Friday, August 8, 2025 8/8/2025

Identification of Early HFpEF after Preeclampsia by Exercise Stress Testing

Award Number: R01HL170020
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/20/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2029

Group Awards By:

View Award Description

Identification of Early HFpEF after Preeclampsia by Exercise Stress Testing - ABSTRACT Pregnancy is a unique, early moment of cardiovascular stress in young women that may “unmask” cardiovascular disease (CVD) propensity. Preeclampsia (PreE)—characterized by new-onset hypertension and proteinuria—has been linked to left ventricular diastolic dysfunction that may persist for years post-partum, and an increased risk of developing heart failure with preserved ejection fraction (HFpEF) over the decade following pregnancy. It is unclear if PreE simply represents a failed stress test or directly contributes to the pathophysiology of future CVD. Women and minorities are traditionally understudied in HFpEF, despite their disproportionate risk. This is the first large prospective study to investigate the hypothesis that PreE leads to persistent functional, hemodynamic, structural and biochemical cardiovascular changes that mirror early HFpEF. By defining the echo, proteomic and hemodynamic risk profile for early HFpEF, this will afford the opportunity for future studies to mitigate disease through pharmacologic/lifestyle interventions in a targeted population. We hypothesize that persistent structural-functional myocardial alterations in women with PreE are linked to pre- and post-gravid cardiometabolic risk factors and functional capacity and select pathways of vascular and inflammatory stress central to HF risk. We will use perturbational hemodynamic studies to elaborate myocardial phentoypes defining of HFpEF in women with PreE. We address our central hypothesis in 3 Specific Aims (SA): SA1: To measure relation between post-partum subclinical LVDD and pregnancy-specific risk factors in 250 women with PreE and 250 normotensive women (25% Black) through rest and provocation echocardiographic imaging, SA2: To quantify the hemodynamic consequences of early persistent LVDD in women with PreE, SA3: To identify differences in cardiovascular pathways of vascular remodeling and inflammation and their association with subclinical myocardial dysfunction in women with PreE. For this study, we will leverage the infrastructure of our NIH funded multidisciplinary cardio-obstetrics clinical research team for recruitment, retention, and risk factor modification (U01HG013189, R21NR020857). A fundamental strength of this proposal is the ESI PI’s experience in recruiting and retaining women at this critical stage in CV development. Our targeted enrollment of Black women addresses clinical and investigative gaps in this population at high short and long-term CV risk following a preeclamptic pregnancy. Successful completion of these studies in a large group of women across race will define high-risk PreE-linked structural/functional changes to support risk stratification and future interventional studies at this critical moment in CVD development in women.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $863,354 )
2025	2025	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cardiovascular Diseases Research	000	2	7/29/2025	NON-COMPETING CONTINUATION	$863,354
														Subtotal = $863,354

Issue Date FY: 2024 ( Subtotal = $869,696 )
2024	2024	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cardiovascular Diseases Research	000	1	8/16/2024	NEW	$869,696
														Subtotal = $869,696

Grand Total All Awards = $1,733,050

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Identification of Early HFpEF after Preeclampsia by Exercise Stress Testing

Award Number: R01HL170020

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/20/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2029

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer