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Epigenomic mechanisms of risk and resilience: The role of parenting

Award Number: R01MD015401
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/25/2020
PERIOD OF PERFORMANCE END DATE: 02/28/2026

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Epigenomic mechanisms of risk and resilience: The role of parenting - Project Summary Hispanic youth are nearly three times more likely to be at high risk for developmental, behavioral, or social delays compared to white non-Hispanic children. Contributing to this risk disparity is disproportionate rates of Hispanic children living in poverty and heightened risk for exposure to early-life environmental adversity, all of which confers substantial risk for the development of psychopathology and a lifelong risk for chronic diseases. A critical process by which disproportionate experiences of early adversity might influence risk for the development of later psychopathology is through the biological embedding of adversity exposure via epigenetic changes in genes involved in neuroendocrine and inflammatory responses to stress response. Despite promise and progress of social epigenomic research on risk processes, a significant limitation of the extant literature is that a basic understanding of how biological embedding of adversity can be prevented or reversed has yet to be achieved, with little knowledge of the role of protective factors that impact these developmental trajectories. In fact, prior work in humans has been almost exclusively cross-sectional and focused on detrimental environmental impacts, greatly constraining our understanding of epigenomic processes over time and its positive malleability to interventions. The proposed research will leverage an on-going NIH-funded R01 (#HD084497) to evaluate, via a randomized controlled trial of a home-based behavioral parent training intervention, how changing social context (i.e., dysfunctional parenting) alters the epigenome among at-risk Hispanic preschoolers and potentially establishes a biological foundation that promotes resiliency and potentially ameliorates the biological embedding of adversity. In the current proposal, we propose to use a balanced analytical approach that includes (1) a hypothesis-driven pathway analyses for genes involved in neuroendocrine and inflammatory responses to stress, (2) a targeted design that pulls sites previously identified in well-powered EWAS studies to create poly-epigenetic risk scores, and (3) a hypothesis-free epigenome-wide association study. In addition to examining trajectories of change in child DNA methylation, we will determine if exposure to a protective factor (positive parenting) buffers the impact of adversity on biomarkers of accelerated aging during a sensitive developmental stage. Lastly, we will explore epigenomic biosignatures of response to early intervention based on both child and parent DNA methylation. For all aims, we will use a multi-informant, multi-method design that includes observations of parenting, task-based measures of child self-regulation, standardized assessments of child developmental and clinical outcomes, independent clinical evaluators, and both child and parent DNA methylation. This research will facilitate the application of precision medicine and prevention approaches by identifying epigenomic biomarkers of early intervention response patterns that will allow for innovative strategies in risk identification and personalized prevention, together resulting in a new understanding of effective approaches to reducing health disparities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF RHODE ISLAND	75 LOWER COLLEGE RD RM 103	KINGSTON	RI	02881	WASHINGTON	USA	Minority Health and Health Disparities Research	000	7	1/15/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $429,697 )
2024	2024	UNIVERSITY OF RHODE ISLAND	75 LOWER COLLEGE RD RM 103	KINGSTON	RI	02881	WASHINGTON	USA	Minority Health and Health Disparities Research	007	7	5/30/2024	NON-COMPETING CONTINUATION	$35,840
2024	2024	UNIVERSITY OF RHODE ISLAND	75 LOWER COLLEGE RD RM 103	KINGSTON	RI	02881	WASHINGTON	USA	Minority Health and Health Disparities Research	006	7	2/20/2024	NON-COMPETING CONTINUATION	$322,567
2024	2023	UNIVERSITY OF RHODE ISLAND	75 LOWER COLLEGE RD RM 103	KINGSTON	RI	02881	WASHINGTON	USA	Minority Health and Health Disparities Research	005	6	1/18/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$168,474
2024	2023	BRADLEY EMMA PENDLETON HOSPITAL	1011 VETERANS MEMORIAL PKWY	RIVERSIDE	RI	02915	PROVIDENCE	USA	Minority Health and Health Disparities Research	000	5	11/1/2023	NON-COMPETING CONTINUATION	-$239,482
2024	2023	EMMA PENDLETON BRADLEY HOSPITAL	1011 VETERANS MEMORIAL PKWY	RIVERSIDE	RI	02915	PROVIDENCE	USA	Minority Health and Health Disparities Research	004	5	1/18/2024	NON-COMPETING CONTINUATION	-$87,299
2024	2023	UNIVERSITY OF RHODE ISLAND	75 LOWER COLLEGE RD RM 103	KINGSTON	RI	02881	WASHINGTON	USA	Minority Health and Health Disparities Research	002	6	11/12/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2024	2023	UNIVERSITY OF RHODE ISLAND	75 LOWER COLLEGE RD RM 103	KINGSTON	RI	02881	WASHINGTON	USA	Minority Health and Health Disparities Research	001	6	11/1/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$310,772
2024	2022	EMMA PENDLETON BRADLEY HOSPITAL	1011 VETERANS MEMORIAL PKWY	RIVERSIDE	RI	02915	PROVIDENCE	USA	Minority Health and Health Disparities Research	003	4	1/18/2024	NON-COMPETING CONTINUATION	-$81,175
														Subtotal = $429,697

