Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

MicroRNA-mediated regulation of lymphatic growth and function

Award Number: R01HL177004
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/11/2026
PERIOD OF PERFORMANCE END DATE: 05/31/2030

Group Awards By:

View Award Description

MicroRNA-mediated regulation of lymphatic growth and function - PROJECT SUMMARY/ABSTRACT Lymphatic vessels are essential for maintaining tissue fluid balance, resolving inflammation, and supporting immune function, which are core processes relevant to cardiovascular and endothelial biology. Dysregulated lymphatic remodeling contributes to lymphedema, chronic inflammation, and cancer metastasis. However, the molecular mechanisms guiding lymphatic regeneration remain poorly defined. MicroRNAs (miRNAs) have emerged as key regulators of vascular function, but their roles in lymphatic endothelial cell (LEC) and vessel remodeling are not well understood. Our preliminary studies identify microRNA-204 (miR-204) as a conserved regulator of lymphangiogenesis that modulates LEC behavior, vessel growth, and structural recovery in vivo. We hypothesize that miR-204 promotes lymphatic regeneration by targeting gene networks critical for LEC fate and repair. We will test this hypothesis through three aims: (1) define the molecular mechanisms by which miR-204 regulates LEC identity and lymphangiogenesis; (2) investigate the role of miR-204 in lymphatic regeneration and edema recovery in vivo; and (3) assess the therapeutic potential of miR-204 delivery to enhance lymphatic repair and tissue recovery. This work integrates high-resolution imaging, lineage tracing, and miRNA-target discovery across zebrafish and mouse models. Findings will advance our understanding of lymphatic biology and support novel miRNA-based therapeutic strategies for vascular and lymphatic diseases.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $630,810 )
2026	2026	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Cardiovascular Diseases Research	000	1	9/11/2026	NEW	$630,810
														Subtotal = $630,810

Grand Total All Awards = $630,810

Top

All Categories

About

Search

Reports

Data Submission

Award Information

MicroRNA-mediated regulation of lymphatic growth and function

Award Number: R01HL177004

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/11/2026

PERIOD OF PERFORMANCE END DATE: 05/31/2030

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer