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Timing, reward processing and choice

Award Number: R01MH085739
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/20/2010
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Timing, reward processing and choice - PROJECT SUMMARY Impulsive choices involve trade-offs between amount and delay by delivering smaller-sooner (SS) versus larger-later (LL) rewards. Impulsive choices occur when individuals frequently choose the SS when it is suboptimal to do so. Impulsive choices have been identified as a trans-disease process due to their association with a wide range of diseases and disorders including substance abuse, gambling, obesity, and attention-deficit/hyperactivity disorder. Impulsive choice can be both a pre-cursor to and product of maladaptive behaviors. The overarching goal of our research program is to identify the underlying mechanisms of impulsive choices and target those mechanisms using interventions to promote self-control. Time discrimination deficits and delay intolerance predicted stable individual differences in impulsive choice in the rat pre-clinical model. Poor timing and delay intolerance are purported endophenotypes in attention-deficit/hyperactivity disorder, providing important links with the rodent pre-clinical model. Time-based interventions have successfully moderated impulsive choices and improved time discrimination in rodents. Time-based interventions were most successful in promoting self-control in the most impulsive individuals. Most importantly, interventions that involved active waiting and that required time discrimination were most effective, suggesting a causal role for timing processes in the time-based interventions. Based on the previous results, the timing dysfunction model (TDM) proposes that impulsive choices arise from distorted timing processes, which may result in imprecise or inaccurate timing. Dysfunctional timing processes can lead to impulsive choices. Thus, the TDM proposes that timing processes are a primary candidate for therapeutic interventions. In addition, different neurobiological mechanisms may be responsible for the different contributions of specific timing processes to impulsive choices. Aim 1 will demonstrate distinct roles for specific timing processes in promoting self-control. This aim will confirm the TDM and pinpoint the mechanisms of time-based intervention effects on impulsive choices for future neuroscientific and translational research. Aim 2 will assess effects of the interventions on structural connectivity in cortico-striatal pathways, which are prime candidates for the time-based intervention effects on timing and impulsive choices. This aim will use diffusion tensor imaging (DTI) to measure structural connectivity. Aim 3 will use Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) to depress activity in neurobiological pathways that are likely candidates for the time-based intervention effects. The three aims will identify specific cognitive and neural mechanisms of time-based interventions. This research is significant due the critical need for effective interventions to moderate impulsive choices. As a trans-disease process, impulsive choice has broad relevance for human health and is of significant relevance to the NIMH mission.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $494,239 )
2025	2025	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Mental Health Research Grants	005	14	5/28/2025	NON-COMPETING CONTINUATION	$416,176
2025	2025	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Mental Health Research Grants	004	13	4/29/2025	SUPPLEMENT FOR EXPANSION	$0
2025	2025	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Mental Health Research Grants	000	13	12/3/2024	SUPPLEMENT FOR EXPANSION	$78,063
2025	2024	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Mental Health Research Grants	003	13	4/28/2025	NON-COMPETING CONTINUATION	$0
2025	2023	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Mental Health Research Grants	002	12	2/12/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$71,099
2025	2022	KANSAS STATE UNIVERSITY	1601 VATTIER STREET	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	001	11	2/12/2025	NON-COMPETING CONTINUATION	-$71,099
														Subtotal = $494,239

Issue Date FY: 2024 ( Subtotal = $416,176 )
2024	2024	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Mental Health Research Grants	000	13	6/21/2024	NON-COMPETING CONTINUATION	$416,176
														Subtotal = $416,176

Issue Date FY: 2023 ( Subtotal = $416,176 )
2023	2023	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Mental Health Research Grants	002	12	9/13/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$416,176
2023	2022	KANSAS STATE UNIVERSITY	1601 VATTIER STREET	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	001	11	9/12/2023	NON-COMPETING CONTINUATION	$0
2023	2022	KANSAS STATE UNIVERSITY	1601 VATTIER STREET	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	000	11	5/8/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $416,176

