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1/3 Cognitive Behavioral Social Skills Training for Youth at Risk of Psychosis

Award Number: R01MH105178
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/26/2014
PERIOD OF PERFORMANCE END DATE: 07/31/2020

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1/3 Cognitive Behavioral Social Skills Training for Youth at Risk of Psychosis - DESCRIPTION (provided by applicant): Schizophrenia and other psychotic disorders are serious and debilitating mental illnesses that incur substantial suffering for patients and major challenges to our health care and legal systems. The prodrome is the period prior to onset of psychosis when functional decline and clinical symptoms gradually emerge. The presence of a clinical high-risk (CHR) syndrome in young adults is associated with heightened risk (25-35%) for the later development of psychosis, and for those who do not necessarily go on to develop a psychotic illness, research has suggested that the majority continue to have fluctuating subthreshold symptoms and poor social and role functioning. There are no specific treatments to help with these functional difficulties. However, recent findings suggest that in people with schizophrenia, Cognitive Behavioral and Social Skills Training (CBSST) leads to significantly greater increase in the frequency of social functioning activities compared to treatment as usual or goal- focused supportive therapy, and preliminary data suggest CBSST is a feasible treatment for CHR. This application is a competitive application for a three-site, longitudinal study aimed at testing the effectiveness and feasibility as well as mediators and mechanisms of action of a manualized CBSST intervention that will target functional difficulties associated with clinical risk states for psychosis. The goals are 1) to examine whether CBSST compared to a placebo intervention (psychoeducation) matched for group involvement and therapist time improves functioning in youth at CHR and 2) to determine whether reduction in defeatist beliefs and improvement in social competence mediate change in psychosocial functioning in CHR youth in the CBSST. In this single-blind randomized 2-arm trial participants will be randomized to one of two treatments: CBSST, an 18-week group comprised of three modules; 1) Cognitive Skills; 2) Social Skills; and 3) Problem Solving, or a psychoeducation support group that does not teach active cognitive behavioral therapy or social skills training. Over a five-year period, te multi-site collaboration will follow large CHR sample that will undergo comprehensive assessments of psychosocial and behavioral changes, to examine changes in social and role functioning, as well as symptom changes from baseline to the end of treatment, and to 6 month follow-up. This approach will demonstrate the feasibility of a treatment for which it is easy to train therapists and which can readily be disseminated to regular clinical community practice. In addition, it will provide insights into likely approaches to halting or mitigating the pathological process and advance our understanding of risk prediction; both critical steps in prevention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = -$3,638 )
2021	2018	GOVERNORS OF THE UNIVERSITY OF CALGARY, THE	2500 UNIVERSITY DR NW	CALGARY	AB			CAN	Mental Health Research Grants	000	5	12/4/2020	NON-COMPETING CONTINUATION	-$3,638
														Subtotal = -$3,638

Issue Date FY: 2018 ( Subtotal = $260,214 )
2018	2018	GOVERNORS OF THE UNIVERSITY OF CALGARY, THE	2500 UNIVERSITY DR NW	CALGARY	AB	T2N 1N4		CAN	Mental Health Research Grants	000	5	7/11/2018	NON-COMPETING CONTINUATION	$260,214
														Subtotal = $260,214

Issue Date FY: 2017 ( Subtotal = $273,707 )
2017	2017	GOVERNORS OF THE UNIVERSITY OF CALGARY, THE	2500 UNIVERSITY DR NW	CALGARY	AB	T2N 1N4		CAN	Mental Health Research Grants	000	4	8/3/2017	NON-COMPETING CONTINUATION	$273,707
														Subtotal = $273,707

Issue Date FY: 2016 ( Subtotal = $285,992 )
2016	2016	UNIVERSITY OF CALGARY	**	CALGARY, ALBERTA				CAN	Mental Health Research Grants	000	3	6/25/2016	NON-COMPETING CONTINUATION	$285,992
														Subtotal = $285,992

Issue Date FY: 2015 ( Subtotal = $285,992 )
2015	2015	UNIVERSITY OF CALGARY	**	CALGARY, ALBERTA				CAN	Mental Health Research Grants	000	2	7/10/2015	NON-COMPETING CONTINUATION	$285,992
														Subtotal = $285,992

Issue Date FY: 2014 ( Subtotal = $281,969 )
2014	2014	UNIVERSITY OF CALGARY	**	CALGARY, ALBERTA				CAN	Mental Health Research Grants	000	1	9/26/2014	NEW	$281,969
														Subtotal = $281,969

Grand Total All Awards = $1,384,236

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1/3 Cognitive Behavioral Social Skills Training for Youth at Risk of Psychosis

Award Number: R01MH105178

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/26/2014

PERIOD OF PERFORMANCE END DATE: 07/31/2020

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