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GENETIC VARIATION IN MICRORNA TARGETS IN CANDIDATE GENES FOR MENTAL DISORDERS

Award Number: R01MH080427
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/20/2007
PERIOD OF PERFORMANCE END DATE: 05/31/2010

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GENETIC VARIATION IN MICRORNA TARGETS IN CANDIDATE GENES FOR MENTAL DISORDERS - DESCRIPTION (provided by applicant): Over the past twenty years, the Genetic Epidemiology Unit at the Queensland Institute of Medical Research, under the direction of Dr Nick Martin, has conducted large scale genetic epidemiologic studies on a wide range of psychiatric phenotypes. These studies have exploited the Australian Twin Registry (established by N. Martin in 1978 with the first 15,000 pairs) and have come out of a series of NIAAA, NIDA and NIMH funded collaborative programs with US colleagues, notably Drs A. Heath and R. Todd at Washington University, St Louis. These include projects on the genetics of anxiety & depression (3000 subjects), alcohol dependence (5000), nicotine dependence (5000), opioid dependence (3000 - 60% complete) and ADHD (4000 -just starting). Often, as in the anxiety & depression collection for the current proposal, blood for DNA is obtained from sibships selected from a much larger set of phenotyped individuals, using an EDAC (extreme-discordant and concordant) design. In addition our Genome laboratory hosts and supervises the genotyping requirements of the largest schizophrenia genetics project in Australia directed by Dr Bryan Mowry. The common strategy we have applied is to perform genome-wide genetic linkage studies followed by fine-mapping in appropriate regions. In the present proposal we take a more direct approach by targeting known genetic variations in a set of 605 candidate genes for psychiatric disease in which the variants potentially alter a target site for microRNAs, a critical set of genes involved in control of gene expression and development. Thus much of our work is directed towards understanding fundamental causes of some of the most debilitating disorders in human health and which represent the major drain on public health throughout the world. These behavioral disorders represent some of the most recalcitrant public health issues which remain resistant to treatment and amelioration. Even where there may be effective therapies the mechanism of action is usually unknown. Our genetic strategies focus on identifying the inherited genetic c


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $209,632 )
2009	2009	QUEENSLAND INSTITUTE OF MEDICAL RESEARCH	300 Herston Road HERSTON	BRISBANE				AUS	Mental Health Research Grants	000	3	9/11/2009	NON-COMPETING CONTINUATION	$209,632
														Subtotal = $209,632

Issue Date FY: 2008 ( Subtotal = $228,690 )
2008	2008	QUEENSLAND INSTITUTE OF MEDICAL RESEARCH	BRAMSTON TERRACE HERSTON	BRISBANE				AUS	Mental Health Research Grants	000	2	5/28/2008	NON-COMPETING CONTINUATION	$228,690
														Subtotal = $228,690

Issue Date FY: 2007 ( Subtotal = $253,314 )
2007	2007	QUEENSLAND INSTITUTE OF MEDICAL RESEARCH	BRAMSTON TERRACE HERSTON	BRISBANE				AUS	Mental Health Research Grants	000	1	6/19/2007	NEW	$253,314
														Subtotal = $253,314

Grand Total All Awards = $691,636

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GENETIC VARIATION IN MICRORNA TARGETS IN CANDIDATE GENES FOR MENTAL DISORDERS

Award Number: R01MH080427

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/20/2007

PERIOD OF PERFORMANCE END DATE: 05/31/2010

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