Perceived Negative Treatment and Adolescent Substance Use: Understanding Moderating Mechanisms of Sleep and Neighborhood Environment in the ABCD Study - Modified Abstract Section Perceived negative treatment based on one’s social characteristics is a key factor contributing to mental and physical health disparities. Yet, the impact of perceived negative treatment on behavioral health outcomes such as substance use (SU) is less clear, particularly in early life (e.g. late childhood and early adolescence). By middle adolescence, SU initiation is set in motion triggering subsequent developmental trajectories. Investigating the onset of SU, starting in late childhood, is critical for mitigating its downstream health consequences. There is even less science focused on multilevel factors that alleviate associations between perceived negative treatment and SU. This project addresses these gaps in developmental and health disparities science by investigating multiple forms of perceived negative treatment and SU (self-report & hair sample metabolites) from late childhood to middle adolescence, and by investigating sleep (parent-report & actigraphy duration & quality) and neighborhood environment (deprivation, crime, noise, walkability from geocodes) as moderators of the health impact of perceived negative treatment. Both sleep and neighborhood environment can be targeted by evidence-based programming as levers of change to reduce the impact of perceived negative treatment on SU. The project draws from the on-going, national, longitudinal study of Adolescent Brain Cognitive Development (ABCD), the largest national study of its kind that follows 11,875 children (9-10 years old) through adolescence. The project examines three research aims. First, the study investigates concurrent and longitudinal linkages between perceived negative treatment and SU, from late childhood to early adolescence, disentangling whether perceived negative treatment is a contributing or a resulting factor of SU initiation and continuation. Second, the study investigates the extent to which the linkages between perceived negative treatment and SU are conditioned by young people’s sleep. Finally, the study investigates the moderating role of neighborhood environment in linking perceived negative treatment, sleep, and SU, from late childhood to middle adolescence. For all research aims, the proposed project also explores how the associations of perceived negative treatment, SU, sleep, and neighborhood environment change from late childhood to adolescence, by testing multiple development-related differences (i.e., by data collection wave, developmental stage, age, grade level). Findings will elucidate critical developmental periods when interventions are most effective in helping young people facing disparities due to their various social characteristics navigate the negative health consequences of adverse social experiences. Essentially, this project will provide critical insights for youth SU programs including who is most at risk, what to target, and when to intervene.
