Saturday, October 5, 2024 10/5/2024

A Trial to Explore the Benefits of Antimicrobial Self-Sanitizing Surfaces on Bio-Burden Levels and Healthcare-Acquired Infections.

Award Number: R01HS025598
ORGANIZATION: AGENCY FOR HEALTH CARE RESEARCH AND QUALITY
OPDIV: AHRQ
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Prevention of healthcare-acquired infections (HAIs) is a priority challenge. The exact degree to which hospital surfaces influence the transmission of HAIs is not well understood. Current cleaning procedures such as sanitation of surfaces in hospital rooms with dilute sodium hypochlorite (bleach) and the use of ultraviolet light, while efficacious in reducing surface contamination episodically, do not provide continuous antibacterial activity. Furthermore, due to inadequate manual cleaning, antibiotic-resistant pathogens, such as methicillin- resistant Staphylococcus aureus (MRSA) and Clostridium difficile (C. diff) can live on surfaces for several months. Copper has antimicrobial properties against important antibiotic-resistant pathogen. Implementing copper and copper alloys in surfaces has the promise of continuous microbial killing power in the background as adjunct to current effective (although intermittent) strategies. This implementation study will explore the benefit of converting high touch surfaces in patient rooms to a novel self-sanitizing copper oxide-impregnated solid surface (SSS-Cu) manufactured by EOSCu Surfaces LLC, Norfolk, Virginia. The SSS-Cu has a uniform distribution of 16%-20% copper oxide. SSS-Cu has proven to be 99.9% bactericidal within 2 hours in a laboratory setting, has been registered with the Environmental Protection Agency (EPA) as environmentally safe, and has been associated with a significant decline in HAIs in a prior study at the Sentara Leigh Hospital, Norfolk, Virginia. The specific aims of our proposed study are to (1) establish real world effectiveness of SSS-Cu in the prevention of bio-burden accumulation in occupied patient rooms; (2) establish the effect of SSS-Cu as an adjunct to standard disinfection protocols on HAI rates for patients admitted to the study hospital; and (3) determine the economic impact of the use of SSS-Cu in the hospital setting. A prospective pre-post study design is proposed to compare hospital surface bio-burden and HAI rates between patient room environments with and without SSS-Cu surfaces. With the installation of SSS-Cu in acute and critical care rooms, environmental bioburden will be compared before copper surface installation to after copper surface installation. Further additional samples will be taken at 18 months and 36 months to evaluate continued efficacy of copper over time. HAI rates among all patients admitted to the hospital for a three-year period prior to installation of SSS-Cu will be compared to HAI rates among all patients admitted to the hospital for a three-year period following the completion of installation of SSS-Cu in all acute and critical care rooms. The setting for this study is a 120-bed inpatient facility that is part of an integrated VA health care system in Temple, Texas. We expect that SSS-Cu materials will lower environmental bio-burden, lower HAI rates, and result in significant decreases in infection-associated inpatient healthcare expenditures when compared to standard, non-SSS-Cu hospital rooms.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	CENTRAL TEXAS VETERANS RESEARCH FOUNDATION	1901 VETERANS MEMORIAL DR	TEMPLE	TX	76504	BELL	USA	Research on Healthcare Costs, Quality and Outcomes	000	5	6/3/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $338,314 )
2023	2023	CENTRAL TEXAS VETERANS RESEARCH FOUNDATION	RESEARCH OFFICE (151N) 1901 S 1ST ST	TEMPLE	TX	76504	BELL	USA	Research on Healthcare Costs, Quality and Outcomes	000	5	3/29/2023	NON-COMPETING CONTINUATION	$338,314
														Subtotal = $338,314

Issue Date FY: 2022 ( Subtotal = $442,710 )
2022	2022	CENTRAL TEXAS VETERANS RESEARCH FOUNDATION	RESEARCH OFFICE (151N) 1901 S 1ST ST	TEMPLE	TX	76504	BELL	USA	Research on Healthcare Costs, Quality and Outcomes	000	4	3/18/2022	NON-COMPETING CONTINUATION	$442,710
														Subtotal = $442,710

Issue Date FY: 2021 ( Subtotal = $453,389 )
2021	2021	CENTRAL TEXAS VETERANS RESEARCH FOUNDATION	RESEARCH OFFICE (151N) 1901 S 1ST ST	TEMPLE	TX	76504	BELL	USA	Research on Healthcare Costs, Quality and Outcomes	000	3	3/9/2021	NON-COMPETING CONTINUATION	$453,389
														Subtotal = $453,389

Issue Date FY: 2020 ( Subtotal = $480,279 )
2020	2020	CENTRAL TEXAS VETERANS RESEARCH FOUNDATION	RESEARCH OFFICE (151N) 1901 S 1ST ST	TEMPLE	TX	76504	BELL	USA	Research on Healthcare Costs, Quality and Outcomes	000	2	3/25/2020	NON-COMPETING CONTINUATION	$480,279
														Subtotal = $480,279

Issue Date FY: 2019 ( Subtotal = $484,985 )
2019	2019	CENTRAL TEXAS VETERANS RESEARCH FOUNDATION	RESEARCH OFFICE (151N) 1901 S 1ST ST	TEMPLE	TX	76504	BELL	USA	Research on Healthcare Costs, Quality and Outcomes	000	1	5/24/2019	NEW	$484,985
														Subtotal = $484,985

Grand Total All Awards = $2,199,677

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A Trial to Explore the Benefits of Antimicrobial Self-Sanitizing Surfaces on Bio-Burden Levels and Healthcare-Acquired Infections.

Award Number: R01HS025598

ORGANIZATION: AGENCY FOR HEALTH CARE RESEARCH AND QUALITY

OPDIV: AHRQ

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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