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GENES, ENIVRONMENT AND THE ADJUSTMENT OF FAMILY MEMBERS

Award Number: R01MH054610
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: HEALTH SERVICES
PERIOD OF PERFORMANCE START DATE: 09/01/1996
PERIOD OF PERFORMANCE END DATE: 06/30/2007

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GENES, ENIVRONMENT AND THE ADJUSTMENT OF FAMILY MEMBERS - DESCRIPTION (provided by applicant): Studies that have examined genetic and environmental contributions to measures of family relationships and to associations between family relationships and mental health have found two different patterns of results for adults and children. For children, genetic factors explain most of the covariance between parent-child relationships and child adjustment, while in adults nonshared environmental factors account for most of the covariance between marital relationships and adult adjustment. These different patterns of findings suggest that different mechanisms are involved in linking pertinent family relationships to adjustment in children and adults. The proposed competitive renewal application seeks to extend the Twin Moms Project (R01 MH54610) to include a sample of twin fathers and their families (N=450 twin pairs and their families) and to collect an addition 125 pairs of twin mothers for a sample of 900 twin parents and their families (total N=2,700 individuals). This expanded sample will enable us to examine whether patterns of genetic and environmental influences on associations between family relationships and women's adjustment also hold for men. We will also be able to utilize the full twin families design in an effort to distinguish between different types of genotype-environment correlation for the associations between family relationships and child adjustment. As such, this information will enable us to understand better how and why relationships within the family affect the mental health of family members. We will collect data on family relationships, including parent-child, marital and siblings, on adult and child mental health, and on the individual attributes of family members. We will recruit 450 twin fathers who have at least one biological child from 11 to 20 years of age who resides with them at least half time, has been cohabitating with the same partner for at least 5 years, and whose cotwin also meets the above criterion. Twin parents, their partner and the target child will participate through questionnaires and an interview, using a multi-agent, multi-method strategy. This will enable us to examine the following specific aims: (1) examine the associations between parent-child and marital relationships and the mental health of women and men, (2) examine the associations between parent-child relationships and child mental health and explore possible mediators of these associations, and finally, (3) disentangle genetic, shared environmental and nonshared environmental influences for the associations identified in Specific Aims 1 and 2 using a twin family approach.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2006 ( Subtotal = $528,662 )
2006	2006	GEORGE WASHINGTON UNIVERSITY	2100 M STREET, NW, SUITE 310	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Mental Health Research Grants	000	9	6/13/2006	NON-COMPETING CONTINUATION	$528,662
														Subtotal = $528,662

Issue Date FY: 2005 ( Subtotal = $540,573 )
2005	2005	GEORGE WASHINGTON UNIVERSITY	2100 M STREET, NW, SUITE 310	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Mental Health Research Grants	000	8	7/1/2005	NON-COMPETING CONTINUATION	$540,573
														Subtotal = $540,573

Issue Date FY: 2004 ( Subtotal = $540,058 )
2004	2004	GEORGE WASHINGTON UNIVERSITY	2100 M STREET, NW, SUITE 310	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Mental Health Research Grants	000	7	5/20/2004	NON-COMPETING CONTINUATION	$540,058
														Subtotal = $540,058

Issue Date FY: 2003 ( Subtotal = $527,216 )
2003	2003	GEORGE WASHINGTON UNIVERSITY	2100 M STREET, NW, SUITE 310	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Mental Health Research Grants	000	6	7/9/2003	NON-COMPETING CONTINUATION	$527,216
														Subtotal = $527,216

Issue Date FY: 2002 ( Subtotal = $565,122 )
2002	2002	GEORGE WASHINGTON UNIVERSITY	2100 M STREET, NW, SUITE 310	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Mental Health Research Grants	000	5	8/15/2002	COMPETING CONTINUATION	$565,122
														Subtotal = $565,122

Issue Date FY: 1999 ( Subtotal = $236,985 )
1999	1999	GEORGE WASHINGTON UNIVERSITY	44983 KNOLL SQUARE	ASHBURN	VA	20147	LOUDOUN	USA	Mental Health Research Grants	000	4	4/19/1999	NON-COMPETING CONTINUATION	$236,985
														Subtotal = $236,985

Issue Date FY: 1998 ( Subtotal = $393,436 )
1998	1998	GEORGE WASHINGTON UNIVERSITY	44983 KNOLL SQUARE	ASHBURN	VA	20147	LOUDOUN	USA	Mental Health Research Grants	000	3	5/11/1998	NON-COMPETING CONTINUATION	$393,436
														Subtotal = $393,436

Grand Total All Awards = $3,332,052

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GENES, ENIVRONMENT AND THE ADJUSTMENT OF FAMILY MEMBERS

Award Number: R01MH054610

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: HEALTH SERVICES

PERIOD OF PERFORMANCE START DATE: 09/01/1996

PERIOD OF PERFORMANCE END DATE: 06/30/2007

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