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Event-related Neuroimaging of Human Memory Formation

Award Number: R01MH060941
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/15/2000
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Event-related Neuroimaging of Human Memory Formation - Project Summary The overarching goals of this project are to illuminate the nature and functions of episodic memory by examining how retrieval of episodic memories supports cognitive functions that extend beyond simple recall of past events, such as imagining future experiences, solving everyday problems, and making inferences about the links among related events. Recent evidence indicates that the same core brain network is involved in both remembering past experiences and imagining or simulating hypothetical future experiences. The proposed experiments will use novel cognitive tasks and neuroscience-based measures, including both functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS), to elucidate how specific regions within this core network support constructive uses of episodic retrieval that underly future thinking, problem solving, and associative inferences. The studies will also examine how some of these adaptive functions can also lead to errors in episodic remembering. One set of studies will use a novel fMRI pattern similarity approach to clarify how two key regions in the core brain network – the hippocampus and angular gyrus – reinstate episodic information from past experiences when people imagine various kinds of future experiences. TMS will provide converging evidence by targeting hippocampal activity, which should specifically impact episodic reinstatement. A second set of studies will use a similar combination of fMRI pattern similarity and TMS approaches to revealing, for the first time, how episodic information is reinstated when people try to address everyday personal problems, including problems that are personally worrisome. These studies will draw on novel behavioral paradigms that recruit episodic retrieval processes during personal problem solving. A third set of experiments will attempt to identify the neural mechanisms underlying memory errors that result from adaptive use of episodic retrieval processes that support the ability to make associative inferences about the relations among events by combining novel behavioral paradigms with fMRI pattern similarity analysis. Overall, these experiments should enhance understanding of mechanisms involved in episodic retrieval, simulation, and problem solving by helping to refine recently novel measures developed in recent research, and could also provide insights that are relevant to clinical conditions in which episodic retrieval and simulation deficits contribute to impairments in everyday cognitive function.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $422,500 )
2025	2025	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	000	24	8/18/2025	NON-COMPETING CONTINUATION	$422,500
														Subtotal = $422,500

Issue Date FY: 2024 ( Subtotal = $422,500 )
2024	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE STE 3	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	000	23	7/23/2024	NON-COMPETING CONTINUATION	$422,500
														Subtotal = $422,500

Issue Date FY: 2023 ( Subtotal = $422,500 )
2023	2023	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE 5TH FL	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	000	22	6/23/2023	NON-COMPETING CONTINUATION	$422,500
														Subtotal = $422,500

Issue Date FY: 2022 ( Subtotal = $422,500 )
2022	2022	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE 5TH FL	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	002	21	7/14/2022	NON-COMPETING CONTINUATION	$422,500
2022	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE 5TH FL	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	001	20	5/3/2022	COMPETING CONTINUATION	$61,571
2022	2019	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE 5TH FL	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	000	19	5/3/2022	NON-COMPETING CONTINUATION	-$61,571
														Subtotal = $422,500

Issue Date FY: 2021 ( Subtotal = $422,500 )
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE 5TH FL	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	002	20	8/12/2021	COMPETING CONTINUATION	$422,500
2021	2019	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE 5TH FL	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	001	19	8/5/2021	NON-COMPETING CONTINUATION	$0
2021	2019	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE 5TH FL	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	000	19	2/13/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $422,500

Issue Date FY: 2019 ( Subtotal = $422,500 )
2019	2019	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE 5TH FL	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	000	19	2/18/2019	NON-COMPETING CONTINUATION	$422,500
														Subtotal = $422,500

Issue Date FY: 2018 ( Subtotal = $422,500 )
2018	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE 5TH FL	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	000	18	3/5/2018	NON-COMPETING CONTINUATION	$380,250
2018	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE 5TH FL	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	001	18	7/3/2018	NON-COMPETING CONTINUATION	$42,250
														Subtotal = $422,500

Issue Date FY: 2017 ( Subtotal = $422,500 )
2017	2017	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE 5TH FL	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	001	17	7/17/2017	NON-COMPETING CONTINUATION	$42,250
2017	2017	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	1033 MASSACHUSETTS AVE 5TH FL	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	000	17	3/8/2017	NON-COMPETING CONTINUATION	$380,250
														Subtotal = $422,500

Issue Date FY: 2016 ( Subtotal = $422,500 )
2016	2016	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	000	16	2/29/2016	NON-COMPETING CONTINUATION	$422,500
														Subtotal = $422,500

Issue Date FY: 2015 ( Subtotal = $422,500 )
2015	2015	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	000	15	3/13/2015	COMPETING CONTINUATION	$422,500
														Subtotal = $422,500

Issue Date FY: 2014 ( Subtotal = $415,800 )
2014	2014	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	000	14	2/27/2014	NON-COMPETING CONTINUATION	$415,800
														Subtotal = $415,800

Issue Date FY: 2013 ( Subtotal = $399,168 )
2013	2013	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	001	13	6/27/2013	NON-COMPETING CONTINUATION	$24,948
2013	2013	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	000	13	1/16/2013	NON-COMPETING CONTINUATION	$374,220
														Subtotal = $399,168

Issue Date FY: 2012 ( Subtotal = $415,800 )
2012	2012	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	000	12	1/26/2012	NON-COMPETING CONTINUATION	$415,800
														Subtotal = $415,800

Issue Date FY: 2011 ( Subtotal = $415,800 )
2011	2011	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	001	11	6/8/2011	NON-COMPETING CONTINUATION	$37,800
2011	2011	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	000	11	2/2/2011	NON-COMPETING CONTINUATION	$378,000
														Subtotal = $415,800

Issue Date FY: 2010 ( Subtotal = $420,000 )
2010	2010	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	001	10	5/5/2010	COMPETING CONTINUATION	$420,000
2010	2009	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	000	9	5/3/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $420,000

Issue Date FY: 2009 ( Subtotal = $409,399 )
2009	2009	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	000	9	4/23/2009	NON-COMPETING CONTINUATION	$409,399
														Subtotal = $409,399

Issue Date FY: 2008 ( Subtotal = $395,551 )
2008	2008	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	000	8	3/10/2008	NON-COMPETING CONTINUATION	$395,551
														Subtotal = $395,551

Issue Date FY: 2007 ( Subtotal = $393,504 )
2007	2007	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	000	7	4/5/2007	NON-COMPETING CONTINUATION	$393,504
														Subtotal = $393,504

Issue Date FY: 2006 ( Subtotal = $388,946 )
2006	2006	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	000	6	3/24/2006	NON-COMPETING CONTINUATION	$388,946
														Subtotal = $388,946

Issue Date FY: 2005 ( Subtotal = $400,346 )
2005	2005	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Mental Health Research Grants	000	5	7/1/2005	COMPETING CONTINUATION	$400,346
														Subtotal = $400,346

Issue Date FY: 2003 ( Subtotal = $323,930 ) (Continued on the next page)
Grand Total All Awards = $9,520,643

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Event-related Neuroimaging of Human Memory Formation

Award Number: R01MH060941

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/15/2000

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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