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The Autistic Brain Over 45: The Anatomic, Functional, and Cognitive Phenotype

Award Number: R01MH103494
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/08/2015
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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The Autistic Brain Over 45: The Anatomic, Functional, and Cognitive Phenotype - Project Summary Extremely little is known about neural and cognitive changes or long-term prognosis for adults with autism spectrum disorders (ASD) older than 50 years of age, although in the US alone hundreds of thousands of people with ASD will reach this age group in the coming decades. Cross-sectional findings suggest that new cognitive, sensorimotor, and mental health problems emerge and that accelerated brain tissue loss occurs. Functional and structural brain connectivity is also affected, as shown with resting state functional MRI and diffusion MRI. This project aims to characterize mid- to late-life trajectories of brain anatomy and function in ASD, as well as cognitive and behavioral change, and identify risk factors that predict poor outcomes including suspected effects of declining GABA concentrations and excitatory:inhibitory imbalance in aging. The proposed renewal will leverage an existing cohort (Cohort 1) of 40-70 year olds with ASD and matched typical comparison (TC) participants. In addition, a new cohort (Cohort 2) of 50 individuals with ASD and 70 TC participants age 40-70 will be recruited. Both cohorts will be followed longitudinally, with data collection every 3.5-5 years. Extensive data will be acquired at each time-point, including multimodal MRI scans, measures of GABA concentration from MR spectroscopy, diagnostic, cognitive, and behavioral assessments, as well as medical and personal history information. The project will pursue 3 specific aims. Aims 1 will identify alterations (and altered rates of change) in brain anatomy, function, and connectivity and relate these to behavioral changes in 3 suspected risk domains of Motor, Executive, and Affective function. Aim 2 will test for group differences and effects of age in GABA concentrations and in network integration and segregation. Aim 3 will identify behavioral and neural risk factors of adverse (or positive) outcomes (e.g. on scales of maladaptive behavior, loss of daily living skills) using machine learning, and identify ASD subgroups based on GABA levels, differential rates of change, or differential domain-specificity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $634,555 )
2025	2025	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR	SAN DIEGO	CA	92182	SAN DIEGO	USA	Mental Health Research Grants	000	10	4/25/2025	NON-COMPETING CONTINUATION	$634,555
														Subtotal = $634,555

Issue Date FY: 2024 ( Subtotal = $752,343 )
2024	2024	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR	SAN DIEGO	CA	92182	SAN DIEGO	USA	Mental Health Research Grants	000	9	4/23/2024	NON-COMPETING CONTINUATION	$752,343
														Subtotal = $752,343

Issue Date FY: 2023 ( Subtotal = $674,660 )
2023	2023	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Mental Health Research Grants	000	8	4/25/2023	NON-COMPETING CONTINUATION	$674,660
														Subtotal = $674,660

Issue Date FY: 2022 ( Subtotal = $701,187 )
2022	2022	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Mental Health Research Grants	002	7	5/11/2022	NON-COMPETING CONTINUATION	$701,187
2022	2021	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Mental Health Research Grants	001	6	12/10/2021	COMPETING CONTINUATION	$127,280
2022	2020	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Mental Health Research Grants	000	5	12/7/2021	NON-COMPETING CONTINUATION	-$127,280
														Subtotal = $701,187

Issue Date FY: 2021 ( Subtotal = $743,961 )
2021	2021	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Mental Health Research Grants	002	6	6/14/2021	COMPETING CONTINUATION	$743,961
2021	2020	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Mental Health Research Grants	000	5	1/27/2021	NON-COMPETING CONTINUATION	$0
2021	2020	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Mental Health Research Grants	001	5	6/14/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $743,961

Issue Date FY: 2020 ( Subtotal = $669,239 )
2020	2020	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Mental Health Research Grants	000	5	2/6/2020	NON-COMPETING CONTINUATION	$669,239
														Subtotal = $669,239

Issue Date FY: 2019 ( Subtotal = $669,916 )
2019	2019	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Mental Health Research Grants	000	4	1/29/2019	NON-COMPETING CONTINUATION	$669,916
														Subtotal = $669,916

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2017	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Mental Health Research Grants	000	3	3/8/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $691,010 )
2017	2017	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Mental Health Research Grants	001	3	6/21/2017	NON-COMPETING CONTINUATION	$69,103
2017	2017	SAN DIEGO STATE UNIVERSITY FOUNDATION	5250 CAMPANILE DR MC1947	SAN DIEGO	CA	92182	SAN DIEGO	USA	Mental Health Research Grants	000	3	1/27/2017	NON-COMPETING CONTINUATION	$621,907
														Subtotal = $691,010

Issue Date FY: 2016 ( Subtotal = $703,652 )
2016	2016	SAN DIEGO STATE UNIVERSITY, FOUNDATION	SAN DIEGO STATE UNIVERSITY	SAN DIEGO	CA	92182	SAN DIEGO	USA	Mental Health Research Grants	000	2	1/28/2016	NON-COMPETING CONTINUATION	$703,652
														Subtotal = $703,652

Issue Date FY: 2015 ( Subtotal = $771,520 )
2015	2015	SAN DIEGO STATE UNIVERSITY, FOUNDATION	SAN DIEGO STATE UNIVERSITY	SAN DIEGO	CA	92182	SAN DIEGO	USA	Mental Health Research Grants	000	1	5/8/2015	NEW	$771,520
														Subtotal = $771,520

Grand Total All Awards = $7,012,043

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The Autistic Brain Over 45: The Anatomic, Functional, and Cognitive Phenotype

Award Number: R01MH103494

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/08/2015

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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