Issue Date FY: 2022 ( Subtotal = $369,684 )
2022	2022	KANSAS STATE UNIVERSITY	2 FAIRCHILD HALL	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	001	11	6/28/2022	NON-COMPETING CONTINUATION	$369,684
2022	2019	KANSAS STATE UNIVERSITY	1601 VATTIER STREET	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	000	9	4/18/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $369,684

Issue Date FY: 2021 ( Subtotal = $370,221 )
2021	2021	KANSAS STATE UNIVERSITY	2 FAIRCHILD HALL	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	003	10	8/25/2021	COMPETING CONTINUATION	$370,221
2021	2019	KANSAS STATE UNIVERSITY	2 FAIRCHILD HALL	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	000	9	2/26/2021	NON-COMPETING CONTINUATION	$0
2021	2019	KANSAS STATE UNIVERSITY	2 FAIRCHILD HALL	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	002	9	8/17/2021	NON-COMPETING CONTINUATION	$0
2021	2019	KANSAS STATE UNIVERSITY	2 FAIRCHILD HALL	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	001	9	4/7/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $370,221

Issue Date FY: 2019 ( Subtotal = $337,500 )
2019	2019	KANSAS STATE UNIVERSITY	2 FAIRCHILD HALL	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	000	9	2/20/2019	NON-COMPETING CONTINUATION	$337,500
														Subtotal = $337,500

Issue Date FY: 2018 ( Subtotal = $337,500 )
2018	2018	KANSAS STATE UNIVERSITY	2 FAIRCHILD HALL	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	000	8	2/21/2018	NON-COMPETING CONTINUATION	$303,750
2018	2018	KANSAS STATE UNIVERSITY	2 FAIRCHILD HALL	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	001	8	6/15/2018	NON-COMPETING CONTINUATION	$33,750
														Subtotal = $337,500

Issue Date FY: 2017 ( Subtotal = $337,500 )
2017	2017	KANSAS STATE UNIVERSITY	2 FAIRCHILD HALL	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	001	7	7/18/2017	NON-COMPETING CONTINUATION	$33,750
2017	2017	KANSAS STATE UNIVERSITY	2 FAIRCHILD HALL	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	000	7	2/23/2017	NON-COMPETING CONTINUATION	$303,750
														Subtotal = $337,500

Issue Date FY: 2016 ( Subtotal = $337,500 )
2016	2016	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	000	6	5/6/2016	COMPETING CONTINUATION	$337,500
														Subtotal = $337,500

Issue Date FY: 2014 ( Subtotal = $256,410 )
2014	2014	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	000	5	2/24/2014	NON-COMPETING CONTINUATION	$256,410
														Subtotal = $256,410

Issue Date FY: 2013 ( Subtotal = $246,154 )
2013	2013	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	000	4	1/18/2013	NON-COMPETING CONTINUATION	$230,769
2013	2013	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	001	4	6/27/2013	NON-COMPETING CONTINUATION	$15,385
														Subtotal = $246,154

Issue Date FY: 2012 ( Subtotal = $256,410 )
2012	2012	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	000	3	2/1/2012	NON-COMPETING CONTINUATION	$256,410
														Subtotal = $256,410

Issue Date FY: 2011 ( Subtotal = $256,410 )
2011	2011	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	000	2	3/26/2011	NON-COMPETING CONTINUATION	$233,100
2011	2011	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	001	2	6/28/2011	NON-COMPETING CONTINUATION	$23,310
														Subtotal = $256,410

Issue Date FY: 2010 ( Subtotal = $244,930 )
2010	2010	KANSAS STATE UNIVERSITY, AGRICULTURE & APPLIED SCIENCE	ANDERSON HALL ROOM 206	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	000	1	5/18/2010	NEW	$244,930
														Subtotal = $244,930

Grand Total All Awards = $4,676,810

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Timing, reward processing and choice

Award Number: R01MH085739

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/20/2010

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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