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The long-term effectiveness of and the disparities in access to treatments for obstructive sleep apnea: a study on the All of Us data

Award Number: R01MD013886
ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder that affects up to 38% of North Americans. OSA causes hypoxemia and oxidative stress that lead to increased risks of cardiovascular diseases, type 2 diabetes and various chronic conditions. It also contributes to health disparities as racial and ethnic minority groups are more likely to experience delay in diagnosis and treatment than non-Hispanic Whites, along with the fact that these minorities may have a higher prevalence of OSA. Treatments of OSA, including continuous positive airway pressure (CPAP) and upper airway surgery, are effective in relieving patients' hypopneic symptoms and therefore also thought to reduce the risks of these morbidities. However, previous studies on CPAP did not show significant impact on these outcomes and findings remain inconclusive due to poor compliance of the participants. In addition, literature regarding the long-term benefits of upper airway surgery is extremely lacking. It is also important to characterize OSA patients who will have higher risks of long-term morbidities. The proposed project will leverage the big data from the National Institutes of Health All of Us Research Program to study the long-term effects of CPAP and surgery on downstream morbidities, and to identify critical predictors for OSA patients who are at risk of these outcomes. In addition, the project aims to evaluate the racial and ethnical disparities in access to OSA treatment, and the mediation effect of socioeconomic and healthcare factors. The project, if successfully carried out, should have important scientific and social implications by providing a better understanding of the benefit of each treatment, facilitating personalized medicine, and reducing health disparities in OSA.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	NEW YORK UNIVERSITY	101 MINEOLA BLVD	MINEOLA	NY	11501	NASSAU	USA	Minority Health and Health Disparities Research	002	5	2/7/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2022	NEW YORK UNIVERSITY	101 MINEOLA BLVD	MINEOLA	NY	11501	NASSAU	USA	Minority Health and Health Disparities Research	000	5	2/7/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2024	2022	NEW YORK UNIVERSITY	101 MINEOLA BLVD	MINEOLA	NY	11501	NASSAU	USA	Minority Health and Health Disparities Research	001	5	2/7/2024	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $843,333 )
2022	2022	NEW YORK UNIVERSITY	101 MINEOLA BLVD	MINEOLA	NY	11501	NASSAU	USA	Minority Health and Health Disparities Research	003	5	5/18/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$332,237
2022	2022	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Minority Health and Health Disparities Research	000	4	2/7/2022	NON-COMPETING CONTINUATION	$345,875
2022	2022	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Minority Health and Health Disparities Research	002	4	5/18/2022	NON-COMPETING CONTINUATION	-$384,305
2022	2022	NEW YORK UNIVERSITY	101 MINEOLA BLVD	MINEOLA	NY	11501	NASSAU	USA	Minority Health and Health Disparities Research	010	5	8/2/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1
2022	2022	NEW YORK UNIVERSITY	101 MINEOLA BLVD	MINEOLA	NY	11501	NASSAU	USA	Minority Health and Health Disparities Research	011	5	9/6/2022	SUPPLEMENT FOR EXPANSION	$146,720
2022	2022	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Minority Health and Health Disparities Research	007	4	7/20/2022	NON-COMPETING CONTINUATION	-$1
2022	2022	NEW YORK UNIVERSITY	101 MINEOLA BLVD	MINEOLA	NY	11501	NASSAU	USA	Minority Health and Health Disparities Research	004	5	6/12/2022	SUPPLEMENT FOR EXPANSION	$364,375
2022	2022	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Minority Health and Health Disparities Research	001	4	4/27/2022	NON-COMPETING CONTINUATION	$38,431
2022	2022	NEW YORK UNIVERSITY	101 MINEOLA BLVD	MINEOLA	NY	11501	NASSAU	USA	Minority Health and Health Disparities Research	008	5	7/20/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$426,273
2022	2022	NEW YORK UNIVERSITY	101 MINEOLA BLVD	MINEOLA	NY	11501	NASSAU	USA	Minority Health and Health Disparities Research	009	5	8/2/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$1
2022	2021	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Minority Health and Health Disparities Research	005	3	7/20/2022	NON-COMPETING CONTINUATION	-$384,237
2022	2020	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Minority Health and Health Disparities Research	006	2	7/20/2022	SUPPLEMENT FOR EXPANSION	-$42,035
														Subtotal = $843,333

Issue Date FY: 2021 ( Subtotal = $384,237 )
2021	2021	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Minority Health and Health Disparities Research	001	3	3/12/2021	NON-COMPETING CONTINUATION	$38,424
2021	2021	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Minority Health and Health Disparities Research	000	3	2/3/2021	NON-COMPETING CONTINUATION	$345,813
														Subtotal = $384,237

Issue Date FY: 2020 ( Subtotal = $768,104 )
2020	2020	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Minority Health and Health Disparities Research	001	2	1/30/2020	NON-COMPETING CONTINUATION	$384,088
2020	2020	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Minority Health and Health Disparities Research	002	2	6/29/2020	SUPPLEMENT FOR EXPANSION	$384,016
2020	2019	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Minority Health and Health Disparities Research	000	1	1/8/2020	NEW	$0
														Subtotal = $768,104

Issue Date FY: 2019 ( Subtotal = $421,443 )
2019	2019	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Minority Health and Health Disparities Research	001	1	7/12/2019	NEW	$0
2019	2019	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Minority Health and Health Disparities Research	000	1	7/11/2019	NEW	$421,443
														Subtotal = $421,443

Grand Total All Awards = $2,417,117

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The long-term effectiveness of and the disparities in access to treatments for obstructive sleep apnea: a study on the All of Us data

Award Number: R01MD013886

ORGANIZATION: NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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