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Reducing maternal prenatal depression to improve child cardiovascular health

Award Number: R01HL155744
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/15/2021
PERIOD OF PERFORMANCE END DATE: 12/31/2025

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Reducing maternal prenatal depression to improve child cardiovascular health - PROJECT SUMMARY/ABSTRACT It is critical to understand risk and protective factors for health to optimize developmental outcomes and inform prevention of poor health behaviors across the lifespan. Research using longitudinal designs, multiple levels of analysis, and experimental clinical trials are needed. Cardiovascular disease (CVD) is the leading cause of death worldwide. The origins of adult CVD begin prenatally: High prenatal maternal depressive symptoms robustly predict offspring CVD risk. However, knowledge on risk and protective factors for CVD for offspring of mothers with high depressive symptoms has been correlational. There is a lack of experimental work using a randomized controlled trial (RCT) design to understand potential mechanisms that contribute to children's CVD risk following exposure to high maternal prenatal depressive symptoms across multiple levels (e.g., maternal and child behaviors, physiology) over time. Although efficacious interventions to diminish depressive symptoms among pregnant women exist, research has not investigated whether reducing prenatal maternal depressive symptoms can reduce offspring cardiovascular risk. The current study proposes to leverage a RCT of an effective psychosocial intervention for prenatal maternal depression to test whether reducing prenatal maternal depressive symptoms improves offspring cardiovascular health at ages 3-4 years. We hypothesize that the prenatal intervention operates by reducing both prenatal and postnatal depressive symptoms to improve child outcomes. This study will identify intervention targets for offspring of mothers with high prenatal depressive symptoms to reduce cardiovascular risk. These goals will be accomplished by building on a RCT (R01MH109662) of an established psychosocial intervention that effectively reduces maternal prenatal depressive symptoms. We propose to leverage this unique opportunity to follow up mothers and children who participated in this RCT to test whether this intervention improves offspring cardiovascular health. This project increases rigor of the existing correlational research by using an experimental RCT design. The following 3 aims will be addressed. Aim 1: To test whether reducing prenatal maternal depressive symptoms improves the quality of food the mother feeds her child, maternal feeding behaviors, and modeling of eating behaviors at 3 years. Aim 2: To test whether reducing prenatal maternal depressive symptoms improves child diet, eating behaviors, sleep, and physical activity at 3 years. Aim 3: To test whether reducing prenatal maternal depressive symptoms reduces child CVD risk at 3 and 4 years, including BMI, waist circumference, body fat, blood pressure, and arterial stiffness. This project will provide the strongest evidence to date for a mechanistic model of prenatal maternal depressive symptoms' influence on child cardiovascular health. Importantly, the project will also provide evidence for whether effective psychosocial interventions to reduce prenatal maternal depressive symptoms should be used to reduce the burden of CVD in the next generation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $619,258 )
2025	2025	UNIVERSITY OF DENVER	2199 S UNIVERSITY BLVD RM 222	DENVER	CO	80210	DENVER	USA	Cardiovascular Diseases Research	001	5	12/23/2024	SUPPLEMENT FOR EXPANSION	$35,272
2025	2025	UNIVERSITY OF DENVER	2199 S UNIVERSITY BLVD RM 222	DENVER	CO	80210	DENVER	USA	Cardiovascular Diseases Research	002	5	12/24/2024	SUPPLEMENT FOR EXPANSION	$33,062
2025	2025	UNIVERSITY OF DENVER	2199 S UNIVERSITY BLVD RM 222	DENVER	CO	80210	DENVER	USA	Cardiovascular Diseases Research	000	5	12/16/2024	NON-COMPETING CONTINUATION	$550,924
														Subtotal = $619,258

Issue Date FY: 2024 ( Subtotal = $754,639 )
2024	2024	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Cardiovascular Diseases Research	002	4	2/2/2024	SUPPLEMENT FOR EXPANSION	$58,937
2024	2024	UNIVERSITY OF DENVER	2199 S UNIVERSITY BLVD RM 222	DENVER	CO	80210	DENVER	USA	Cardiovascular Diseases Research	003	4	6/12/2024	NON-COMPETING CONTINUATION	$52,253
2024	2024	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Cardiovascular Diseases Research	000	4	1/12/2024	NON-COMPETING CONTINUATION	$587,829
2024	2024	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Cardiovascular Diseases Research	001	4	1/20/2024	SUPPLEMENT FOR EXPANSION	$55,620
														Subtotal = $754,639

Issue Date FY: 2023 ( Subtotal = $765,060 )
2023	2023	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Cardiovascular Diseases Research	003	3	9/1/2023	SUPPLEMENT FOR EXPANSION	$30,368
2023	2023	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Cardiovascular Diseases Research	002	3	3/8/2023	NON-COMPETING CONTINUATION	$67,575
2023	2023	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Cardiovascular Diseases Research	001	3	12/22/2022	SUPPLEMENT FOR EXPANSION	$58,937
2023	2023	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Cardiovascular Diseases Research	000	3	12/21/2022	NON-COMPETING CONTINUATION	$608,180
														Subtotal = $765,060

Issue Date FY: 2022 ( Subtotal = $641,532 )
2022	2022	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Cardiovascular Diseases Research	001	2	1/10/2022	SUPPLEMENT FOR EXPANSION	$58,937
2022	2022	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Cardiovascular Diseases Research	002	2	6/24/2022	NON-COMPETING CONTINUATION	$58,258
2022	2022	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Cardiovascular Diseases Research	000	2	1/8/2022	NON-COMPETING CONTINUATION	$524,337
														Subtotal = $641,532

Issue Date FY: 2021 ( Subtotal = $646,268 )
2021	2021	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Cardiovascular Diseases Research	000	1	1/6/2021	NEW	$622,603
2021	2021	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Cardiovascular Diseases Research	002	1	8/27/2021	SUPPLEMENT FOR EXPANSION	$23,665
2021	2021	COLORADO SEMINARY	2199 S UNIVERSITY BLVD	DENVER	CO	80210	DENVER	USA	Cardiovascular Diseases Research	001	1	6/27/2021	NEW	$0
														Subtotal = $646,268

Grand Total All Awards = $3,426,757

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Reducing maternal prenatal depression to improve child cardiovascular health

Award Number: R01HL155744

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/15/2021

PERIOD OF PERFORMANCE END DATE: 12/31/2025

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