Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Smart Cuff: Multi-Parameter Hemodynamic Monitoring via a Single Convenient Device

Award Number: R01HL163691
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/10/2023
PERIOD OF PERFORMANCE END DATE: 01/31/2027

Group Awards By:

View Award Description

Smart Cuff: Multi-Parameter Hemodynamic Monitoring via a Single Convenient Device - PROJECT SUMMARY/ABSTRACT Multi-parameter hemodynamic monitoring is needed to manage surgical and intensive care patients. Monitoring blood pressure (BP), cardiac output (CO), and left ventricular ejection fraction (EF), in particular, permits detection of frequent hypotension and hemodynamic instability, diagnosis of the cause for selecting appropriate therapy, and titration of interventions (e.g., goal-directed therapy). However, measurement of these three hemodynamic variables currently requires multiple devices that are invasive, manual, or specialized. While the oscillometric arm cuff device is non-invasive, automated, and standard, it only estimates BP from the measured cuff pressure waveform via a population average algorithm that does not maintain accuracy over the clinical range. The overall goal of this project is to extend the ubiquitous arm cuff device for accurate and convenient multi- parameter hemodynamic monitoring via smart algorithms. The specific aims are: (1) to build an arm cuff device for recording cuff pressure waveforms; (2) to simultaneously acquire patient data with this and reference devices for algorithm training; (3) to develop and incorporate algorithms for accurately computing BP, CO, and EF from the cuff pressure waveform based on the training data; and (4) to validate the real-time Smart Cuff against reliable reference measurements in patients. The device will be developed to control the cuff pressure and incorporate custom algorithms. The cuff pressure waveform via the device and reference BP, CO, and EF via arterial and pulmonary artery catheters and echocardiography will be recorded before and after clinical interventions in many surgical and intensive care patients. These training data will be analyzed to refine or adapt previous physiologic algorithms and to investigate potentially superior machine learning algorithms for best estimation of the three hemodynamic variables. The final algorithms will be implemented for a real-time device, and the integrated system will be tested against the same reference measurements during clinical interventions but from new patients. Achievement of the specific aims will be followed by a translational project to bring the Smart Cuff to patient care and a research project to extend the device capabilities including addition of automated clinical decision support. Ultimately, these efforts may help in improving patient outcomes and reducing healthcare costs in the near-term.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $647,779 )
2026	2026	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	000	4	4/17/2026	NON-COMPETING CONTINUATION	$647,779
														Subtotal = $647,779

Issue Date FY: 2025 ( Subtotal = $662,986 )
2025	2025	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	000	3	1/24/2025	NON-COMPETING CONTINUATION	$596,688
2025	2025	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	001	3	8/18/2025	NON-COMPETING CONTINUATION	$66,298
														Subtotal = $662,986

Issue Date FY: 2024 ( Subtotal = $653,622 )
2024	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	000	2	2/7/2024	NON-COMPETING CONTINUATION	$600,265
2024	2024	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	001	2	6/20/2024	NON-COMPETING CONTINUATION	$53,357
														Subtotal = $653,622

Issue Date FY: 2023 ( Subtotal = $716,961 )
2023	2023	UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION	4200 FIFTH AVENUE	PITTSBURGH	PA	15260	ALLEGHENY	USA	Cardiovascular Diseases Research	000	1	3/10/2023	NEW	$716,961
														Subtotal = $716,961

Grand Total All Awards = $2,681,348

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Smart Cuff: Multi-Parameter Hemodynamic Monitoring via a Single Convenient Device

Award Number: R01HL163691

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/10/2023

PERIOD OF PERFORMANCE END DATE: 01/31/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer