Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

ImpleMEntation of a Digital-first care deLiverY model for heart failure in Uganda (MEDLY Uganda)

Award Number: R01HL166585
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2023
PERIOD OF PERFORMANCE END DATE: 07/31/2028

Group Awards By:

View Award Description

ImpleMEntation of a Digital-first care deLiverY model for heart failure in Uganda (MEDLY Uganda) - Heart failure (HF) is a clinical syndrome that causes multiple debilitating symptoms, premature mortality, and results in poor health-related quality of life. In sub-Saharan Africa, HF has a 34% 1-year mortality rate, the highest of any region globally. Major care gaps and health disparities exist throughout the continuum of HF care. Selfcare is an evidence-based intervention that can improve clinical and patient-reported outcomes in HF and holds particular promise in resource-limited settings in both the US and low- and middle-income countries (LMIC) because it shifts fundamental care tasks from providers and facilities to patients while empowering patients to better care for themselves. However, self-care is underutilized where providers lack knowledge, tools, and time to support patients in self-care. In Uganda, which has a high burden of hypertensive heart disease and is predominantly rural, this gap is especially salient given the limited number of cardiac specialists and facilities that are accessible to the population, making it an ideal setting to implement and evaluate self-care for HF. In this Type 2 hybrid study, we will implement two evidence-based interventions to improve self-care in HF at 6 Ugandan regional hospital outpatient departments and evaluate both implementation and clinical outcomes. All study aims are guided by the RE-AIM framework, involve mixed methods, and are designed to prioritize geographic and socioeconomic heterogeneity. First, we will assess the implementation and effectiveness of Medly Uganda to improve HF self-care in Uganda (Aim 1). To do this, we will conduct a stepped-wedge, cluster randomized trial that includes a control period, then a clinical package to support HF care (Core-HF), followed by the digital implementation strategy (Medly Uganda). The co-primary outcomes will be the Self-Care of HF Index (implementation) and the composite of mortality and HF hospitalization (effectiveness). In parallel to this, we will conduct a mixed methods process evaluation to inform iterative adjustments to the implementation processes (Sub-Aim 1.1) using a community-engaged approach to systematically collect qualitative and quantitative process data at pre-determined time points and make implementation adaptations (Learn-As-YouGo design). Next, we will evaluate fidelity and context of Medly Uganda with a focus on reach, adoption, and maintenance (Aim 2) using a deviance approach based on Medly Uganda meta data from patients and providers, focusing on how social determinants might impact implementation. We will also explore patient and provider impacts beyond HF, such as mental health and healthcare autonomy. Then, we will explore cost, cost effectiveness, and sustainability factors for Medly Uganda (Aim 3). This study will generate important insights to support implementation of innovative strategies to improve HF care in LMIC that will be directly applicable to Americans living with HF in resource-limited and rural parts of the United States. Using a reciprocal innovation approach with our ongoing U.S.-based work, we will foster bidirectional learning that will lead to better health outcomes across contexts.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $773,415 )
2026	2026	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	003	4	9/2/2026	SUPPLEMENT FOR EXPANSION	$31,590
2026	2026	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	004	4	9/2/2026	SUPPLEMENT FOR EXPANSION	$298,430
2026	2026	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	002	4	9/2/2026	SUPPLEMENT FOR EXPANSION	$235,673
2026	2026	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	001	4	8/24/2026	NON-COMPETING CONTINUATION	$207,722
2026	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	3	11/28/2025	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $773,415

Issue Date FY: 2025 ( Subtotal = $798,023 )
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	002	3	9/22/2025	SUPPLEMENT FOR EXPANSION	$235,673
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	001	3	9/13/2025	NON-COMPETING CONTINUATION	$207,722
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cardiovascular Diseases Research	004	3	9/22/2025	SUPPLEMENT FOR EXPANSION	$35,478
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	003	3	9/22/2025	SUPPLEMENT FOR EXPANSION	$319,150
2025	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	2	10/12/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $798,023

Issue Date FY: 2024 ( Subtotal = $847,310 )
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	002	2	8/30/2024	SUPPLEMENT FOR EXPANSION	$69,434
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cardiovascular Diseases Research	003	2	9/17/2024	SUPPLEMENT FOR EXPANSION	$235,580
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	001	2	8/9/2024	NON-COMPETING CONTINUATION	$542,296
2024	2023	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	1	8/7/2024	NEW	$0
														Subtotal = $847,310

Issue Date FY: 2023 ( Subtotal = $591,259 )
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	1	8/1/2023	NEW	$591,259
														Subtotal = $591,259

Grand Total All Awards = $3,010,007

Top

All Categories

About

Search

Reports

Data Submission

Award Information

ImpleMEntation of a Digital-first care deLiverY model for heart failure in Uganda (MEDLY Uganda)

Award Number: R01HL166585

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2023

PERIOD OF PERFORMANCE END DATE: 07/31/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer