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Understanding the Impact of Early Life Factors on Cardiometabolic Risk throughout the Life Course in a Large Population-based Cohort of Adolescents and Young Adults

Award Number: R01HL177516
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2025
PERIOD OF PERFORMANCE END DATE: 11/30/2028

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Understanding the Impact of Early Life Factors on Cardiometabolic Risk throughout the Life Course in a Large Population-based Cohort of Adolescents and Young Adults - Cardiometabolic conditions - such as hypertension, prediabetes, type 2 diabetes mellitus (T2D), dyslipidemia, and metabolic dysfunction-associated fatty liver disease (MAFLD) - are among the leading causes of morbidity and mortality among US adults but are now severely affecting younger generations. Cardiometabolic conditions that emerge among adolescents and young adults (AYA) often have a more aggressive clinical course and lead to greater complications than do adult-onset ones, making identification of individuals at elevated risk and targeted early prevention efforts for AYA critical. Adolescence and young adulthood are important developmental windows, in which emerging health risks may have lifelong implications for cardiovascular diseases. However, little is known about the epidemiology of cardiometabolic outcomes among AYA populations because existing studies in AYA are extremely limited due to a lack of population-based studies, small sample sizes, cross-sectional designs, and lack of objective measures of cardiometabolic outcomes beyond BMI. In addition, there is also pressing interest in identifying upstream risk factors, particularly early life factors, because human metabolic and endocrine systems are programmed early in life. Our long-term goal is to better understand the epidemiology of cardiometabolic outcomes among AYA, identifying groups at higher incidence and risk factors to inform early detection and design upstream intervention strategies. To fill extant knowledge gaps and inform future prevention strategies, we will conduct a large longitudinal cohort study based on a large cohort of over 5 million AYA members (aged 10 to 30) from Kaiser Permanente Northern California (KPNC), an integrated health care system with membership representative of the source population. We will use electronic health record data to link diagnosis, laboratory, and other clinical data to describe incidence and temporal trends of cardiometabolic outcomes among AYA, by demographic subgroup (e.g., sex, age) and BMI categories (Aim 1). We will also investigate how childhood and adolescent BMI trajectories influence cardiometabolic outcomes (Aim 2), knowledge that is lacking among AYA populations. Finally, using data from a sub-cohort (n>500,000) that was born at KPNC, we will identify prenatal and early factors associated with the cardiometabolic risks in AYA (Aim 3). Results will inform early targeted interventions aimed at lowering cardiometabolic risks throughout the life course.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $726,404 )
2026	2026	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Cardiovascular Diseases Research	000	2	4/7/2026	NON-COMPETING CONTINUATION	$726,404
														Subtotal = $726,404

Issue Date FY: 2025 ( Subtotal = $774,229 )
2025	2025	KAISER FOUNDATION HOSPITALS	1800 HARRISON ST FL 16	OAKLAND	CA	94612	ALAMEDA	USA	Cardiovascular Diseases Research	000	1	1/28/2025	NEW	$774,229
														Subtotal = $774,229

Grand Total All Awards = $1,500,633

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Understanding the Impact of Early Life Factors on Cardiometabolic Risk throughout the Life Course in a Large Population-based Cohort of Adolescents and Young Adults

Award Number: R01HL177516

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2025

PERIOD OF PERFORMANCE END DATE: 11/30/2028

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