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Simulation Modeling to Understand and Address HIV Disparities in Racial, Ethnic, and Sexual Minority Populations

Award Number: R01MD014703
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Racial, ethnic, and sexual minority populations are disproportionately impacted by infectious disease, particularly HIV. Individuals at the intersection of multiple of these marginalized identities are even more likely to be impacted by HIV – especially Black and Hispanic men who have sex with men. While there is growing evidence that the day-to-day life of racial and sexual minorities differs from majority populations, there is a limited understanding of how differences in neighborhoods, differences in places where time is spent, and differences in the kinds of people connected with may impact disease spread and fuel disparities. Moreover, there is even less comprehensive understanding of how public health strategies could be refined to specifically reduce health disparities. Simulation models that accurately replicate population dynamics by simulating the movement and interaction of millions of individuals allow researchers a toolbox to understand the underlying dynamics of disease transmission and identify potential targets for intervention. This project joins two complementary teams of researchers in Chicago to build chiSTIG, a simulation model specifically derived to understand the social contextual dynamics which lead to disparities in HIV. The first team, at Northwestern University, have been funded by the NIH to capture rich data on the social systems and physical spaces inhabited by racial and sexual minorities, and have utilized these data to understand how the social and sexual isolation of young Black men who have sex with men (BMSM) in Chicago drives disparities in HIV. The second team, at the University of Chicago/Argonne National Laboratory, have built chiSIM, an extraordinarily powerful agent-based modeling (ABM) framework that simulates the interaction of 2.9 million Chicagoans across 1.2 million geo-located places to understand disease outbreaks and guide intervention development. chiSIM is a flexible system that has been used to understand prevention strategies for a number of infectious diseases. We propose to utilize several existing rich empirical datasets to build a chiSIM-derived model, chiSTIG, so that it might serve as a counterfactual laboratory able to test competing hypotheses regarding the etiology of infectious disease inequities in HIV for sexual minorities, specifically Black and Hispanic MSM, and potential routes for intervention. Specifically, the framework will be extended through the integration of detailed data on the physical and online third places utilized by and the social and sexual interactions of racially diverse MSM in Chicago.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $400,960 )
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	002	4	9/24/2023	NON-COMPETING CONTINUATION	$0
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	000	4	12/4/2022	NON-COMPETING CONTINUATION	$360,864
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	001	4	2/6/2023	NON-COMPETING CONTINUATION	$40,096
														Subtotal = $400,960

Issue Date FY: 2022 ( Subtotal = $400,801 )
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	001	3	4/28/2022	NON-COMPETING CONTINUATION	$40,081
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	000	3	12/23/2021	NON-COMPETING CONTINUATION	$360,720
														Subtotal = $400,801

Issue Date FY: 2021 ( Subtotal = $400,468 )
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	000	2	12/16/2020	NON-COMPETING CONTINUATION	$360,420
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	001	2	3/15/2021	NON-COMPETING CONTINUATION	$40,048
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	002	2	5/17/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $400,468

Issue Date FY: 2020 ( Subtotal = $412,990 )
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Minority Health and Health Disparities Research	000	1	5/2/2020	NEW	$412,990
														Subtotal = $412,990

Grand Total All Awards = $1,615,219

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Simulation Modeling to Understand and Address HIV Disparities in Racial, Ethnic, and Sexual Minority Populations

Award Number: R01MD014703

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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