Issue Date FY: 2023 ( Subtotal = $326,781 )
2023	2023	BRADLEY EMMA PENDLETON HOSPITAL	1011 VETERANS MEMORIAL PKWY	RIVERSIDE	RI	02915	PROVIDENCE	USA	Minority Health and Health Disparities Research	002	5	1/24/2023	NON-COMPETING CONTINUATION	$326,781
2023	2022	BRADLEY EMMA PENDLETON HOSPITAL	1011 VETERANS MEMORIAL PKWY	RIVERSIDE	RI	02915	PROVIDENCE	USA	Minority Health and Health Disparities Research	001	4	10/24/2022	NON-COMPETING CONTINUATION	$30,715
2023	2021	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Minority Health and Health Disparities Research	000	2	10/24/2022	NON-COMPETING CONTINUATION	-$30,715
														Subtotal = $326,781

Issue Date FY: 2022 ( Subtotal = $311,358 )
2022	2022	EMMA PENDLETON BRADLEY HOSPITAL	1011 VETERANS MEMORIAL PKWY	RIVERSIDE	RI	02915	PROVIDENCE	USA	Minority Health and Health Disparities Research	002	4	1/27/2022	NON-COMPETING CONTINUATION	$278,185
2022	2022	BRADLEY EMMA PENDLETON HOSPITAL	1011 VETERANS MEMORIAL PKWY	RIVERSIDE	RI	02915	PROVIDENCE	USA	Minority Health and Health Disparities Research	004	4	5/3/2022	NON-COMPETING CONTINUATION	$33,173
2022	2022	EMMA PENDLETON BRADLEY HOSPITAL	1011 VETERANS MEMORIAL PKWY	RIVERSIDE	RI	02915	PROVIDENCE	USA	Minority Health and Health Disparities Research	003	4	2/15/2022	NON-COMPETING CONTINUATION	$0
2022	2021	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Minority Health and Health Disparities Research	000	2	12/14/2021	NON-COMPETING CONTINUATION	-$348,070
2022	2021	EMMA PENDLETON BRADLEY HOSPITAL	1011 VETERANS MEMORIAL PKWY	RIVERSIDE	RI	02915	PROVIDENCE	USA	Minority Health and Health Disparities Research	001	3	12/14/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$348,070
														Subtotal = $311,358

Issue Date FY: 2021 ( Subtotal = $463,461 )
2021	2021	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Minority Health and Health Disparities Research	001	2	3/15/2021	NON-COMPETING CONTINUATION	$46,347
2021	2021	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Minority Health and Health Disparities Research	002	2	7/13/2021	NON-COMPETING CONTINUATION	$0
2021	2021	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Minority Health and Health Disparities Research	000	2	2/22/2021	NON-COMPETING CONTINUATION	$417,114
														Subtotal = $463,461

Issue Date FY: 2020 ( Subtotal = $473,525 )
2020	2020	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Minority Health and Health Disparities Research	001	1	7/27/2020	NEW	$0
2020	2020	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Minority Health and Health Disparities Research	000	1	7/25/2020	NEW	$473,525
														Subtotal = $473,525

Grand Total All Awards = $2,004,822

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Epigenomic mechanisms of risk and resilience: The role of parenting

Award Number: R01MD015401

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/25/2020

PERIOD OF PERFORMANCE END DATE: 02/28/2026

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