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American Indian/Alaska Native Tailoring of a Home-Based Cervical and Colorectal Cancer Screening Program (AT-HOME)

Award Number: R01MD021852
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 11/30/2030

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American Indian/Alaska Native Tailoring of a Home-Based Cervical and Colorectal Cancer Screening Program (AT-HOME) - PROJECT SUMMARY Participating in screening programs can decrease morbidity and mortality from cervical cancer (CC) and colorectal cancer (CRC) by diagnosing cancer and pre-cancerous conditions at an early, curable stage. American Indian/Alaska Native (AI/AN) people have the worst 5-year cancer survival rates of all racial/ethnic groups in the U.S., and AI/ANs have nearly twice the incidence of CC and 6% higher rate of CRC compared to NWH individuals. CC and CRC screening allows for early detection and treatment, but is underused in the AI/AN population with screening rates well below the national average. Home-based testing options supported by population outreach strategies could overcome common barriers for CC and CRC screening. These Food and Drug Administration (FDA) approved options for home-based testing for CC and CRC screening are completed through self-swabbing for high-risk human papillomavirus (HPV) and fecal immunochemical testing (FIT) to screen for CRC. Culturally tailored educational interventions incorporating home-based testing and aligning messages with AI/AN cultural values may reduce barriers faced by AI/AN individuals to screening. We will adapt cancer screening outreach methods through cultural tailoring and incorporating self- collections options into existing CC and CRC screening programs in the proposed study, AI/AN Tailoring of a Home-Based CC and CRC Screening Program (i.e., AT-HOME). AT-HOME is a collaboration between the Oregon Rural Practice-based Research Network and the Knight Cancer Institute at Oregon Health & Science University, and two Tribal health systems in Oregon serving over 10,000 Tribal members in two rural regions. In AT-HOME, will develop and test an outreach approach for AI/AN Tribal communities through three aims: 1) Tailor the AT-HOME intervention with community stakeholders to align with local AI/AN cultural priorities and contexts using an approach that looks at the specific setting and context of screening activities; 2) Implement the AT-HOME intervention with two Tribal clinic partners and evaluate its impact on participation in cervical and colorectal cancer screening with a primary outcome of change in screening rates before and after the intervention; and 3) Evaluate the AT-HOME intervention using a framework that measures the Reach, Effectiveness, Adoption/Implementation, and Maintenance (RE-AIM) of the intervention. We expect to have a tailored, culturally appropriate CC and CRC screening media and an outreach program aligned with local AI/AN priorities that incorporates home-based screening into cancer screening in these communities. Our long- term goal is to reduce mortality from CC and CRC among AI/ANs by increasing cancer screening participation. Our work could have wide-spread impact by providing a sustainable template for other Tribal Nations to tailor screening programs and reduce mortality from CC and CRC across Indian Country. Cancer prevention and health promotion research is most meaningful when advances in science are shared and implemented in the community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2027 ( Subtotal = $0 )
2027	2026	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Minority Health and Health Disparities Research	000	1	10/8/2026	NEW	$0
														Subtotal = $0

Issue Date FY: 2026 ( Subtotal = $3,117,935 )
2026	2026	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Minority Health and Health Disparities Research	000	1	8/28/2026	NEW	$3,117,935
														Subtotal = $3,117,935

Grand Total All Awards = $3,117,935

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American Indian/Alaska Native Tailoring of a Home-Based Cervical and Colorectal Cancer Screening Program (AT-HOME)

Award Number: R01MD021852

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 11/30/2030

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