Wednesday, January 15, 2025 1/15/2025

Early Signs:digital phenotyping to identify digital biomarkers for predicting burnout and cognitive functioning in ED clinicians (Early Signs)

Award Number: R01HL156134
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary The Emergency Department (ED) is a central pillar of the health care system. ED physicians and nurses are exposed to high work-related stressors in addition to disruptive day-night shifts. The well- being of the 150,000 ED clinicians in the U.S. is important for public health with significant downstream effects on the well-being of the 145 million patients that are served every year. Of the 1 million U.S. physicians, 45% are reporting burnout symptoms and the number increases to 70% in ED physicians and up to 82% in ED nurses. Clinician burnout is associated with increased risk for cardiovascular diseases, mortality, medical errors, but also stress-mediated physiological alterations and cognitive decline. Yet, the knowledge about the long-term development of burnout is limited. To effectively intervene, the timely identification of ED clinicians at risk for burnout is a critical prerequisite. This study proposes an innovative approach using digital phenotyping to discover and test Digital Biomarkers as predictors of burnout symptoms and cognitive function. This proposed prospective longitudinal study will chart cognitive functioning and burnout symptom trajectories in a cohort of 350 ED clinicians to inform when, where, and how to intervene. We will use advanced computational methods to extract objective markers for burnout and cognitive decline from video and audio data. Based on our preliminary data, we hypothesize that voice and speech content, head movement, pupil dilation, gaze, and facial landmark features of emotion provide probabilistic information that will allow us to identify digital biomarkers for burnout and cognitive function. We will test the relevance of the discovered digital biomarkers and determine their discriminatory accuracy to distinguish between risk for clinically relevant vs. non-relevant burnout symptoms. We examine the association of digital biomarkers with physiological markers of chronic stress (i.e., hair cortisol concentration). We will also assess the association of digital biomarkers with the long-term job-related stress load of individual ED clinicians such as high ED crowding, patient acuity level, ED staffing, sleep, and shift schedules. This research program aims to deliver an objective, accurate, and reliable digital measure for clinician well-being. Such digital biomarkers will enable more efficient ED clinician self-management and will promote low-threshold prevention strategies. The mental and physical well-being of ED clinicians is of high value to those who work day in and day out to save the lives of others and is the foundation of a well-functioning, high-quality emergency care system.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Cardiovascular Diseases Research	002	3	12/31/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$909,048
2025	2022	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Cardiovascular Diseases Research	001	2	12/31/2024	NON-COMPETING CONTINUATION	-$725,629
2025	2021	THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Cardiovascular Diseases Research	000	1	12/31/2024	NEW	-$183,419
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $717,622 )
2024	2024	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Cardiovascular Diseases Research	000	4	7/30/2024	NON-COMPETING CONTINUATION	$717,622
														Subtotal = $717,622

Issue Date FY: 2023 ( Subtotal = $742,479 )
2023	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Cardiovascular Diseases Research	001	3	8/1/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$742,479
2023	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Cardiovascular Diseases Research	000	2	7/31/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $742,479

Issue Date FY: 2022 ( Subtotal = $725,629 )
2022	2022	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Cardiovascular Diseases Research	000	2	8/12/2022	NON-COMPETING CONTINUATION	$725,629
														Subtotal = $725,629

Issue Date FY: 2021 ( Subtotal = $735,788 )
2021	2021	TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE	630 W 168TH ST FL 4	NEW YORK	NY	10032	NEW YORK	USA	Cardiovascular Diseases Research	000	1	7/12/2021	NEW	$735,788
														Subtotal = $735,788

Grand Total All Awards = $2,921,518

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Early Signs:digital phenotyping to identify digital biomarkers for predicting burnout and cognitive functioning in ED clinicians (Early Signs)

Award Number: R01HL156134

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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