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Mycobacterial Lung Diseases in Virginia: sequencing and clinical determinants of relapse and outcome

Award Number: R01HL155547
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2021
PERIOD OF PERFORMANCE END DATE: 12/31/2025

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Mycobacterial Lung Diseases in Virginia: sequencing and clinical determinants of relapse and outcome - PROJECT SUMMARY / ABSTRACT Nontuberculous mycobacterial lung diseases, primarily due to M. avium complex (MAC), is an increasing clinical problem nationwide and now overtakes domestic TB in terms of morbidity and mortality. It is also harder to treat and results in poorer outcomes despite longer drug regimens. In this context NIH issued a notice AI-17-016 to request applications for NTM diseases. Here we present a proposal from the University of Virginia, with collaborators at the Virginia Department of Health and Virginia Tech, that addresses many of the needs that were cited. First, we will perform whole genome sequencing of MAC isolates from all of our state's MAC lung disease patients to discern relapse versus reinfection and the environmental sources of acquisition. Second we will utilize a state-wide cohort of new MAC lung disease patients to correlate clinical outcomes with MAC species, drug susceptibility, serum drug levels, and biofilm bioassay. Innovation includes the use of a state-wide epidemiological cohort, exquisite resolution with extensive preliminary data of whole genome sequencing to discern species and mixed infections, a comprehensive state-wide serum drug monitoring program (as we have done already for TB), and expertise in molecular diagnostics and genotypic-phenotypic correlations. In sum, for this most vexing clinical problem of MAC lung disease we bring to bear extensive preliminary data, unique expertise, innovative technology, cohesive collaborations, and synergistic aims.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $530,209 )
2025	2025	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Lung Diseases Research	000	5	1/9/2025	NON-COMPETING CONTINUATION	$530,209
2025	2024	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Lung Diseases Research	001	4	5/7/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $530,209

Issue Date FY: 2024 ( Subtotal = $578,396 )
2024	2024	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Lung Diseases Research	001	4	6/12/2024	NON-COMPETING CONTINUATION	$47,216
2024	2024	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 EMMET ST N	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Lung Diseases Research	000	4	12/21/2023	NON-COMPETING CONTINUATION	$531,180
														Subtotal = $578,396

Issue Date FY: 2023 ( Subtotal = $673,634 )
2023	2023	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Lung Diseases Research	001	3	3/10/2023	NON-COMPETING CONTINUATION	$67,364
2023	2023	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Lung Diseases Research	000	3	12/21/2022	NON-COMPETING CONTINUATION	$606,270
														Subtotal = $673,634

Issue Date FY: 2022 ( Subtotal = $675,436 )
2022	2022	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Lung Diseases Research	001	2	6/13/2022	NON-COMPETING CONTINUATION	$67,544
2022	2022	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Lung Diseases Research	000	2	12/24/2021	NON-COMPETING CONTINUATION	$607,892
														Subtotal = $675,436

Issue Date FY: 2021 ( Subtotal = $721,114 )
2021	2021	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Lung Diseases Research	001	1	7/3/2021	NEW	$0
2021	2021	RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA	1001 N EMMET ST	CHARLOTTESVILLE	VA	22903	CHARLOTTESVILLE CITY	USA	Lung Diseases Research	000	1	12/22/2020	NEW	$721,114
														Subtotal = $721,114

Grand Total All Awards = $3,178,789

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Mycobacterial Lung Diseases in Virginia: sequencing and clinical determinants of relapse and outcome

Award Number: R01HL155547

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2021

PERIOD OF PERFORMANCE END DATE: 12/31/2025

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