unobtrusive system to improve individual adherence to anti-retroviral therapy (ART) and Pre- exposure prophylaxis (PrEP) for the treatment and prevention, respectively, of HIV infection. HIV treatment and PrEP require high levels of medication adherence sustained over many years to achieve optimal outcomes. Research on interventions to improve medication adherence, to date, has produced at best modest improvements with expensive interventions that are not sustainable outside of the research setting. The need for affordable, sustainable treatments is not confined to HIV care; it has been estimated that adherence to medications for chronic diseases averages about 50% in the developed world, while 80% or better is needed to obtain most of the benefits - and 95% or better for ART. If successful, this approach can be used to improve the management and outcomes of many chronic health conditions, such as heart disease, asthma, diabetes and cancer. This system, referred to as USE-MI (Unobtrusive Sensing of Medication Intake), builds upon the broad social acceptance of "wearable" electronic devices used by millions of Americans to establish individual health goals and provide real-time monitoring and feedback of individual performance. In this project, patients undergoing ART and PrEP will utilize the USE-MI platform to: Provide unobtrusive reminders to patients by using the combination of smartphone and wearable device alarms, the system will flexibly provide discreet medication reminders without drawing undo attention to the individual or the action. Unobtrusively detect medication intake - motion sensing and near-field communication technology will allow real-time confirmation of taking medications and provision of alerts in the event of medication error(s) due to the wrong drug or the wrong timing, without requiring any special action by the patient. Provide patient feedback - the smartphone application will give patients direct reports of their medication adherence and enable delivery of targeted behavioral interventions to enhance adherence. Improve communication between patients and care teams by offering clinicians and patients shared access to a medication scheduling application utilizing a mobile device platform to unambiguously establish medication regimen and to make immediate changes to the regimen as needed. Enhance and monitor medication adherence - a simple "dashboard" function will be made available to the patient and the treatment team to enable discussions about adherence, side-effect minimization strategies, and improvements and adjustments to medication regimens based on accurate data.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$158,275 )
2023	2018	SWEDISH HEALTH SERVICES	747 BROADWAY	SEATTLE	WA	98122	KING	USA	Mental Health Research Grants	000	4	7/19/2023	NON-COMPETING CONTINUATION	-$158,275
														Subtotal = -$158,275

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2018	SWEDISH HEALTH SERVICES	747 BROADWAY	SEATTLE	WA	98122	KING	USA	Mental Health Research Grants	000	4	6/24/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	SWEDISH HEALTH SERVICES	747 BROADWAY	SEATTLE	WA	98122	KING	USA	Mental Health Research Grants	000	4	6/30/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $749,942 )
2018	2018	SWEDISH HEALTH SERVICES	747 BROADWAY	SEATTLE	WA	98122	KING	USA	Mental Health Research Grants	000	4	6/15/2018	NON-COMPETING CONTINUATION	$749,942
														Subtotal = $749,942

Issue Date FY: 2017 ( Subtotal = $732,011 )
2017	2017	SWEDISH HEALTH SERVICES	747 BROADWAY	SEATTLE	WA	98122	KING	USA	Mental Health Research Grants	000	3	6/28/2017	NON-COMPETING CONTINUATION	$732,011
														Subtotal = $732,011

Issue Date FY: 2016 ( Subtotal = $763,207 )
2016	2016	SWEDISH MEDICAL CENTER	747 BROADWAY	SEATTLE	WA	98122	KING	USA	Mental Health Research Grants	000	2	6/29/2016	NON-COMPETING CONTINUATION	$763,207
														Subtotal = $763,207

Issue Date FY: 2015 ( Subtotal = $668,709 )
2015	2015	SWEDISH MEDICAL CENTER	747 BROADWAY	SEATTLE	WA	98122	KING	USA	Mental Health Research Grants	001	1	9/28/2015	NEW	-$242
2015	2015	SWEDISH MEDICAL CENTER	747 BROADWAY	SEATTLE	WA	98122	KING	USA	Mental Health Research Grants	000	1	9/25/2015	NEW	$668,951
														Subtotal = $668,709

Grand Total All Awards = $2,755,594

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Unobtrusive Sensing of Medication Intake ("USE-MI")

Award Number: R01MH109319

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/25/2015

PERIOD OF PERFORMANCE END DATE: 06/30/2022

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