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MENTAL HEALTH OUTCOMES FOLLOWING CHILDHOOD MALNUTRITION

Award Number: R01MH065877
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2004
PERIOD OF PERFORMANCE END DATE: 05/31/2011

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MENTAL HEALTH OUTCOMES FOLLOWING CHILDHOOD MALNUTRITION - DESCRIPTION (provided by applicant): Malnutrition affects 25% of the children world-wide. In a series of over 40 published papers, we have documented the long-term effects of early protein-calorie malnutrition (PEM) and kwashiorkor in 333 Barbadian children and matched comparison cases from the same socioeconomic backgrounds. Now 30 to 35 years of age, the index children were diagnosed with moderate to severe protein-energy or protein malnutrition during their first year of life after which no further episodes occurred. All previously malnourished children were nutritionally rehabilitated shortly after their illness and were followed by the National Nutrition Centre on a regular basis, until they reached 11 years of age. Birth and postnatal data were available for all children in the study, and they were studied comprehensively throughout their school years (ages five to 18). When compared with controls at 5 to 11 years of age, previously malnourished children demonstrated a striking fourfold increase (15% versus 60%) in the incidence of behaviors associated with attention deficit disorder. Attentional problems at earlier ages predicted poor performance on the Eleven-Plus Examination, the national common entrance exam for high school placement taken by all Barbadian school children at 11 years of age. Attention problems persisted in 50% of the index children up to 18 years of age. Other deficits in the previously malnourished children included reduced IQ scores, soft neurological signs, learning disabilities and impaired social skills. In contrast, physical growth was delayed but showed complete "catch-up" by 16 years of age. To determine whether environmental factors contributed to these findings, socioeconomic conditions and factors in the child's home environment were evaluated at all stages of development, including at the time that malnutrition occurred. Data analyses controlling for these ecological factors confirmed significant independent effects of childhood malnutrition in all cases. In the current study, we propose to extend our studies of this population to their adult years. We plan to evaluate behavioral, cognitive and mental health outcomes, because of deficits documented in earlier years and other long-term studies of prenatal malnutrition, notable the Dutch Famine study, which pointed to the importance of aberrant mental health outcomes in adulthood. Given the availability in Barbados of 98% of our original population and the existence of the comprehensive set of longitudinal data that document their physical and mental development from birth through 18 years of age, we believe a follow-up study of this population in their adult years will make a significant contribution to our understanding of the long-term consequences of postnatal malnutrition on behavioral and mental health outcomes. To our knowledge, there are no other published studies on the adult consequences of postnatal malnutrition in human populations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $1 )
2010	2010	JUDGE BAKER CHILDREN'S CENTER	3 BLACKFAN CIRCLE	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	002	6	8/27/2010	NON-COMPETING CONTINUATION	$1
2010	2007	JUDGE BAKER CHILDREN'S CENTER	3 BLACKFAN CIRCLE	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	001	5	8/27/2010	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2010	2007	JUDGE BAKER CHILDREN'S CENTER	3 BLACKFAN CIRCLE	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	003	5	9/3/2010	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2010	2007	JUDGE BAKER CHILDREN'S CENTER	3 BLACKFAN CIRCLE	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	000	5	8/12/2010	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $1

Issue Date FY: 2009 ( Subtotal = $0 )
2009	2007	JUDGE BAKER CHILDREN'S CENTER	3 BLACKFAN CIRCLE	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	002	5	6/2/2009	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$304,193
2009	2007	BOSTON UNIVERSITY	25 BUICK ST	BOSTON	MA	02215	SUFFOLK	USA	Mental Health Research Grants	001	4	6/2/2009	NON-COMPETING CONTINUATION	-$304,193
2009	2007	JUDGE BAKER CHILDREN'S CENTER	3 BLACKFAN CIRCLE	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	004	5	6/8/2009	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$304,193
2009	2007	JUDGE BAKER CHILDREN'S CENTER	3 BLACKFAN CIRCLE	BOSTON	MA	02115	SUFFOLK	USA	Mental Health Research Grants	003	5	6/5/2009	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$304,193
2009	2007	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Mental Health Research Grants	000	4	5/12/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2007 ( Subtotal = $388,500 )
2007	2007	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Mental Health Research Grants	000	4	2/28/2007	NON-COMPETING CONTINUATION	$388,500
														Subtotal = $388,500

Issue Date FY: 2006 ( Subtotal = $374,866 )
2006	2006	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Mental Health Research Grants	000	3	2/10/2006	NON-COMPETING CONTINUATION	$374,866
														Subtotal = $374,866

Issue Date FY: 2005 ( Subtotal = $372,710 )
2005	2005	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Mental Health Research Grants	000	2	4/4/2005	NON-COMPETING CONTINUATION	$372,710
														Subtotal = $372,710

Issue Date FY: 2004 ( Subtotal = $405,759 )
2004	2004	BOSTON UNIVERSITY	25 BUICK STREET	BOSTON	MA	02215	SUFFOLK	USA	Mental Health Research Grants	000	1	4/19/2004	NEW	$405,759
														Subtotal = $405,759

Grand Total All Awards = $1,541,836

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MENTAL HEALTH OUTCOMES FOLLOWING CHILDHOOD MALNUTRITION

Award Number: R01MH065877

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2004

PERIOD OF PERFORMANCE END DATE: 05/31/2011

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