Wednesday, October 1, 2025 10/1/2025

Pathophysiology of Circadian Rhythm Delayed Sleep Wake Phase Disorder

Award Number: R01HL159647
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2023
PERIOD OF PERFORMANCE END DATE: 07/31/2028

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Pathophysiology of Circadian Rhythm Delayed Sleep Wake Phase Disorder - PROJECT SUMMARY/ABSTRACT Delayed sleep-wake phase disorder (DSWPD) is a circadian rhythm disorder that impacts millions of Americans resulting in adverse health and performance consequences. Patients with DSWPD often obtain insufficient sleep during the work/school week due to difficulties falling asleep and awakening at socially required times, and patients present with excessive sleepiness that significantly interferes with daytime function. Current practice parameter guidelines and metanalyses consider existing treatment strategies for DSWPD, include morning light exposure, evening exogenous melatonin and chronotherapy to be ineffective/“weak” perhaps due to limited understanding of DWSPD pathophysiology and compliance. The overall goal of this proposal is to improve our understanding of DSWPD pathophysiology, which will inform development of new circadian based treatment strategies to improve the health, performance, and well-being of patients with DSWPD. We will conduct ambulatory and baseline circadian phase assessments prior to two in-lab circadian protocols to address our aims: 1) a constant routine protocol to precisely assess the circadian amplitude and phase of central and peripheral circadian rhythms, and 2) a nighttime light exposure protocol to examine cognitive and physiological responses. We will also determine if circadian phase can be accurately predicted in patients with DSWPD using a novel biomarker of circadian phase. Preliminary data from our basic human circadian and clinical trial research set the stage for this proposal. Our overall goal and aims support the NIH Precision Medicine Initiative, the 2021 National Institutes of Health Sleep Research Plan, and the NHLBI Strategic Vision plan.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $670,195 )
2025	2025	THE REGENTS OF THE UNIVERSITY OF COLORADO	3100 MARINE ST	BOULDER	CO	80309	BOULDER	USA	National Center on Sleep Disorders Research	000	3	9/5/2025	NON-COMPETING CONTINUATION	$670,195
														Subtotal = $670,195

Issue Date FY: 2024 ( Subtotal = $662,172 )
2024	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	3100 MARINE ST	BOULDER	CO	80309	BOULDER	USA	National Center on Sleep Disorders Research	000	2	9/6/2024	NON-COMPETING CONTINUATION	$662,172
														Subtotal = $662,172

Issue Date FY: 2023 ( Subtotal = $698,443 )
2023	2023	REGENTS OF THE UNIVERSITY OF COLORADO, THE	3100 MARINE ST STE 481 572 UCB	BOULDER	CO	80309	BOULDER	USA	National Center on Sleep Disorders Research	000	1	8/11/2023	NEW	$698,443
														Subtotal = $698,443

Grand Total All Awards = $2,030,810

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Pathophysiology of Circadian Rhythm Delayed Sleep Wake Phase Disorder

Award Number: R01HL159647

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2023

PERIOD OF PERFORMANCE END DATE: 07/31/2028

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