Wednesday, January 28, 2026 1/28/2026

Neighborhoods and Cardiovascular Risk and Resilience in Rural Communities

Award Number: R01HL157820
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2022
PERIOD OF PERFORMANCE END DATE: 03/31/2027

Group Awards By:

View Award Description

Neighborhoods and Cardiovascular Risk and Resilience in Rural Communities - Project Summary The higher burden of cardiovascular disease (CVD) in rural areas, particularly in Appalachia and the Mississippi Delta is alarming, yet virtually nothing is known about the underlying factors contributing to this rural health penalty. Prior research has shown that neighborhood environments are important drivers of CVD risk and racial/ethnic disparities in CVD; however, this work has been conducted almost exclusively in urban cohorts, leaving ~20% of the population understudied in regard to the #1 cause of mortality in the US. It remains unknown whether traditional features of neighborhood environments (e.g., food access, crime, social cohesion) operate similarly in rural areas to impact CVD risk, and this must be investigated rigorously. There is also an urgent need to better understand the role of more unique features of rural communities, such as geo- spatial isolation of residences, distance between businesses and retail outlets, and social networks operating in these contexts. It is important to characterize these unique rural neighborhood typologies and to investigate which subgroups may be most vulnerable to the cardiovascular health impacts of different neighborhood archetypes. We will examine whether associations are more deleterious among those who are psychosocially vulnerable – those with high levels of childhood trauma or inadequate social support. Finally, factors that contribute to cardiovascular resilience have also been understudied and we have a unique opportunity to investigate the multi-level factors that may contribute to CVD resilience (optimism, purpose in life, resilient coping). Thus, the overarching goal of the proposed study is to: 1) examine the relationship between neighborhood factors and unique neighborhood typologies on cardiovascular health (CVH) in rural communities, 2) determine which groups are most psychosocially vulnerable, and 3) determine whether the impact of adverse neighborhood typologies on CVH and subclinical CVD is mitigated by psychological resilience. The final, exploratory goal of this study is to 4) assess if associations are modified by age, sex, or race/ethnicity. To achieve these goals, we will leverage existing data from the Risk Underlying Rural Areas Longitudinal Study (RURAL) that will recruit 4,600 individuals ages 25-64 from 10 rural counties in Appalachia and the Mississippi Delta of the United States. We will augment this rich rural cohort by linking new data sources (e.g., geo-spatially referenced databases) and creating new measures in order to provide a comprehensive database of indicators of neighborhood physical and social environments. All in all, this work may help provide a more nuanced understanding of the multi- level determinants of both CVD risk and resilience and may help to identify novel levers of intervention to improve cardiovascular health in rural communities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Cardiovascular Diseases Research	000	4	1/13/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $792,691 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Cardiovascular Diseases Research	000	4	4/23/2025	NON-COMPETING CONTINUATION	$713,422
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Cardiovascular Diseases Research	001	4	6/4/2025	NON-COMPETING CONTINUATION	$79,269
														Subtotal = $792,691

Issue Date FY: 2024 ( Subtotal = $776,364 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Cardiovascular Diseases Research	001	3	6/22/2024	NON-COMPETING CONTINUATION	$63,377
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Cardiovascular Diseases Research	000	3	3/8/2024	NON-COMPETING CONTINUATION	$712,987
														Subtotal = $776,364

Issue Date FY: 2023 ( Subtotal = $795,685 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Cardiovascular Diseases Research	000	2	3/20/2023	NON-COMPETING CONTINUATION	$795,685
														Subtotal = $795,685

Issue Date FY: 2022 ( Subtotal = $682,382 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Cardiovascular Diseases Research	000	1	3/25/2022	NEW	$682,382
														Subtotal = $682,382

Grand Total All Awards = $3,047,122

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Neighborhoods and Cardiovascular Risk and Resilience in Rural Communities

Award Number: R01HL157820

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2022

PERIOD OF PERFORMANCE END DATE: 03/31/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer