Thursday, December 26, 2024 12/26/2024

Differential Resilience in Models of Neurons and Circuits with Similar Outputs

Award Number: R01MH046742
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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View Award Abstract

All animals need to be resilient to perturbations in their internal and external environments. Mechanisms that ensure or promote resilience must exist on a large variety of time scales, from milliseconds to years for long-lived animals such as humans. Moreover, many psychiatric disorders may be expressed as a lack of resilience to a variety of stresses, so understanding the fundamental principles and cellular mechanisms that promote resilience in individuals and the population will provide a set of backbone concepts that will inform our understanding of the loss of resilience seen in mental illnesses. This computational/theoretical project will explore a number of hypotheses and potential mechanisms that may contribute to increasing the resilience of neurons and circuits to perturbation. Specific Aim #1 will explore the hypothesis that neurons with multiple voltage-dependent currents with overlapping properties will be more resilient to perturbation than neurons with fewer currents. Specific Aim #2 will characterize and explore the dynamic range of small reciprocally inhibitory circuits in response to perturbation. Of particular interest is whether resilience at one level of organization percolates to the next level. Specific Aim #3 will study a newly refined model of homeostatic tuning of intrinsic excitability and determine if homeostatic changes in response to a single, short-term perturbation result in changes of resilience towards repeat presentations of the same perturbation or qualitatively different perturbations. These studies may provide insight into how repeated insults “accrue” to produce long-term changes in mental health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $406,250 )
2024	2024	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Mental Health Research Grants	001	34	8/15/2024	NON-COMPETING CONTINUATION	$40,625
2024	2024	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Mental Health Research Grants	000	34	3/12/2024	NON-COMPETING CONTINUATION	$365,625
														Subtotal = $406,250

Issue Date FY: 2023 ( Subtotal = $406,250 )
2023	2023	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Mental Health Research Grants	000	33	3/29/2023	NON-COMPETING CONTINUATION	$406,250
														Subtotal = $406,250

Issue Date FY: 2022 ( Subtotal = $406,250 )
2022	2022	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Mental Health Research Grants	003	32	3/9/2022	NON-COMPETING CONTINUATION	$365,625
2022	2022	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Mental Health Research Grants	004	32	5/10/2022	NON-COMPETING CONTINUATION	$40,625
2022	2021	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Mental Health Research Grants	002	31	3/4/2022	COMPETING CONTINUATION	$0
2022	2021	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Mental Health Research Grants	001	31	2/14/2022	COMPETING CONTINUATION	$57,002
2022	2019	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Mental Health Research Grants	000	30	2/14/2022	NON-COMPETING CONTINUATION	-$57,002
														Subtotal = $406,250

Issue Date FY: 2021 ( Subtotal = $406,250 )
2021	2021	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Mental Health Research Grants	000	31	4/2/2021	COMPETING CONTINUATION	$406,250
														Subtotal = $406,250

Issue Date FY: 2019 ( Subtotal = $418,984 )
2019	2019	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Mental Health Research Grants	000	30	3/16/2019	NON-COMPETING CONTINUATION	$418,984
														Subtotal = $418,984

Issue Date FY: 2018 ( Subtotal = $418,984 )
2018	2018	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Mental Health Research Grants	000	29	4/19/2018	NON-COMPETING CONTINUATION	$418,984
														Subtotal = $418,984

Issue Date FY: 2017 ( Subtotal = $418,984 )
2017	2017	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Mental Health Research Grants	000	28	3/4/2017	NON-COMPETING CONTINUATION	$377,085
2017	2017	BRANDEIS UNIVERSITY	415 SOUTH ST	WALTHAM	MA	02453	MIDDLESEX	USA	Mental Health Research Grants	001	28	7/25/2017	NON-COMPETING CONTINUATION	$41,899
														Subtotal = $418,984

Issue Date FY: 2016 ( Subtotal = $418,984 )
2016	2016	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Mental Health Research Grants	000	27	4/12/2016	NON-COMPETING CONTINUATION	$418,984
														Subtotal = $418,984

Issue Date FY: 2015 ( Subtotal = $480,862 )
2015	2015	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Mental Health Research Grants	002	26	3/27/2015	COMPETING CONTINUATION	$0
2015	2015	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Mental Health Research Grants	001	26	3/17/2015	COMPETING CONTINUATION	$480,862
2015	2014	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Mental Health Research Grants	000	25	3/12/2015	NON-COMPETING CONTINUATION	$0
														Subtotal = $480,862

Issue Date FY: 2014 ( Subtotal = $391,050 )
2014	2014	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Mental Health Research Grants	000	25	12/24/2013	NON-COMPETING CONTINUATION	$351,945
2014	2014	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Mental Health Research Grants	001	25	4/25/2014	NON-COMPETING CONTINUATION	$39,105
														Subtotal = $391,050

Issue Date FY: 2013 ( Subtotal = $375,408 )
2013	2013	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Mental Health Research Grants	001	24	6/27/2013	NON-COMPETING CONTINUATION	$23,463
2013	2013	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Mental Health Research Grants	000	24	11/19/2012	NON-COMPETING CONTINUATION	$351,945
														Subtotal = $375,408

Issue Date FY: 2012 ( Subtotal = $391,050 )
2012	2012	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Mental Health Research Grants	000	23	11/30/2011	NON-COMPETING CONTINUATION	$351,945
2012	2012	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Mental Health Research Grants	001	23	3/15/2012	NON-COMPETING CONTINUATION	$39,105
														Subtotal = $391,050

Issue Date FY: 2011 ( Subtotal = $391,050 )
2011	2011	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Mental Health Research Grants	001	22	6/30/2011	NON-COMPETING CONTINUATION	$35,550
2011	2011	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Mental Health Research Grants	000	22	3/17/2011	NON-COMPETING CONTINUATION	$355,500
														Subtotal = $391,050

Issue Date FY: 2010 ( Subtotal = $395,000 )
2010	2010	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Mental Health Research Grants	000	21	3/5/2010	COMPETING CONTINUATION	$395,000
														Subtotal = $395,000

Issue Date FY: 2009 ( Subtotal = $325,780 )
2009	2009	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02453	MIDDLESEX	USA	Mental Health Research Grants	000	20	4/23/2009	NON-COMPETING CONTINUATION	$325,780
														Subtotal = $325,780

Issue Date FY: 2008 ( Subtotal = $325,780 )
2008	2008	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Mental Health Research Grants	000	19	4/3/2008	NON-COMPETING CONTINUATION	$325,780
														Subtotal = $325,780

Issue Date FY: 2007 ( Subtotal = $325,780 )
2007	2007	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Mental Health Research Grants	000	18	4/24/2007	NON-COMPETING CONTINUATION	$325,780
														Subtotal = $325,780

Issue Date FY: 2006 ( Subtotal = $335,510 )
2006	2006	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Mental Health Research Grants	000	17	4/14/2006	NON-COMPETING CONTINUATION	$335,510
														Subtotal = $335,510

Issue Date FY: 2005 ( Subtotal = $343,584 )
2005	2005	BRANDEIS UNIVERSITY	415 SO ST, 119 BERNSTEIN-MARCU	WALTHAM	MA	02254		USA	Mental Health Research Grants	000	16	3/17/2005	COMPETING CONTINUATION	$343,584
														Subtotal = $343,584

Grand Total All Awards = $7,381,790

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Differential Resilience in Models of Neurons and Circuits with Similar Outputs

Award Number: R01MH046742

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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