Sunday, May 11, 2025 5/11/2025

Central GLP1 Signaling Pathways and Anxiety

Award Number: R01MH059911
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Description

Central GLP1 Signaling Pathways and Anxiety - PROJECT SUMMARY/ABSTRACT Affective anxiety is characterized by behavioral inhibition accompanied by cognitive arousal and vigilance, reflecting a future-oriented emotional state. Anxiety is an adaptive response to perceived threat; however, chronic anxiety is debilitating, and anxiety disorders are the most common type of mental illness in the United States. Identification of neural circuits that underlie behavioral responses to threat in animal models is essential for understanding neurobiological mechanisms that contribute to normative and pathological anxiety in humans. Basic and clinical research has emphasized the importance of the central nucleus of the amygdala (CEA) and the anterolateral bed nucleus of stria terminalis (alBST) in regulating affective and physiological components of anxiety. The CEA and alBST are heavily interconnected and share many common sources of input, including input from caudal brainstem neurons that convey sensory feedback from body to brain; this feedback strongly modulates emotional state, including threat responses. The proposed research will test new hypotheses regarding the organization and behavioral role of CEA/alBST-projecting brainstem neurons that express glucagon-like peptide-1 (GLP1). GLP1 neurons are activated to express cFos in rats after acute threat, and GLP1 receptor signaling in the CEA/alBST increases arousal/vigilance and behavioral inhibition/avoidance in rats, akin to anxiety in humans. We recently developed a transgenic Sprague Dawley rat (Gcg-Cre) in which Cre is efficiently and selectively expressed by GLP1 neurons in the caudal nucleus of the solitary tract and intermediate reticular nucleus (i.e., NTS/IRtGLP1 neurons). Using validated viral tools and behavioral assays in this new model organism, we will conduct comparative analyses of the synaptic connectivity and functional role of NTS/IRtGLP1à CEA/alBST circuits in male and female Gcg-Cre rats, including documentation of potential sex differences. Since the distribution of GLP1 neurons in brainstem and GLP1 receptors in limbic forebrain appears similar in rats and humans, results from this basic science project have potential translational relevance for understanding neurobiological bases of normal and pathological symptoms of anxiety in humans.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $404,747 )
2024	2024	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Mental Health Research Grants	000	26	4/23/2024	NON-COMPETING CONTINUATION	$404,747
														Subtotal = $404,747

Issue Date FY: 2023 ( Subtotal = $426,644 )
2023	2023	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Mental Health Research Grants	000	25	4/25/2023	NON-COMPETING CONTINUATION	$426,644
														Subtotal = $426,644

Issue Date FY: 2022 ( Subtotal = $426,644 )
2022	2022	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Mental Health Research Grants	000	24	4/15/2022	NON-COMPETING CONTINUATION	$426,644
														Subtotal = $426,644

Issue Date FY: 2021 ( Subtotal = $426,644 )
2021	2021	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Mental Health Research Grants	000	23	5/5/2021	NON-COMPETING CONTINUATION	$426,644
2021	2020	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Mental Health Research Grants	002	22	7/3/2021	COMPETING CONTINUATION	$59,542
2021	2019	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Mental Health Research Grants	001	21	7/3/2021	NON-COMPETING CONTINUATION	-$59,542
														Subtotal = $426,644

Issue Date FY: 2020 ( Subtotal = $454,809 )
2020	2020	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Mental Health Research Grants	001	22	7/14/2020	COMPETING CONTINUATION	$454,809
2020	2019	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Mental Health Research Grants	000	21	7/7/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $454,809

Issue Date FY: 2019 ( Subtotal = $361,071 )
2019	2019	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Mental Health Research Grants	000	21	1/18/2019	NON-COMPETING CONTINUATION	$361,071
														Subtotal = $361,071

Issue Date FY: 2018 ( Subtotal = $360,369 )
2018	2018	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Mental Health Research Grants	002	20	1/26/2018	NON-COMPETING CONTINUATION	$324,332
2018	2018	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Mental Health Research Grants	003	20	6/15/2018	NON-COMPETING CONTINUATION	$36,037
2018	2017	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Mental Health Research Grants	001	19	12/11/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,460
2018	2016	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Mental Health Research Grants	000	17	12/11/2017	NON-COMPETING CONTINUATION	-$1,460
														Subtotal = $360,369

