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ELECTRONIC ATLAS OF HUMAN FETAL BRAIN GENE EXPRESSION

Award Number: R01MH070370
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/11/2006
PERIOD OF PERFORMANCE END DATE: 04/30/2010

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ELECTRONIC ATLAS OF HUMAN FETAL BRAIN GENE EXPRESSION - DESCRIPTION (provided by applicant): We need to understand more about how the fetal brain develops for two main reasons. Firstly, abnormalities arising in early development are common and disorders of brain development affect many babies, often with severe consequences for their health and quality of life. Secondly, as humans we have unique or especially highly developed cognitive abilities (such as language), which cannot readily be studied in animal models. Contributing to these two goals is highly consistent with the mission statements of the NICHD and NIMH as they relate to understanding the development and function of the human brain. The informatics part of the project would contribute to the mission of the NIBIB to advance imaging and related technologies. Genes, and the protein products they make, drive development. If we are to understand how the brain is formed, we need to know when genes are switched on (expressed) in early development and in which cells of the brain. Identifying brain structures early in development is a difficult task, partly because structures may have very different sizes, shapes and even relative positions compared to their adult counterparts. The complex three-dimensional (3-D) structure, which also changes during development, adds to the difficulties. The general aim of our project, therefore, is to make an electronic atlas of the developing human brain (EADHB) which will capture expert knowledge to identify brain structures at different stages in digital, interactive 3-D models. These models will also be used for storing, sharing and analyzing the data on where and when genes are expressed in the developing brain. The gene expression data are best understood by relating them to the underlying anatomy and structure of the developing brain. The EADHB will, therefore, have two main components: 1) an electronic (2D and 3D) atlas of the anatomy and form of the developing brain- this will be useful as a teaching and learning tool to help in understanding human developmental brain anatomy, as well as providing a canvas onto which the information on where genes are expressed can be painted. 2) a gene expression database which will allow us to map in 2D and in 3D where genes are expressed in the brain and to relate this to the 2D and 3D anatomy of the brain. In our previous work we have been able to demonstrate on a small scale that we can accomplish this task. Because of the importance in relating the gene expression data to the anatomy of the brain, we are now proposing to collaborate with a world-leading expert in developmental brain anatomy, Professor Luis Puelles. In this new phase of our work we will make every effort to ensure that our brain atlas is readily accessible and linked to other electronic atlases for other species and other organ systems. The EADHB will provide a unique resource to neurobiologists, clinical scientists and educators.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $422,487 )
2009	2009	UNIVERSITY OF NEWCASTLE	6 KENSINGTON TERRACE	NEWCASTLE UPON TYNE				GBR	Mental Health Research Grants	002	4	4/29/2009	NON-COMPETING CONTINUATION	$422,487
2009	2007	UNIVERSITY OF NEWCASTLE	6 KENSINGTON TERRACE	NEWCASTLE UPON TYNE		00000			Mental Health Research Grants	001	2	12/24/2008	NON-COMPETING CONTINUATION	$0
2009	2006	UNIVERSITY OF NEWCASTLE	6 KENSINGTON TERRACE	NEWCASTLE UPON TYNE		00000			Mental Health Research Grants	000	1	12/24/2008	NEW	$0
														Subtotal = $422,487

Issue Date FY: 2007 ( Subtotal = $410,130 )
2007	2007	UNIVERSITY OF NEWCASTLE	6 KENSINGTON TERRACE	NEWCASTLE UPON TYNE		00000			Mental Health Research Grants	000	2	5/1/2007	NON-COMPETING CONTINUATION	$410,130
														Subtotal = $410,130

Issue Date FY: 2006 ( Subtotal = $439,556 )
2006	2006	UNIVERSITY OF NEWCASTLE UPON TYNE	**	NEWCASTLE-ON-TYN		00000			Mental Health Research Grants	000	1	8/18/2006	NEW	$439,556
														Subtotal = $439,556

Grand Total All Awards = $1,272,173

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ELECTRONIC ATLAS OF HUMAN FETAL BRAIN GENE EXPRESSION

Award Number: R01MH070370

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/11/2006

PERIOD OF PERFORMANCE END DATE: 04/30/2010

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