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Hippocampal modulation of subcortical circuits in the control of emotional behavior

Award Number: R01MH108623
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2016
PERIOD OF PERFORMANCE END DATE: 01/31/2026

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Hippocampal modulation of subcortical circuits in the control of emotional behavior - Project Summary Almost a third of adult Americans suffer from an anxiety disorder, carrying an enormous personal, societal and financial burden. Anxiety disorders are complex circuit-based conditions, resulting from dysfunction in a number of distributed regions, connections, and cell types that generate normal adaptive behavior. Thus, a deeper understanding of how these neural circuits become disrupted to generate maladaptive behavior is crucial if we hope to generate new treatments. In recent years, we have shown that the ventral hippocampus (vHPC) is an central node in the extended circuit that generates adaptive avoidance behavior. However, the input- output organization of the ventral hippocampus in the control of anxiety-related behavior remains poorly understood. Here, we will use functional imaging of large populations of anatomically defined vHPC neurons, optical manipulation of these neurons, and high resolution behavioral analyses to expand our understanding of how the extended ventral hippocampal network controls behavior. We will first determine the encoding properties of vHPC output neurons to subcortical areas known to drive avoidance and anxiety-like behavior. Then, we will adopt new unsupervised behavioral classification tools for understanding anxiety-related behavior in mice to determine how vHPC projection neurons orchestrate distinct behavioral states. Finally, we will determine how distinct inputs to the differentially modulate avoidance behavior and shape anxiety-related representations in vHPC. This will provide the most detailed functional map of the extended hippocampal circuit that controls avoidance behavior, and provide novel targets for generation of therapeutics for the treatment of anxiety disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $640,280 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Mental Health Research Grants	001	10	9/23/2025	NON-COMPETING CONTINUATION	$96,042
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Mental Health Research Grants	000	10	3/12/2025	NON-COMPETING CONTINUATION	$544,238
														Subtotal = $640,280

Issue Date FY: 2024 ( Subtotal = $647,547 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Mental Health Research Grants	000	9	1/17/2024	NON-COMPETING CONTINUATION	$582,793
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Mental Health Research Grants	001	9	8/14/2024	NON-COMPETING CONTINUATION	$64,754
														Subtotal = $647,547

Issue Date FY: 2023 ( Subtotal = $579,160 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Mental Health Research Grants	000	8	1/18/2023	NON-COMPETING CONTINUATION	$579,160
														Subtotal = $579,160

Issue Date FY: 2022 ( Subtotal = $634,348 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Mental Health Research Grants	001	7	1/21/2022	NON-COMPETING CONTINUATION	$570,914
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Mental Health Research Grants	002	7	5/12/2022	NON-COMPETING CONTINUATION	$63,434
2022	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Mental Health Research Grants	000	5	10/18/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $634,348

Issue Date FY: 2021 ( Subtotal = $660,467 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Mental Health Research Grants	000	6	4/5/2021	COMPETING CONTINUATION	$594,421
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Mental Health Research Grants	001	6	5/7/2021	COMPETING CONTINUATION	$66,046
														Subtotal = $660,467

Issue Date FY: 2020 ( Subtotal = $396,250 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Mental Health Research Grants	000	5	2/26/2020	NON-COMPETING CONTINUATION	$396,250
														Subtotal = $396,250

Issue Date FY: 2019 ( Subtotal = $396,250 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Mental Health Research Grants	000	4	2/21/2019	NON-COMPETING CONTINUATION	$396,250
														Subtotal = $396,250

Issue Date FY: 2018 ( Subtotal = $396,250 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Mental Health Research Grants	001	3	6/17/2018	NON-COMPETING CONTINUATION	$39,625
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Mental Health Research Grants	000	3	2/21/2018	NON-COMPETING CONTINUATION	$356,625
														Subtotal = $396,250

Issue Date FY: 2017 ( Subtotal = $396,250 )
2017	2017	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Mental Health Research Grants	000	2	2/15/2017	NON-COMPETING CONTINUATION	$356,625
2017	2017	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Mental Health Research Grants	001	2	7/25/2017	NON-COMPETING CONTINUATION	$39,625
														Subtotal = $396,250

Issue Date FY: 2016 ( Subtotal = $407,625 )
2016	2016	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Mental Health Research Grants	000	1	3/18/2016	NEW	$407,625
														Subtotal = $407,625

Grand Total All Awards = $5,154,427

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Hippocampal modulation of subcortical circuits in the control of emotional behavior

Award Number: R01MH108623

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2016

PERIOD OF PERFORMANCE END DATE: 01/31/2026

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