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Examining the Relationship between Residential History at Midlife and Prostate Cancer Outcomes

Award Number: R01MD018146
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Examining the Relationship between Residential History at Midlife and Prostate Cancer Outcomes - ABSTRACT Prostate cancer (PCa) is one of a few cancers with more than double the mortality for black men, making this one of the greatest racial disparities in cancer. Although there are documented disparities in PCa incidence and mortality related to where people live, it is unclear how residential histories of patients contribute to their PCa outcomes. Residential environments vary greatly by race and socioeconomics (SES). Still little is known about how longitudinal exposures to neighborhood risk factors and structural racism captured years before a cancer diagnosis and into survivorship contribute to PCa disparities along the cancer care continuum. Additionally, disease outcomes and disparities in PCa are moderated by patient age. Residential history during midlife is one of the factors that likely influences PCa incidence, progression, mortality, and overall care of survivors. We propose an innovative linkage of PA cancer registry data to hospital billing records from the PA Healthcare Cost Containment Council and ~30 years of LexisNexis address data to provide characteristics of census tracts where patients live. We will use Pennsylvania (PA) Cancer Registry data (N~20,000 patients in Southeastern PA) to determine the relationship between longitudinal neighborhood characteristics (poverty trajectories, historical redlining, lending bias, and gentrification) and PCa outcomes at critical points along the cancer care continuum in a diverse and historic region. These various characteristics will be used to determine best practices to examine residential histories in risk modeling for PCa outcomes. We will take a novel life course approach to addressing the role of residential history on PCa disparities. We hypothesize that cumulative exposures as well as exposures to neighborhood risk factors during critical periods in the PCa care trajectory influence disease characteristics at diagnosis and PCa-mortality. Multilevel regression models will be conducted to evaluate independent associations of multi-level factors with PCa outcomes. We will also examine modification by age. The information that we learn from this study will help us to understand ways to integrate residential history in cancer research and strategize about effective interventions to promote prostate health among high-risk adult populations We propose a longitudinal, ambidirectional study to address the following aims: Aim 1: To examine the relationships between PCa disparities and residential characteristics at diagnosis; Aim 2: To We will employ a life-course framework in this examine relationships between PCa disparities and accumulated cancer disparities research (based on Ory, et al. residential history; Aim 3: To examine how residential exposures 2014, AJPM). Disparities occur within an accumulated specifically during midlife are associated with PCa environmental context. Research focused on disparities; Aim 4: Conduct a community needs assessment in particular life stages provide unique opportunities partnership with expert clinician and community planning stakeholders to inform policy, practice, and the health of the to improve PCa outreach and care community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $512,007 )
2025	2025	THE INSTITUTE FOR CANCER RESEARCH	333 COTTMAN AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Minority Health and Health Disparities Research	002	3	4/18/2025	NON-COMPETING CONTINUATION	$512,007
2025	2024	THE INSTITUTE FOR CANCER RESEARCH	333 COTTMAN AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Minority Health and Health Disparities Research	001	2	4/18/2025	NON-COMPETING CONTINUATION	$0
2025	2024	THE INSTITUTE FOR CANCER RESEARCH	333 COTTMAN AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Minority Health and Health Disparities Research	000	2	3/7/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $512,007

Issue Date FY: 2024 ( Subtotal = $507,193 )
2024	2024	THE INSTITUTE FOR CANCER RESEARCH	333 COTTMAN AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Minority Health and Health Disparities Research	000	2	2/14/2024	NON-COMPETING CONTINUATION	$470,592
2024	2024	THE INSTITUTE FOR CANCER RESEARCH	333 COTTMAN AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Minority Health and Health Disparities Research	001	2	6/13/2024	NON-COMPETING CONTINUATION	$36,601
														Subtotal = $507,193

Issue Date FY: 2023 ( Subtotal = $542,620 )
2023	2023	INSTITUTE FOR CANCER RESEARCH, THE	333 COTTMAN AVE	PHILADELPHIA	PA	19111	PHILADELPHIA	USA	Minority Health and Health Disparities Research	000	1	8/16/2023	NEW	$542,620
														Subtotal = $542,620

Grand Total All Awards = $1,561,820

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Examining the Relationship between Residential History at Midlife and Prostate Cancer Outcomes

Award Number: R01MD018146

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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