Thursday, May 19, 2022
5/19/2022
This is the competing renewal of the R01 (MH074457-14) which sustains the BrainMap Project (www.brainmap.org). BrainMap is a neuroimaging research resource facilitating cognitive neuroscience and disease-biomarker discovery via coordinate-based meta-analysis (CBMA). BrainMap provides its end-user community with: curated 3-D coordinate data and experimental metadata from peer-reviewed publications; extensively validated computational tools for CBMA; CBMA-derived tools for data interpretation (e.g., functional property and disease loadings by location) and data analysis (e.g., via CBMA-derived disease models); instructional materials and on-site and on-line venues for learning CBMA methods; and, on-going end-user support. At present, BrainMap.org hosts two coordinate-based databases: task-activation (TA DB) and voxel- based morphometry (VBM DB). A voxel-based physiology database (VBP DB) is in the planning and piloting phase. BrainMap maintains an integrated pipeline of cross-platform (Java) tools for data coding (Scribe), filtered retrieval (Sleuth), activation-likelihood estimation (ALE) CBMA (GingerALE), data visualization (Mango), and data interpretation (CBMA-derived Mango plugins). Multiple network-modeling approaches have been successfully applied to BrainMap data – independent components analysis (ICA), author-topic modeling (ATM), graph-theory modeling (GTM), structural equation modeling (SEM), connectivity-based parcellation (CBP), and meta-analytic connectivity modeling (MACM) – but none are yet optimized and “pipelined” for general use. Utilization of BrainMap resources is substantial: our software, data and meta-data have been used in >1,000 peer-reviewed articles. Of these, > 500 were published in the current funding cycle (2015- 2020). Four aims are proposed, to maintain and extend this high-impact research resource. Aim 1. Voxel-based Physiology DataBase (VBP DB) with Analysis Exemplars. Aim 2. BrainMap Community Portal for Multivariate Modeling with Applications & Exemplars. Aim 3. Large-scale Parameter Estimations. Aim 4. BrainMap Pipeline Enhancements and Community Support.
HHS’ Tracking Accountability in Government Grants System (TAGGS) website provides access to detailed descriptions of grants, loans, aggregated direct payments and other types of financial assistance awarded by the HHS Operating Divisions (OPDIVs) and the Office of the Secretary Staff Divisions (STAFFDIVs).