Issue Date FY: 2017 ( Subtotal = $377,357 )
2017	2017	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Mental Health Research Grants	002	18	6/12/2017	NON-COMPETING CONTINUATION	$0
2017	2017	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Mental Health Research Grants	001	18	6/6/2017	NON-COMPETING CONTINUATION	-$285,834
2017	2017	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Mental Health Research Grants	006	18	8/15/2017	NON-COMPETING CONTINUATION	-$53,961
2017	2017	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Mental Health Research Grants	003	19	6/12/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$321,512
2017	2017	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Mental Health Research Grants	004	19	7/10/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,884
2017	2017	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Mental Health Research Grants	007	19	8/15/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$202,339
2017	2017	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Mental Health Research Grants	000	18	1/20/2017	NON-COMPETING CONTINUATION	$339,795
2017	2016	UNIVERSITY OF PITTSBURGH THE	3520 FIFTH AVE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Mental Health Research Grants	005	17	8/15/2017	NON-COMPETING CONTINUATION	-$148,378
														Subtotal = $377,357

Issue Date FY: 2016 ( Subtotal = $377,767 )
2016	2016	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Mental Health Research Grants	000	17	1/22/2016	NON-COMPETING CONTINUATION	$377,767
														Subtotal = $377,767

Issue Date FY: 2015 ( Subtotal = $377,977 )
2015	2015	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Mental Health Research Grants	000	16	4/7/2015	COMPETING CONTINUATION	$377,977
														Subtotal = $377,977

Issue Date FY: 2013 ( Subtotal = $289,753 )
2013	2013	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Mental Health Research Grants	000	15	4/4/2013	NON-COMPETING CONTINUATION	$268,055
2013	2013	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Mental Health Research Grants	001	15	6/25/2013	NON-COMPETING CONTINUATION	$21,698
														Subtotal = $289,753

Issue Date FY: 2012 ( Subtotal = $361,630 )
2012	2012	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Mental Health Research Grants	000	14	3/7/2012	NON-COMPETING CONTINUATION	$361,630
														Subtotal = $361,630

Issue Date FY: 2011 ( Subtotal = $1 )
2011	2011	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Mental Health Research Grants	001	13	6/29/2011	NON-COMPETING CONTINUATION	$361,629
2011	2011	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Mental Health Research Grants	002	13	8/4/2011	NON-COMPETING CONTINUATION	-$361,629
2011	2011	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Mental Health Research Grants	000	13	4/8/2011	NON-COMPETING CONTINUATION	$1
														Subtotal = $1

Issue Date FY: 2010 ( Subtotal = $306,324 )
2010	2010	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Mental Health Research Grants	000	12	3/31/2010	NON-COMPETING CONTINUATION	$306,324
														Subtotal = $306,324

Issue Date FY: 2009 ( Subtotal = $365,283 )
2009	2009	UNIVERSITY OF PITTSBURGH	123 UNIVERSITY PLACE	PITTSBURGH	PA	15213	ALLEGHENY	USA	Mental Health Research Grants	001	11	6/17/2009	COMPETING CONTINUATION	$365,283
2009	2008	UNIVERSITY OF PITTSBURGH	3017 CATHEDRAL OF LEARNING	PITTSBURGH	PA	15260	ALLEGHENY	USA	Mental Health Research Grants	000	10	6/18/2009	NON-COMPETING CONTINUATION	$0
														Subtotal = $365,283

Issue Date FY: 2008 ( Subtotal = $275,581 )
2008	2008	UNIVERSITY OF PITTSBURGH	3017 CATHEDRAL OF LEARNING	PITTSBURGH	PA	15260	ALLEGHENY	USA	Mental Health Research Grants	000	10	3/25/2008	NON-COMPETING CONTINUATION	$275,581
														Subtotal = $275,581

Issue Date FY: 2007 ( Subtotal = $275,859 ) (Continued on the next page)
Grand Total All Awards = $7,423,901

Page 1 of 2 (67 items)12

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Central GLP1 Signaling Pathways and Anxiety

Award Number: R01MH059911

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer