Tuesday, August 19, 2025 8/19/2025

Focused Imaging as a Novel Diagnostic Strategy for Aortic Stenosis

Award Number: R01HL180937
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2025
PERIOD OF PERFORMANCE END DATE: 05/31/2030

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Focused Imaging as a Novel Diagnostic Strategy for Aortic Stenosis - Aortic stenosis (AS) is a valve condition that affects over 12.6 million adults and causes an estimated 102,700 deaths each year. Many patients with AS do not know about the diagnosis because it is difficult to diagnose with a stethoscope. It is estimated that there are over 560,000 undiagnosed cases of AS in the United States alone. When patients with symptomatic AS are not treated, 50% will die in 2 years. We have developed a method to automate the diagnosis of AS from cardiac ultrasound imaging using machine learning. This represents a new way to diagnose AS. In this proposal we will improve these networks to reliably identify severe AS patients that should be referred for evaluation. Additionally, we will train the networks to work with portable handheld ultrasound devices and we will study how to implement this tool in primary care offices to screen high risk patients. By developing and validating innovative machine learning (ML) methods for diagnosing AS we will establish tools to improve the identification and treatment of this life-threating condition.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $793,868 )
2025	2025	TUFTS MEDICAL CENTER PARENT, INC.	800 WASHINGTON ST	BOSTON	MA	02111	SUFFOLK	USA	Cardiovascular Diseases Research	001	1	8/8/2025	NEW	$1,975
2025	2025	TUFTS MEDICAL CENTER PARENT, INC.	800 WASHINGTON ST	BOSTON	MA	02111	SUFFOLK	USA	Cardiovascular Diseases Research	000	1	7/24/2025	NEW	$791,893
														Subtotal = $793,868

Grand Total All Awards = $793,868

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Focused Imaging as a Novel Diagnostic Strategy for Aortic Stenosis

Award Number: R01HL180937

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2025

PERIOD OF PERFORMANCE END DATE: 05/31/2030

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