Friday, October 3, 2025 10/3/2025

Vascular Determinants of Stage B HF among Hispanics: the role of the Heart-Vascular Interaction

Award Number: R01HL158156
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2026

Group Awards By:

View Award Description

Vascular Determinants of Stage B HF among Hispanics: the role of the Heart-Vascular Interaction - Project Summary Aortic stiffness increases markedly with age and is associated with hypertension, heart failure (HF) and accelerated brain aging. Abnormal hemodynamic coupling between left ventricle and aorta contributes to pathogenesis of target organ damage, particularly HF. Hispanics/Latinos have a higher incidence of HF compared to non-Hispanic Whites and present younger with HF with more co-morbidities and a lower left ventricular (LV) ejection fraction. Furthermore, the community-based Echocardiographic Study of Latinos (ECHO-SOL [ES]; R01 PI: Rodriguez) has found that compared to published estimates in non-Hispanic Whites, Hispanics have a higher HF risk factor burden, worse diastolic function and LV stiffness thus signaling Hispanics at high risk for HF with preserved EF (HFpEF). ECHO-SOL 2 (ES2) (PI: Rodriguez) obtained serial echos showing significantly worsening of echo parameters over an average of 4.3 years of follow-up. Mechanism(s) for the susceptibility of Hispanics to HF are not well-accounted for by standard HF risk factors. We hypothesize that vascular function and ventricular-arterial coupling significantly contributes to HF pathogenesis and HF risk in Hispanics. Because the heart and vasculature are intimately coupled, LV stroke volume depends on the important interaction of myocardial contractility with loading conditions from arterial system compliance. There has been no study of comprehensive vascular function and ventricular- arterial coupling assessment concomitant with a detailed echocardiographic exam in Hispanics. Thus, we propose leveraging the resources of HCHS/SOL, ES and ES2 with longitudinal data on cardiac phenotyping as well as clinical, sociocultural, and psychosocial risk factors to comprehensively characterize vascular function in ES participants focusing on key primary pressure-flow phenotypes: carotid-femoral pulse wave velocity, central pulse pressure, characteristic impedance and endothelial function [flow mediated dilatation / hyperemic brachial flow velocities] concomitant with a detailed echocardiographic assessment including 2D, color, spectral / tissue Doppler and speckle tracking. Our application is focused on vascular dysfunction and its interaction / effects on the heart. Impaired mechanical coupling contributes to combination of right and left heart abnormalities limits cardiac output and contributes to the stage B HF (now termed pre-HF) to symptomatic HF, particularly HFpEF. Our goal is to comprehensively describe vascular function pressure-flow relations and its determinants in Hispanics/Latinos. (Aim 1) Then, determine how vascular function relates to cardiac structural and functional abnormalities (including myocardial strain) to test the hypothesis that aortic stiffness impairs mechanical coupling. (Aim 2) Because obtaining an echo exam is a natural component of our primary focus, we will have the benefit of leveraging ~12 years of existing ES and ES2 longitudinal data to identify cardiac trajectories, assess the determinants of each trajectories and the independent association with outcomes such as vascular phenotypes overall mortality and HF. (Aim 3) Lastly, we will link our dataset with other NIH-funded cohorts with existing vascular function data to perform pooled cohort analyses of vascular function of Hispanics/Latinos with non-Hispanic whites and blacks from the Framingham Heart Study and Jackson Heart Study respectively, to identify and address vascular disparities among racial-ethnic minorities. (Aim 4) Our large-scale study represents an innovative and cost-effective (leveraging existing resources) approach to advancing our understanding of the ventricular-vascular interaction on HF progression in an underrepresented and vulnerable population. Identification of Hispanics with pre-HF and abnormal vascular function may help to differentiate those who are at the highest risk for progression to HF, particularly HFpEF. Our proposed study will provide the largest com


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,396,250 )
2025	2025	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cardiovascular Diseases Research	000	4	8/29/2025	NON-COMPETING CONTINUATION	$1,396,250
														Subtotal = $1,396,250

Issue Date FY: 2024 ( Subtotal = $1,194,650 )
2024	2024	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cardiovascular Diseases Research	000	3	8/23/2024	NON-COMPETING CONTINUATION	$1,194,650
														Subtotal = $1,194,650

Issue Date FY: 2023 ( Subtotal = $1,243,724 )
2023	2023	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cardiovascular Diseases Research	000	2	8/29/2023	NON-COMPETING CONTINUATION	$1,243,724
														Subtotal = $1,243,724

Issue Date FY: 2022 ( Subtotal = $1,368,103 )
2022	2022	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Cardiovascular Diseases Research	000	1	8/19/2022	NEW	$1,368,103
														Subtotal = $1,368,103

Grand Total All Awards = $5,202,727

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Vascular Determinants of Stage B HF among Hispanics: the role of the Heart-Vascular Interaction

Award Number: R01HL158156

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer