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Diabetes Prevention through Genetics, Familial History and Behavior Change

Award Number: R01MD021606
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/16/2026
PERIOD OF PERFORMANCE END DATE: 01/31/2031

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Diabetes Prevention through Genetics, Familial History and Behavior Change - Type 2 diabetes (T2D) affects 38.4 million U.S. adults, with 97.6 million at risk due to prediabetes, and that burden concentrates in racially/ethnic families or those living in rural communities, or both. Diagnosed diabetes prevalence among Black/African American, Hispanic/Latino, and American Indian/Alaska Native adults is roughly 1.5-2 times that of non-Hispanic White adults, and prediabetes prevalence in rural communities exceeds urban communities by 17%. Although the Diabetes Prevention Program (DPP) effectively reduces T2D incidence, adherence is highly variable and remains the strongest predictor of outcomes. Current DPP delivery emphasizes the individual, overlooking the family context, which strongly influences behavior change. Family health history (FHH) increases T2D risk 2.5-4.5-fold and motivates preventive action, yet structured FHH collection and family participation have not been integrated into DPP interventions. Our central hypothesis is that embedding family engagement and FHH assessment into the DPP will improve adherence, weight loss, and glycemic outcomes. Specific Aim 1 will systematically adapt existing curricula to develop a 6-session family component integrating comprehensive FHH collection using the validated CDC My Family Health Portrait tool and personalized T2D risk communication, with mixed-methods formative testing among 40 index participants and family members across rural and urban sites. Specific Aim 2 will conduct a 2- arm randomized controlled trial with 200 index participants with prediabetes plus their family members, stratified by geographical location and block randomized to receive either adapted DPP with family components or standard DPP. Primary outcomes include weight loss percentage, HbA1c reduction, and session attendance rates at 6 and 12 months. Specific Aim 3 will evaluate family outcomes and mechanisms of change using the Actor-Partner Interdependence Model to test whether health improvements extend beyond index participants and identify moderators explaining variation in family-level outcomes. The impact of this project directly addresses adherence barriers by leveraging family context within a multilevel prevention framework consistent with NIMHD priorities. The expected outcome is a scalable, family-centered model that strengthens DPP impact and advances diabetes prevention across rural and urban populations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $702,086 )
2026	2026	THE MOREHOUSE SCHOOL OF MEDICINE, INC.	720 WESTVIEW DR SW	ATLANTA	GA	30310	FULTON	USA	Minority Health and Health Disparities Research	000	1	8/18/2026	NEW	$702,086
														Subtotal = $702,086

Grand Total All Awards = $702,086

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Diabetes Prevention through Genetics, Familial History and Behavior Change

Award Number: R01MD021606

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/16/2026

PERIOD OF PERFORMANCE END DATE: 01/31/2031

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