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FUNCTIONAL SIGNIFICANCE OF NETWORK DYNAMICS IN HIPPOCAMPAL CIRCUITS

Award Number: R01MH079971
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2007
PERIOD OF PERFORMANCE END DATE: 08/31/2012

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FUNCTIONAL SIGNIFICANCE OF NETWORK DYNAMICS IN HIPPOCAMPAL CIRCUITS - DESCRIPTION (provided by applicant): The hippocampus is an essential structure for remembering personal events that have occurred in unique spatial and temporal contexts (episodic memory). The long-term objective of this project is to understand how detailed hippocampal circuits (i.e., subfields) and associated cortical areas process event-related information and to establish a causal relationship between these neural processes and mnemonic behavior. Advanced recording techniques and sophisticated analytical methods currently allow monitoring of the firing patterns of a large number of neurons simultaneously from multiple brain regions in freely behaving animals. With respect to episodic memory, however, the functional significance of the knowledge gained by using these techniques remains unclear, because the neural activity is rarely recorded when the animals are engaged in an episodic-like memory task. This project will fill this critical gap and elucidate how different networks of neurons in the hippocampus contribute to the animal's behavior when context-specific events need to be encoded and retrieved. Computational models predict that the dentate gyrus and CAS subfields of the hippocampus are essential when independent representations of different contexts need to be formed (pattern separation) and also when original representations of contexts need to be retrieved in the face of incomplete/ambiguous contexts (pattern completion). This proposal will test these critical predictions from the computational models by adopting an innovative investigative strategy. Specifically, the animals will be required to produce discrete behavioral responses in association with different contextual environments. Furthermore, this proposal seeks to identify the relationship between these context-dependent, behavioral responses and the ensemble neuronal activity recorded from multiple hippocampal subfields simultaneously. The outcomes from the current project will thus advance our knowledge of how episodic memory components are processed in detailed hippocampal circuits by linking the predictions from computational theories, physiological properties of neural networks, and mnemonic behavior. Clinically, damage within the hippocampus and associated areas (e.g., in Alzheimer's disease and schizophrenia) results in a devastating amnesic syndrome. The outcomes from this proposal will thus contribute to creating improved diagnosis and treatment of the hippocampal-dependent amnesia.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = $0 )
2013	2011	SEOUL NATIONAL UNIVERSITY	M405 BUILDING 16	SEOUL				KOR	Mental Health Research Grants	000	6	6/6/2013	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2011 ( Subtotal = $216,513 )
2011	2011	SEOUL NATIONAL UNIVERSITY	M424 Bldg. 16,Seoul National Univer	Seoul				KOR	Mental Health Research Grants	000	6	7/20/2011	NON-COMPETING CONTINUATION	$216,513
														Subtotal = $216,513

Issue Date FY: 2010 ( Subtotal = $218,700 )
2010	2010	SEOUL NATIONAL UNIVERSITY	M424 Bldg. 16,Seoul National Univer	Seoul				KOR	Mental Health Research Grants	005	5	7/19/2010	NON-COMPETING CONTINUATION	$218,700
2010	2009	SEOUL NATIONAL UNIVERSITY	M405 BUILDING 16	SEOUL				KOR	Mental Health Research Grants	004	4	2/19/2010	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2010	2009	SEOUL NATIONAL UNIVERSITY	M424 Bldg. 16,Seoul National Univer	Seoul				KOR	Mental Health Research Grants	001	4	11/13/2009	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$231,394
2010	2009	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Mental Health Research Grants	003	3	12/3/2009	NON-COMPETING CONTINUATION	$70,085
2010	2009	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Mental Health Research Grants	000	3	11/13/2009	NON-COMPETING CONTINUATION	-$231,394
2010	2009	SEOUL NATIONAL UNIVERSITY	M424 Bldg. 16,Seoul National Univer	Seoul				KOR	Mental Health Research Grants	002	4	12/3/2009	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$70,085
														Subtotal = $218,700

Issue Date FY: 2009 ( Subtotal = $298,688 )
2009	2009	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Mental Health Research Grants	000	3	4/13/2009	NON-COMPETING CONTINUATION	$298,688
														Subtotal = $298,688

Issue Date FY: 2008 ( Subtotal = $298,688 )
2008	2008	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Mental Health Research Grants	000	2	3/19/2008	NON-COMPETING CONTINUATION	$298,688
														Subtotal = $298,688

Issue Date FY: 2007 ( Subtotal = $298,688 )
2007	2007	UNIVERSITY OF IOWA	2 GILMORE HALL	IOWA CITY	IA	52242	JOHNSON	USA	Mental Health Research Grants	000	1	3/30/2007	NEW	$298,688
														Subtotal = $298,688

Grand Total All Awards = $1,331,277

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FUNCTIONAL SIGNIFICANCE OF NETWORK DYNAMICS IN HIPPOCAMPAL CIRCUITS

Award Number: R01MH079971

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2007

PERIOD OF PERFORMANCE END DATE: 08/31/2012

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