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Factors Influencing Pediatric Asthma into Adulthood (FIPA2)

Award Number: R01MD019027
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/25/2023
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Factors Influencing Pediatric Asthma into Adulthood (FIPA2) - Title: FIPA2 M-PI: Best/Erdei/Torgerson Project Summary Pediatric asthma in American Indian (AI) communities of the Northern Plains Region presents a serious health disparity. While many previous works carried out in minority communities – but not in AI children- looked at individual level of influences on pediatric asthma and made parents responsible for asthma control, our study will bring together a more comprehensive and realistic framework. Our novel approach will move the study from the collected data toward Tribal health policy change. The FIPA2 study is designed to leverage the previously NIMHD-funded Factors Influencing Pediatric Asthma study (U54MD008164) which successfully enrolled 324 Cheyenne River Sioux Tribal (CRST) children (age 6-17 years) in 2013-2017. That study also had a randomized educational clinical trial component (NCT 03302962) and we documented results of that work. In the FIPA2 study, we will examine the complex interplay between social, environmental and immunological response to viral respiratory infections an gap in knowledge that remains largely unknown. In this continued AI community-focused pediatric asthma study, we will test the hypothesis that AI children with asthma have alterations in immunological response to several viral respiratory infections as compared to those without asthma. We will also investigate whether social and environmental factors (SEF) significantly contribute to this disparity through stressed-induced modification of immune state. We will explore the role of viral respiratory infections (RSV, rhinovirus C, and influenza A and B) and SEF on asthma severity, including frequency of exacerbations, ER visits/hospitalizations, and use of asthma medications. Aim 1 will identify social and environmental factors (SEF) that contribute to asthma susceptibility, severity and long-term respiratory health. Participants will be enrolled at our Missouri Breaks Industries Research Inc. main office by working with Reservation communities. To achieve enrollment goals, we will also enroll in Rapid City, SD, an urban setting where AIs also located (12.4% of the city’s population). In Aim 2, we will examine the role of SEF on immunological and clinical response to viral respiratory infections (VRIs) in AI children with and without asthma. We will test our hypothesis that interactions with detailed survey measures of SEF with immunological and clinical outcomes of VRIs, including seasonality of viral responses in participants with and without asthma are the strongest and most significant predictors in our AI participants. Aim 3 will bring a comprehensive and vivid community input to this study and will benefit from our local community advisory board (CAB) that supports the study. We will rely on our own, experienced CBPR-based and bidirectional process evaluation. We will create a feasible and community-driven asthma prevention framework that will be effective and can be applied in other AI communities as well.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $543,377 )
2025	2025	MISSOURI BREAKS INDUSTRIES RESEARCH, INC	505 S WILLOW ST	EAGLE BUTTE	SD	57625	DEWEY	USA	Minority Health and Health Disparities Research	002	3	4/30/2025	NON-COMPETING CONTINUATION	$543,377
2025	2024	MISSOURI BREAKS INDUSTRIES RESEARCH, INC	505 S WILLOW ST	EAGLE BUTTE	SD	57625	DEWEY	USA	Minority Health and Health Disparities Research	001	2	4/30/2025	NON-COMPETING CONTINUATION	$0
2025	2024	MISSOURI BREAKS INDUSTRIES RESEARCH, INC	505 S WILLOW ST	EAGLE BUTTE	SD	57625	DEWEY	USA	Minority Health and Health Disparities Research	000	2	3/28/2025	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $543,377

Issue Date FY: 2024 ( Subtotal = $645,858 )
2024	2024	MISSOURI BREAKS INDUSTRIES RESEARCH, INC	505 S WILLOW ST	EAGLE BUTTE	SD	57625	DEWEY	USA	Minority Health and Health Disparities Research	001	2	4/30/2024	NON-COMPETING CONTINUATION	$525,404
2024	2024	MISSOURI BREAKS INDUSTRIES RESEARCH, INC	505 S WILLOW ST	EAGLE BUTTE	SD	57625	DEWEY	USA	Minority Health and Health Disparities Research	002	2	9/21/2024	SUPPLEMENT FOR EXPANSION	$120,454
2024	2023	MISSOURI BREAKS INDUSTRIES RESEARCH, INC.	118 S WILLOW ST	EAGLE BUTTE	SD	57625	DEWEY	USA	Minority Health and Health Disparities Research	000	1	11/30/2023	NEW	$0
														Subtotal = $645,858

Issue Date FY: 2023 ( Subtotal = $551,650 )
2023	2023	MISSOURI BREAKS INDUSTRIES RESEARCH, INC.	118 S WILLOW ST	EAGLE BUTTE	SD	57625	DEWEY	USA	Minority Health and Health Disparities Research	001	1	9/27/2023	NEW	$0
2023	2023	MISSOURI BREAKS INDUSTRIES RESEARCH, INC.	118 S WILLOW ST	EAGLE BUTTE	SD	57625	DEWEY	USA	Minority Health and Health Disparities Research	000	1	9/25/2023	NEW	$551,650
														Subtotal = $551,650

Grand Total All Awards = $1,740,885

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Factors Influencing Pediatric Asthma into Adulthood (FIPA2)

Award Number: R01MD019027

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/25/2023

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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