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Identifying Optimal Pain Management for Elders

Award Number: R01HS027434
ORGANIZATION: AGENCY FOR HEALTH CARE RESEARCH AND QUALITY
OPDIV: AHRQ
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2021
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Identifying Optimal Pain Management for Elders - ABSTRACT Surgery is common and appropriate postoperative pain management is critical as poor management can impair recovery and lead to adverse events, including prolonged opioid use and transition to chronic pain. Additional specific risks in elder surgical patients include delirium and falls. Currently prejudice rather than evidence guides the complex problem of elder perioperative pain management. Given the gravity of the US opioid epidemic, policy makers are quickly establishing rules and regulations for opioid prescribing. These policies are blanket regulations that neglect emerging evidence regarding the need for differential opioid prescriptions based on clinical and patient factors, particularly in elders. Currently, there lacks tools to identify elders at high risk for adverse pain outcomes. Such tools are needed to provide critical evidence on pain management to stakeholders and move the field away from pain treatment for the ‘average’ elder patient to pain treatment for an individual. In this grant, we propose an innovative approach to advance the systematic analysis of postoperative pain in elders. Our approach will develop scalable, open source risk stratification tools for adverse pain outcomes in elders. We will accomplish this work in three aims. First, we will develop clinical phenotypes to identify and extract key discriminating features necessary to assess postoperative pain using EHRs. Next, we will develop pain risk stratification models using machine learning, including deep learning, methods and tools based on phenotypes developed in Aim 1. Finally, we will validate our models externally at the VA and disseminate our work through open source libraries and public websites. This project will deliver validated risk-stratification tools derived from real world evidence to identify elder patients at high risk for adverse pain outcomes following surgery, which can potentially reduce prescribed opioids circulating in the community– a key to curbing the opioid epidemic.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $356,001 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research on Healthcare Costs, Quality and Outcomes	000	5	3/24/2025	NON-COMPETING CONTINUATION	$356,001
														Subtotal = $356,001

Issue Date FY: 2024 ( Subtotal = $365,434 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research on Healthcare Costs, Quality and Outcomes	000	4	3/15/2024	NON-COMPETING CONTINUATION	$365,434
														Subtotal = $365,434

Issue Date FY: 2023 ( Subtotal = $373,993 )
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research on Healthcare Costs, Quality and Outcomes	000	3	3/23/2023	NON-COMPETING CONTINUATION	$373,993
														Subtotal = $373,993

Issue Date FY: 2022 ( Subtotal = $384,421 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research on Healthcare Costs, Quality and Outcomes	000	2	3/30/2022	NON-COMPETING CONTINUATION	$384,421
														Subtotal = $384,421

Issue Date FY: 2021 ( Subtotal = $393,732 )
2021	2021	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Research on Healthcare Costs, Quality and Outcomes	000	1	3/22/2021	NEW	$393,732
														Subtotal = $393,732

Grand Total All Awards = $1,873,581

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Identifying Optimal Pain Management for Elders

Award Number: R01HS027434

ORGANIZATION: AGENCY FOR HEALTH CARE RESEARCH AND QUALITY

OPDIV: AHRQ

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2021

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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