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Eliminating racial disparities in severe maternal morbidity by addressing hypertension in the year after delivery

Award Number: R01MD017083
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/30/2022
PERIOD OF PERFORMANCE END DATE: 04/30/2027

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Eliminating racial disparities in severe maternal morbidity by addressing hypertension in the year after delivery - PROJECT ABSTRACT The increasing rate of severe maternal morbidity and mortality events in the U.S. affects Black women. Black women are 3 to 4 times more likely than white women to die from complications during or after pregnancy. Hypertensive disorders of pregnancy (HDP) (e.g., preeclampsia, gestational hypertension) are major contributors to severe maternal morbidity and mortality, as well as long-term cardiovascular disease (CVD). Black women are more likely than white women to have severe forms of HDP and severe post-partum complications such as chronic hypertension, stroke and CVD. We have compelling preliminary data that documents racial disparities in the post-partum blood pressure recovery profile among women with HDP at 6 weeks and 12 months after delivery. Despite an overall downward trend in post-partum blood pressures among women with HDP, Black women have higher blood pressures and are more likely to have stage 2 hypertension (≥140/90 mmHg) at 6 weeks postpartum compared to white women (32.4% versus.18.2%, p <0.001); trends that persist to one year after delivery. We propose to decrease the racial disparity in blood pressure control at one year postpartum among all women with HDP by leveraging our hospital-initiated 6-week home blood pressure monitoring program (HBPM) for women with HDP and our novel community-partnered multi-level intervention with Healthy Start Inc. We aim to: 1) test an enhanced care intervention strategy (6 weeks of HBPM, postpartum doula education and support, 12 months of wireless HBPM and weight monitoring) compared to usual care control (6 weeks of HBPM) to improve the blood pressure profile among women with HDP; 2) determine if an enhanced care strategy will eliminate racial disparities in BP profiles, and 3) determine the access to and delivery of guideline-concordant clinical care that is essential for all women to successfully recover from HDP within one year postpartum. We hypothesize that the enhanced care intervention rooted within a multilevel framework will improve the post-partum blood pressure recovery profile and close the disparity in blood pressure among women with HDP in the year after delivery. Our approach will be to conduct a parallel, two-arm trial that randomizes 454 women with HDP (75% Black, 25% White) into usual care or an enhanced care intervention to improve blood pressure control in the year after delivery. Improving blood pressure control is essential to prevent progression to chronic hypertension, reduce racial disparities in hypertension, and improve women’s health overall.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $555,493 )
2026	2026	MAGEE-WOMENS RESEARCH INSTITUTE AND FOUNDATION	3240 CRAFT PL STE 100	PITTSBURGH	PA	15213	ALLEGHENY	USA	Minority Health and Health Disparities Research	000	5	6/12/2026	NON-COMPETING CONTINUATION	$555,493
														Subtotal = $555,493

Issue Date FY: 2025 ( Subtotal = $564,270 )
2025	2025	MAGEE-WOMENS RESEARCH INSTITUTE AND FOUNDATION	3240 CRAFT PL STE 100	PITTSBURGH	PA	15213	ALLEGHENY	USA	Minority Health and Health Disparities Research	000	4	8/1/2025	NON-COMPETING CONTINUATION	$564,270
														Subtotal = $564,270

Issue Date FY: 2024 ( Subtotal = $551,784 )
2024	2024	MAGEE-WOMENS RESEARCH INSTITUTE AND FOUNDATION	3240 CRAFT PL STE 100	PITTSBURGH	PA	15213	ALLEGHENY	USA	Minority Health and Health Disparities Research	000	3	5/3/2024	NON-COMPETING CONTINUATION	$551,784
														Subtotal = $551,784

Issue Date FY: 2023 ( Subtotal = $579,852 )
2023	2023	MAGEE-WOMENS RESEARCH INSTITUTE AND FOUNDATION	3339 WARD ST	PITTSBURGH	PA	15213	ALLEGHENY	USA	Minority Health and Health Disparities Research	003	2	4/22/2023	NON-COMPETING CONTINUATION	$579,852
2023	2022	MAGEE-WOMENS RESEARCH INSTITUTE AND FOUNDATION	3339 WARD ST	PITTSBURGH	PA	15213	ALLEGHENY	USA	Minority Health and Health Disparities Research	001	1	2/21/2023	NEW	$0
2023	2022	MAGEE-WOMENS RESEARCH INSTITUTE AND FOUNDATION	3339 WARD ST	PITTSBURGH	PA	15213	ALLEGHENY	USA	Minority Health and Health Disparities Research	000	1	11/18/2022	NEW	$0
2023	2022	MAGEE-WOMENS RESEARCH INSTITUTE AND FOUNDATION	3339 WARD ST	PITTSBURGH	PA	15213	ALLEGHENY	USA	Minority Health and Health Disparities Research	002	1	2/23/2023	NEW	$0
														Subtotal = $579,852

Issue Date FY: 2022 ( Subtotal = $632,932 )
2022	2022	MAGEE-WOMENS RESEARCH INSTITUTE AND FOUNDATION	3339 WARD ST	PITTSBURGH	PA	15213	ALLEGHENY	USA	Minority Health and Health Disparities Research	000	1	8/30/2022	NEW	$632,932
2022	2022	MAGEE-WOMENS RESEARCH INSTITUTE AND FOUNDATION	3339 WARD ST	PITTSBURGH	PA	15213	ALLEGHENY	USA	Minority Health and Health Disparities Research	001	1	9/8/2022	NEW	$0
														Subtotal = $632,932

Grand Total All Awards = $2,884,331

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Eliminating racial disparities in severe maternal morbidity by addressing hypertension in the year after delivery

Award Number: R01MD017083

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/30/2022

PERIOD OF PERFORMANCE END DATE: 04/30/2027

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