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Fatty acid-binding proteins sustain endothelial glycolysis and arterial programming in pulmonary arterial hypertension

Award Number: R01HL162794
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Title: Fatty acid-binding proteins sustain endothelial glycolysis and arterial programming in pulmonary arterial hypertension Project Summary Pulmonary arterial hypertension (PAH) is characterized by a progressive increase of pulmonary vascular resistance and obliterative pulmonary vascular remodeling that result in right heart hypertrophy, failure, and premature death. The underlying mechanisms of vascular remodeling and obliterative vascular lesion formation remain unclear. Fatty acid metabolism dysfunction is linked to PAH. However, the mechanistic role of fatty acid metabolism in regulating pulmonary vascular remodeling in the pathogenesis of PAH has not been reported. We hypothesize that endothelial fatty acid-binding proteins 4 and 5 (FABP4-5) regulate endothelial glycolysis and arterial programming through HIF-2a/SOX17 signaling which contributes to severe vascular remodeling in the pathogenesis of PAH. We will 1) define the novel role of endothelial FABP4-5 in the pathogenesis of PAH using multiple transgenic animal models. 2) delineate the cellular and molecular mechanisms that FABP4-5 induces arterial programming and pathogenesis of PAH. Completing our proposed study will provide a novel therapeutic strategy for the effective treatment of PAH in patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $550,748 )
2024	2024	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Lung Diseases Research	001	2	6/24/2024	NON-COMPETING CONTINUATION	$44,958
2024	2024	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Lung Diseases Research	000	2	4/10/2024	NON-COMPETING CONTINUATION	$505,790
														Subtotal = $550,748

Issue Date FY: 2023 ( Subtotal = $575,845 )
2023	2023	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Lung Diseases Research	001	1	5/10/2023	NEW	$0
2023	2023	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Lung Diseases Research	000	1	4/14/2023	NEW	$575,845
														Subtotal = $575,845

Grand Total All Awards = $1,126,593

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Fatty acid-binding proteins sustain endothelial glycolysis and arterial programming in pulmonary arterial hypertension

Award Number: R01HL162794

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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