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Psycho-neuro-immune Mechanisms Linking Stigma and Discrimination to Carotid Plaque Formation in Persons living with HIV

Award Number: R01HL171416
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Abstract: Persons living with HIV experience constant stigma and discrimination. The project objective is to model the impact of the psychosocial experiences of stigma/discrimination on the complex interactions between multiple systems (neural, immune, and autonomic) that give rise to atherosclerotic processes in the context of treated chronic HIV-infection. This project assembles a multi-disciplinary team that will decipher the complexity of these interactions within a cohort of 150 racially, ethnically, and sexually diverse persons living with HIV (PWH) between the ages of 35-55 years that have stable anti-retroviral regimens and detectable viral loads without history of heart failure. The study aims to test two separate psycho-neuro-immune mediation models for experiences of social rejection and discrimination on carotid plaque formation measured through high resolution ultrasound. In the first model, using an interactive functional magnetic resonance imaging (fMRI) paradigm, change from pre- to post-task peripheral blood monocyte activation and expression of IL-6 will be tested as a mediator of the association between activation of threat-sensitive brain regions to social rejection and carotid plaque formation. In the second model, 7-day salivary IL-6 expression will be tested as mediator for the association of 7-day ecological momentary assessments (EMA) of everyday experiences of discrimination with carotid plaque formation. The reliability of these models of putative psycho-neuro-immune mechanisms in predicting carotid plaque burden will be assessed at baseline and 3-month follow-up. The study further aims to evaluate the potential mitigating role of the acetyl-cholinergic anti-inflammatory pathway on carotid plaque formation by testing whether an index of vagal-mediated heart rate variability (HRV) moderates of the associations of neural activation to rejection/discrimination (Aim 1) and naturalistic rejection/discrimination experiences (Aim 2) with change in proinflammatory cytokine expression. The long-term objectives of this study are two-fold. First, to elucidate the relationships amongst these biobehavioral determinants of carotid plaque formation in PWH, who are traditionally stigmatized and discriminated due to intersectionality of their race, ethnicity, gender, health, and sexual orientation status. The second long-term objective is to evaluate whether vagal-mediated HRV has a mitigating effect and thus serve as a target for future biobehavioral interventions for atherosclerotic CVD in PWH that have traditionally been socially marginalized, stigmatized and discriminated.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $681,316 )
2024	2024	UNIVERSITY OF MIAMI	1320 SOUTH DIXIE HIGHWAY STE 650	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Cardiovascular Diseases Research	000	2	7/30/2024	NON-COMPETING CONTINUATION	$681,316
														Subtotal = $681,316

Issue Date FY: 2023 ( Subtotal = $708,908 )
2023	2023	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 650	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Cardiovascular Diseases Research	000	1	8/15/2023	NEW	$708,908
														Subtotal = $708,908

Grand Total All Awards = $1,390,224

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Psycho-neuro-immune Mechanisms Linking Stigma and Discrimination to Carotid Plaque Formation in Persons living with HIV

Award Number: R01HL171416

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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