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Linking insufficient sleep with body weight in Black emerging adults.

Award Number: R01HL163804
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/12/2024
PERIOD OF PERFORMANCE END DATE: 02/28/2025

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Linking insufficient sleep with body weight in Black emerging adults. - PROJECT ABSTRACT Compared to peers in other racial groups, Black emerging adults (18-28 years old) have the highest risks of short sleep duration and cardiovascular disease. This increased risk may be partly explained by greater stress levels resulting from race-related stress (experiences of racial discrimination and heightened feelings of vigilance). Insufficient sleep (longer sleep-onset latency, shorter sleep duration, poorer sleep quality and efficiency, lower amounts of slow-wave sleep) may also lead to greater arterial stiffness (hardening of the arteries, reducing their elasticity and ability to expand and contract as blood is pumped through them) and unfavorable hemodynamic characteristics (physical factors such as high blood pressure, pulse pressure, mean arterial pressure, and heart rate that govern blood flood and heart function), which are well-known risk factors for cardiovascular disease. This supplemental project aims to examine cross-sectional associations between measures of insufficient sleep and race-related stress with arterial stiffness and central hemodynamics in 55 Black emerging adults. The parent R01 grant follows a measurement burst design that includes data collection over 3 bursts (baseline, 6-month follow-up and 12-month follow-up), each lasting 7 days. Measures of arterial stiffness and central hemodynamics will be added to the Day 5, in-laboratory protocol prior to measures of resting energy expenditure. Measures of arterial stiffness (via carotid-femoral pulse wave velocity) and central hemodynamics (via pulse wave analysis) will be captured with the SphygmoCor XCEL system. Insufficient sleep variables will be measured with three methods: sleep diary, actigraphy and polysomnography. Race-related stress will be self-reported. Aim 1 will examine cross-sectional associations between insufficient sleep with arterial stiffness and central hemodynamics. Aim 2 will examine cross-sectional associations between race- related stress with arterial stiffness and central hemodynamics. Our overarching hypothesis is that higher amounts of insufficient sleep and race-related stress will be associated with higher arterial stiffness and unfavorable hemodynamic characteristics. This proposed supplemental project is a logical extension of the goals of the parent grant by adding a clinically relevant outcome (measures of arterial stiffness and central hemodynamics) to the parent R01 project which focuses on sleep, race-related stress, and obesity risk. This proposed supplemental project could also have significant public health implications by investigating initial associations between sleep, race-related stress, and well-known risk factors for cardiovascular disease in Black emerging adults.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF NORTH CAROLINA AT GREENSBORO	1000 SPRING GARDEN ST	GREENSBORO	NC	27412	GUILFORD	USA	Cardiovascular Diseases Research	000	2	6/4/2025	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $679,829 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT GREENSBORO	1000 SPRING GARDEN ST	GREENSBORO	NC	27412	GUILFORD	USA	National Center on Sleep Disorders Research	001	2	6/13/2024	NON-COMPETING CONTINUATION	$50,628
2024	2024	UNIVERSITY OF NORTH CAROLINA AT GREENSBORO	1000 SPRING GARDEN ST	GREENSBORO	NC	27412	GUILFORD	USA	Cardiovascular Diseases Research	002	2	9/6/2024	SUPPLEMENT FOR EXPANSION	$59,624
2024	2024	UNIVERSITY OF NORTH CAROLINA AT GREENSBORO	1000 SPRING GARDEN ST	GREENSBORO	NC	27412	GUILFORD	USA	National Center on Sleep Disorders Research	000	2	2/23/2024	NON-COMPETING CONTINUATION	$569,577
														Subtotal = $679,829

Issue Date FY: 2023 ( Subtotal = $625,229 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT GREENSBORO	1000 SPRING GARDEN STREET	GREENSBORO	NC	27412	GUILFORD	USA	National Center on Sleep Disorders Research	000	1	4/28/2023	NEW	$625,229
														Subtotal = $625,229

Grand Total All Awards = $1,305,058

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Linking insufficient sleep with body weight in Black emerging adults.

Award Number: R01HL163804

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/12/2024

PERIOD OF PERFORMANCE END DATE: 02/28/2025

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