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Bioinformatics of metastatic migration histories

Award Number: R01LM013385
ORGANIZATION: NATIONAL LIBRARY OF MEDICINE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/06/2020
PERIOD OF PERFORMANCE END DATE: 02/28/2025

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Bioinformatics of metastatic migration histories - Project Summary/Abstract Cancer causes more than 500,000 deaths a year in the United States, with more than 90% of the morbidity and mortality attributed to metastases. Metastasis is the spread of cancerous clones of cells across a body, whose dispersal routes are not medically detected or visible until later stages of cancer development. These migratory routes are critical to our understanding of the processes that influence tumor diversity in patients as well as aggressiveness, resistance, and escape of tumors from therapy. Comparative analysis of the extensive genetic heterogeneity present in tumors can be used to map the dynamic history of cancer cell migration over time and space. We propose to develop new methods for inferring cancer cell migrations accurately. Our new approaches will employ principles of Bayesian molecular phylogenetics and patterns of mutational signatures in cancer cell genomes for the first time to produce accurate maps of cell migration among tumor sites. We will also develop new methods for detecting mutational signatures. These will overcome many limitations of the current methods for datasets containing a small number of mutations, a situation commonly encountered in single- patient clone phylogenies. Our methodological developments will be complemented by the distribution of a library of functions containing our new and advanced approaches for high-throughput and in-depth analysis of metastatic tumor genomic data. Overall, the proposed software and research developments will lead to advances in cancer, bioinformatics, functional genomics, and data science. New software and its source code will be made available free of charge for all uses, including research, education, and training.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1805 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Medical Library Assistance	000	4	6/25/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $339,789 )
2023	2023	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Medical Library Assistance	000	4	2/1/2023	NON-COMPETING CONTINUATION	$339,789
														Subtotal = $339,789

Issue Date FY: 2022 ( Subtotal = $339,702 )
2022	2022	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Medical Library Assistance	000	3	1/31/2022	NON-COMPETING CONTINUATION	$339,702
														Subtotal = $339,702

Issue Date FY: 2021 ( Subtotal = $339,618 )
2021	2021	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Medical Library Assistance	002	2	4/27/2021	NON-COMPETING CONTINUATION	$16,982
2021	2021	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Medical Library Assistance	001	2	2/22/2021	NON-COMPETING CONTINUATION	$16,981
2021	2021	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Medical Library Assistance	000	2	1/29/2021	NON-COMPETING CONTINUATION	$305,655
														Subtotal = $339,618

Issue Date FY: 2020 ( Subtotal = $354,161 )
2020	2020	TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	1801 N BROAD ST	PHILADELPHIA	PA	19122	PHILADELPHIA	USA	Medical Library Assistance	000	1	5/6/2020	NEW	$354,161
														Subtotal = $354,161

Grand Total All Awards = $1,373,270

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Bioinformatics of metastatic migration histories

Award Number: R01LM013385

ORGANIZATION: NATIONAL LIBRARY OF MEDICINE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/06/2020

PERIOD OF PERFORMANCE END DATE: 02/28/2025

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