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AMERICAN INDIAN CHronic disEase RIsk and Sleep Health (AI-CHERISH)

Award Number: R01MD014035
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/13/2019
PERIOD OF PERFORMANCE END DATE: 01/31/2026

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AMERICAN INDIAN CHronic disEase RIsk and Sleep Health (AI-CHERISH) - ABSTRACT: Both comparative and single-race studies suggest that sleep disorders are at least as prevalent among American Indians and Alaska Natives (AI/ANs) as they are in the all-races population. Sleep problems are known to be important contributors to chronic disease and early mortality in all populations, while effective treatment of sleep disorders improves the management of diverse health conditions. We propose to conduct an innovative mixed-methods study – American Indian CHronic disEase RIsk and Sleep Health (AI- CHERISH) – to assess the relationship between CVD and metabolic risk and sleep health in the context of Native culture. During the first 2 project years, we will conduct 5 focus groups (15 groups total; 12 participants each) and 2 rounds of semi-structured interviews with 5 key informants (30 interviews total). The resulting qualitative data will inform the development of a patient-reported outcome measure (PROM) of sleep health, to augment established measures accounting for factors specific to Native communities, and culturally-grounded, complementary guidelines for improving sleep. In the quantitative portion of this work, we will implement the largest epidemiologic study of sleep health to date with an AI/AN sample to assess the population prevalence of sleep deficiencies and their association with specific CVD risk factors. Participants in the epidemiologic study were previously enrolled in the Strong Heart Family Study (SHFS). For the epidemiologic study, we will recruit 250 AI participants aged 30–50 years from each geographic region (N=750) and collect sleep data from each participant during 2 study visits in a single 9-month period, with a visit during the months with the longest and shortest daylight exposure (May–July and November–January). For 7 days before each data collection visit, participants will wear wrist actigraphs to measure sleeping and waking activities, and will keep a diary to document waking activities as well as sleep duration, consolidation, and timing. When they return the actigraphs, they will complete 4 validated self-report instruments: the Pittsburgh Sleep Quality Index, the Epworth Sleepiness Scale, the Sleep Hygiene Index, the Insomnia Severity Index, and the STOP-Bang questionnaire. They will also provide data on sociodemographics and on CVD risk factors (blood lipids, hemoglobin A1C, blood pressure, BMI) known to be influenced by sleep. Our Specific Aims are to: 1) Develop a culturally appropriate PROM of sleep health based on the local context affecting sleep at each study site by using focus groups. 2) In key informant interviews, evaluate existing guidelines and elucidate complementary culturally-grounded guidelines for improving sleep health at each study site to augment existing guidelines for AI communities. 3) Estimate the prevalence and nature of sleep deficiencies in a sample of 750 AI adults at 3 study sites by analyzing objective data from actigraphy and subjective data from sleep/wake diaries and standardized sleep instruments collected at 2 time points during a 9-month period. 4) Assess the cross-sectional associations of poor sleep health, as defined by our objective and subjective sleep measures, with CVD and metabolic risk factors.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Minority Health and Health Disparities Research	001	5	4/3/2025	NON-COMPETING CONTINUATION	$0
2025	2023	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Minority Health and Health Disparities Research	000	5	12/19/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $513,712 )
2023	2023	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Minority Health and Health Disparities Research	000	5	1/22/2023	NON-COMPETING CONTINUATION	$528,444
2023	2023	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Minority Health and Health Disparities Research	002	5	2/16/2023	NON-COMPETING CONTINUATION	-$14,732
2023	2022	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Minority Health and Health Disparities Research	001	4	2/16/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2020	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Minority Health and Health Disparities Research	003	2	4/7/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $513,712

Issue Date FY: 2022 ( Subtotal = $679,015 )
2022	2022	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Minority Health and Health Disparities Research	006	4	6/6/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2022	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Minority Health and Health Disparities Research	005	4	5/31/2022	SUPPLEMENT FOR EXPANSION	$10,360
2022	2022	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Minority Health and Health Disparities Research	002	4	1/24/2022	NON-COMPETING CONTINUATION	$517,874
2022	2022	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Minority Health and Health Disparities Research	003	4	1/28/2022	SUPPLEMENT FOR EXPANSION	$93,240
2022	2022	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Minority Health and Health Disparities Research	004	4	5/3/2022	NON-COMPETING CONTINUATION	$57,541
2022	2021	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Minority Health and Health Disparities Research	000	3	10/15/2021	SUPPLEMENT FOR EXPANSION	$0
2022	2021	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Minority Health and Health Disparities Research	001	3	11/7/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $679,015

Issue Date FY: 2021 ( Subtotal = $705,081 )
2021	2021	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Minority Health and Health Disparities Research	000	3	4/5/2021	NON-COMPETING CONTINUATION	$581,028
2021	2021	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Minority Health and Health Disparities Research	001	3	8/11/2021	SUPPLEMENT FOR EXPANSION	$124,053
														Subtotal = $705,081

Issue Date FY: 2020 ( Subtotal = $588,671 )
2020	2020	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Minority Health and Health Disparities Research	000	2	1/30/2020	NON-COMPETING CONTINUATION	$588,671
2020	2019	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Minority Health and Health Disparities Research	001	1	6/2/2020	NEW	$0
														Subtotal = $588,671

Issue Date FY: 2019 ( Subtotal = $589,661 )
2019	2019	WASHINGTON STATE UNIVERSITY	240 FRENCH ADMINISTRATION BLDG	PULLMAN	WA	99164	WHITMAN	USA	Minority Health and Health Disparities Research	000	1	5/13/2019	NEW	$589,661
														Subtotal = $589,661

Grand Total All Awards = $3,076,140

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AMERICAN INDIAN CHronic disEase RIsk and Sleep Health (AI-CHERISH)

Award Number: R01MD014035

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/13/2019

PERIOD OF PERFORMANCE END DATE: 01/31/2026

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