Wednesday, February 5, 2025 2/5/2025

Development and Regulation of Emotion in Primates

Award Number: R01MH046729
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY – New treatments for anxiety disorders are critically needed as numerous individuals fail to respond to current treatments. A more complete understanding of pathological anxiety at the molecular, cellular and circuit levels will provide a foundation for new treatment development. In this regard, nonhuman primate (NHP) models are invaluable for understanding mechanisms underlying maladaptive anxiety relevant to stress-related psychopathology. An important recent advance is the use of chemogenetic methods to modulate the primate amygdala. This work serves as an initial foundation for treatment development directed at the regulation of subcortical regions relevant to the pathophysiology of psychiatric disorders. As a translational bridge, our laboratory employs methods that provide an in-depth mechanistic understanding of brain alterations associated with extreme anxiety, including behavioral phenotyping, functional and structural neuroimaging, RNA sequencing and viral vector-mediated gene delivery. Findings from our chemogenetic studies using Designer Receptors Exclusively Activation by Designer Drugs (DREADDs) point to basolateral amygdala (BLA) neurons as potential treatment targets. The BLA processes threat-related information received from cortical and subcortical sources and transmits this information to the extended amygdala (central nucleus of the amygdala (Ce) and bed nucleus of the stria terminalis), which activates threat- related responses via its downstream targets. Within the BLA, inhibitory interneurons modulate the function and output of longer-range projecting excitatory neurons, which project to the Ce, other subcortical structures, and posterior orbitofrontal cortex (pOFC). The overall aims of this proposal are to further understand the implications of amygdala modulation in relation to treatment development focusing on BLA neurons. Neuroimaging and RNA sequencing (RNA-Seq) will provide insights into mechanisms related to therapeutic efficacy. Additionally, these studies will serve as a proof-of-concept to understand the feasibility of developing chemogenetic approaches for the future treatment of severe and refractory psychiatric disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $627,215 )
2025	2025	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	000	31	1/8/2025	NON-COMPETING CONTINUATION	$627,215
														Subtotal = $627,215

Issue Date FY: 2024 ( Subtotal = $737,567 )
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	001	30	7/16/2024	NON-COMPETING CONTINUATION	$73,757
2024	2024	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	000	30	1/24/2024	NON-COMPETING CONTINUATION	$663,810
														Subtotal = $737,567

Issue Date FY: 2023 ( Subtotal = $747,389 )
2023	2023	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	001	29	3/2/2023	NON-COMPETING CONTINUATION	$747,389
2023	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	000	27	12/5/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $747,389

Issue Date FY: 2022 ( Subtotal = $766,910 )
2022	2022	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	001	28	4/1/2022	COMPETING CONTINUATION	$766,910
2022	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6301	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	000	27	3/31/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $766,910

Issue Date FY: 2021 ( Subtotal = $923,340 )
2021	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	000	27	1/28/2021	NON-COMPETING CONTINUATION	$744,755
2021	2021	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	001	27	7/7/2021	SUPPLEMENT FOR EXPANSION	$178,585
														Subtotal = $923,340

Issue Date FY: 2020 ( Subtotal = $866,122 )
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	000	26	1/29/2020	NON-COMPETING CONTINUATION	$739,797
2020	2020	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	001	26	9/18/2020	SUPPLEMENT FOR EXPANSION	$126,325
														Subtotal = $866,122

Issue Date FY: 2019 ( Subtotal = $726,585 )
2019	2019	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	000	25	1/18/2019	NON-COMPETING CONTINUATION	$726,585
														Subtotal = $726,585

Issue Date FY: 2018 ( Subtotal = $730,074 )
2018	2018	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	000	24	1/18/2018	NON-COMPETING CONTINUATION	$657,067
2018	2018	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	005	24	6/15/2018	NON-COMPETING CONTINUATION	$73,007
2018	2017	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	004	23	2/13/2018	COMPETING CONTINUATION	$2,164
2018	2016	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	003	22	2/13/2018	EXTENSION WITH OR WITHOUT FUNDS	-$2,164
2018	2016	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	002	22	2/12/2018	EXTENSION WITH OR WITHOUT FUNDS	$2,164
2018	2015	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	001	21	2/12/2018	NON-COMPETING CONTINUATION	-$2,164
														Subtotal = $730,074

Issue Date FY: 2017 ( Subtotal = $782,066 )
2017	2017	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	002	23	9/7/2017	COMPETING CONTINUATION	$14,063
2017	2017	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	000	23	1/30/2017	COMPETING CONTINUATION	$782,066
2017	2016	UNIVERSITY OF WISCONSIN SYSTEM	21 N PARK ST STE 6401	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	001	22	9/7/2017	EXTENSION WITH OR WITHOUT FUNDS	-$14,063
														Subtotal = $782,066

Issue Date FY: 2016 ( Subtotal = $629,439 )
2016	2016	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	000	22	3/15/2016	EXTENSION WITH OR WITHOUT FUNDS	$629,439
														Subtotal = $629,439

Issue Date FY: 2015 ( Subtotal = $632,500 )
2015	2015	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	000	21	6/29/2015	NON-COMPETING CONTINUATION	$632,500
														Subtotal = $632,500

Issue Date FY: 2014 ( Subtotal = $629,176 )
2014	2014	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	000	20	6/14/2014	NON-COMPETING CONTINUATION	$629,176
														Subtotal = $629,176

Issue Date FY: 2013 ( Subtotal = $611,733 )
2013	2013	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	000	19	7/9/2013	NON-COMPETING CONTINUATION	$611,733
														Subtotal = $611,733

Issue Date FY: 2012 ( Subtotal = $640,891 )
2012	2012	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	000	18	6/15/2012	COMPETING CONTINUATION	$640,891
														Subtotal = $640,891

Issue Date FY: 2009 ( Subtotal = $535,504 )
2009	2009	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 N PARK ST	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	000	17	7/13/2009	NON-COMPETING CONTINUATION	$535,504
														Subtotal = $535,504

Issue Date FY: 2008 ( Subtotal = $519,905 )
2008	2008	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 NORTH PARK STREET	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	000	16	6/13/2008	NON-COMPETING CONTINUATION	$519,905
														Subtotal = $519,905

Issue Date FY: 2007 ( Subtotal = $519,839 )
2007	2007	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	21 NORTH PARK STREET	MADISON	WI	53715	DANE	USA	Mental Health Research Grants	000	15	8/15/2007	NON-COMPETING CONTINUATION	$519,839
														Subtotal = $519,839

Issue Date FY: 2006 ( Subtotal = $519,773 )
2006	2006	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	750 UNIVERSITY AVENUE	MADISON	WI	53706	DANE	USA	Mental Health Research Grants	000	14	6/19/2006	NON-COMPETING CONTINUATION	$519,773
														Subtotal = $519,773

Issue Date FY: 2005 ( Subtotal = $516,778 )
2005	2005	UNIVERSITY OF WISCONSIN SYSTEM/BOARD OF REGENTS	750 UNIVERSITY AVENUE	MADISON	WI	53706	DANE	USA	Mental Health Research Grants	000	13	8/11/2005	COMPETING CONTINUATION	$516,778
														Subtotal = $516,778

Grand Total All Awards = $15,014,011

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Development and Regulation of Emotion in Primates

Award Number: R01MH046729

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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