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Sleep and Cardiometabolic Subgroup Discovery and Risk Prediction in UnitedStates Adolescents and Young Adults: A Multi-Study Multi-Domain Analysis ofNHANES and NSRR

Award Number: R01HL168173
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2023
PERIOD OF PERFORMANCE END DATE: 01/31/2028

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Sleep and Cardiometabolic Subgroup Discovery and Risk Prediction in UnitedStates Adolescents and Young Adults: A Multi-Study Multi-Domain Analysis ofNHANES and NSRR - Project Summary/Abstract Cardiometabolic (CM) diseases including cardiovascular (CV) and metabolic diseases are the leading cause of preventable death in the United States and Worldwide. CM diseases are interconnected and positively associated with multi-domain Cardiometabolic Risk Factors (CMRFs) such as metabolic dysregulation, obesity, physical inactivity, poor nutrition, and other emerging factors (including and especially sleep disorders). CMRFs are highly and increasingly prevalent in adolescents and young adults, which foreshadows a future epidemic of incident CM diseases as they age. However, existing studies have primarily focused on the adult and senior population with little to no knowledge on the young population. CM data hold great promise to facilitate CM subgroup discovery for early risk stratification and precise prognosis. However, significant gaps exist in fully leveraging CM data. Gap I: Lack of inclusion of multi- domain CMRFs (especially sleep health). Gap II: Lack of “outcome-predictive” CM subgroups in early risk stratification. Gap III: Lack of “subgroup-specific” precise prognosis of “multi-dimensional” CM outcomes. Gap IV: Under-utilization of the rich but “incomplete” multi-domain CM data in NHANES and NSRR. We propose a multi-study multi-domain secondary analysis for CM subgroup discovery and risk prediction in U.S. adolescents (11-18) and young adults (19-39). The objective is to create 2 combined NHANES and NSRR datasets and examine multi-domain CMRFs including metabolic dysregulation, physical inactivity, poor nutrition, and multi- dimensional sleep measures for CM subgroup discovery and risk prediction in the large and diverse U.S. adolescent and young adult population of Hispanics/Latinos, African Americans, Caucasians, and Asian Americans. Aim 1. CM risk subgroup discovery at baseline for U.S. adolescents & young adults. (1.1) Develop a novel sparse Incomplete Multi-domain Mixed-typed Factor Mixture Model (IM2-FMM) for subgroup discovery from incomplete multi-domain mixed-typed CMRFs. (1.2) Apply IM2-FMM to identify, characterize, and evaluate CM subgroups in adolescents and young adults from incomplete multi-domain mixed-typed CMRFs at baseline including: (a) self-reported sleep measures in NHANES; (b) self-reported and objective sleep measures in NSRR. Aim 2. Subgroup-specific prediction of multi-dimensional longitudinal CM outcomes for young adults. (2.1) Develop a novel sparse Transfer Learning-based Generalized Multi-level Model (TL-GMM) to predict multi- dimensional longitudinal CM outcomes from clustered CMRFs at baseline. (2.2) Apply TL-GMM to young adults in NSRR to: (1) examine fixed effects and random effects of baseline CMRFs on CM outcomes; (2) provide subgroup-specific multi-dimensional prognosis of CM health from clustered CMRFs at baseline. Impact: Our study will generate novel insights into CM subgroup discovery to facilitate early and targeted interventions and help establish health promoting behaviors in adolescents and young adults, eventually improving CM health care in their transition to adulthood and reducing CM health disparities and costs as the young population ages.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $47,186 )
2026	2026	ARIZONA STATE UNIVERSITY	1475 N SCOTTSDALE RD STE 200	SCOTTSDALE	AZ	85257	MARICOPA	USA	National Center on Sleep Disorders Research	001	4	8/4/2026	NON-COMPETING CONTINUATION	$172
2026	2025	ARIZONA STATE UNIVERSITY	1475 N SCOTTSDALE RD STE 200	SCOTTSDALE	AZ	85257	MARICOPA	USA	National Center on Sleep Disorders Research	000	3	5/27/2026	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$47,014
														Subtotal = $47,186

Issue Date FY: 2025 ( Subtotal = $437,408 )
2025	2025	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	National Center on Sleep Disorders Research	001	3	3/1/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$437,408
2025	2024	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	National Center on Sleep Disorders Research	000	2	3/1/2025	NON-COMPETING CONTINUATION	$0
2025	2024	THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	National Center on Sleep Disorders Research	002	2	5/21/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $437,408

Issue Date FY: 2024 ( Subtotal = $482,427 )
2024	2024	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	National Center on Sleep Disorders Research	001	2	6/12/2024	NON-COMPETING CONTINUATION	$39,382
2024	2024	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	National Center on Sleep Disorders Research	000	2	1/29/2024	NON-COMPETING CONTINUATION	$443,045
														Subtotal = $482,427

Issue Date FY: 2023 ( Subtotal = $506,523 )
2023	2023	RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, THE	4400 VESTAL PKWY E	BINGHAMTON	NY	13902	BROOME	USA	National Center on Sleep Disorders Research	000	1	4/24/2023	NEW	$506,523
														Subtotal = $506,523

Grand Total All Awards = $1,473,544

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Sleep and Cardiometabolic Subgroup Discovery and Risk Prediction in UnitedStates Adolescents and Young Adults: A Multi-Study Multi-Domain Analysis ofNHANES and NSRR

Award Number: R01HL168173

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2023

PERIOD OF PERFORMANCE END DATE: 01/31/2028

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