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Characterizing COVID-19 Patients through a Community Health Information Exchange and EHR databases

Award Number: R01LM012605
ORGANIZATION: NATIONAL LIBRARY OF MEDICINE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/01/2020
PERIOD OF PERFORMANCE END DATE: 04/30/2023

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Characterizing COVID-19 Patients through a Community Health Information Exchange and EHR databases - Project Summary/Abstract The COVID-19 pandemic is a significant public health problem that will require novel approaches for management and intervention. Knowledge of the disease’s transmission, symptomatology, clinical course, treatment and outcomes is rapidly evolving based on many sources. An important source for advancing this knowledge are data from electronic health records (EHR) and health information exchanges (HIE) because they can provide a real-time, unvarnished view of the disease. However, the initially “invisible” nature of the disease makes clear that clinicians and public health personnel were at a significant disadvantage in discovering and quantifying the pandemic. There is an urgent need to learn rapidly from EHR and other data to improve discovery and monitoring of patients infected by the coronavirus. The evolving dynamic and understanding of the incidence and course of COVID-19 requires that we develop new methods for discovery from data. The long-term goal of our research is to develop collaborative filtering algorithms to facilitate access to and analysis of clinical data. The goal of this application is to characterize COVID-19 patients through data in a community HIE, specifically the Indiana Network for Patient Care (INPC) within Indiana’s HIE (IHIE), and understand how that characterization differs from that within the EHRs of individual health systems. Understanding how COVID-19 patients are represented in HIEs and EHRs will build an important foundation for downstream computational activities, such as real-time discovery, public health surveillance, intervention management and contact tracing. The two specific aims of this project are to (1) extract a cohort of patients suffering from COVID-19 and similar diseases from IHIE and (2) characterize patients according to several dimensions, such as demographics, signs and symptoms, and disease course using both the INPC as well as separate EHR data sets. The data, going back to 1/1/2015, will be extracted from the INPC, and the clinical data warehouses at IU Health and Eskenazi Health, two of our major health system partners. As of this writing, 230,749 individuals in Indiana (3.4 percent of the population of 6.73m) have been tested for the coronavirus, of whom 32,078 (13.9 percent) have tested positive. We will apply computational phenotyping approaches using both HIE and individual EHR data in order to help us evaluate to what degree data from individual EHRs can help approximate characterizations based on HIE data. This proposal is significant because it will help us understand how HIE and EHR data can be used to characterize both COVID-19 and non-COVID-19 patients. It is innovative because it leverages multiple computational phenotyping methods on both individual organizations’ EHR, as well as HIE, data to generate a comprehensive characterization of COVID-19 and non-COVID-19 patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$4,134 )
2023	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Medical Library Assistance	001	3	9/14/2023	SUPPLEMENT FOR EXPANSION	-$4,134
2023	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Medical Library Assistance	000	3	9/14/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = -$4,134

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Medical Library Assistance	001	3	4/28/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Medical Library Assistance	000	3	4/27/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Medical Library Assistance	001	3	4/16/2021	SUPPLEMENT FOR EXPANSION	$0
2021	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Medical Library Assistance	000	3	4/16/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $616,638 )
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Medical Library Assistance	002	3	6/30/2020	SUPPLEMENT FOR EXPANSION	$74,999
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Medical Library Assistance	001	3	5/20/2020	NON-COMPETING CONTINUATION	$27,083
2020	2020	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Medical Library Assistance	000	3	4/17/2020	NON-COMPETING CONTINUATION	$514,556
														Subtotal = $616,638

Issue Date FY: 2019 ( Subtotal = $533,290 )
2019	2019	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Medical Library Assistance	000	2	4/29/2019	NON-COMPETING CONTINUATION	$533,290
														Subtotal = $533,290

Issue Date FY: 2018 ( Subtotal = $536,672 )
2018	2018	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Medical Library Assistance	000	1	5/31/2018	NEW	$536,672
														Subtotal = $536,672

Grand Total All Awards = $1,682,466

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Characterizing COVID-19 Patients through a Community Health Information Exchange and EHR databases

Award Number: R01LM012605

ORGANIZATION: NATIONAL LIBRARY OF MEDICINE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/01/2020

PERIOD OF PERFORMANCE END DATE: 04/30/2023

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