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DORMIR: Determinants, Outcomes, Responses and Markers of Insufficient sleep in Rural-Urban settings

Award Number: R01HL152453
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/05/2020
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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DORMIR: Determinants, Outcomes, Responses and Markers of Insufficient sleep in Rural-Urban settings - Project Summary The widening gap in all-cause and CVD-mortality and morbidity rates in rural and urban America is at an all- time high. Latino/as, the largest minority ethnic group in the U.S., appear to be most affected by rural-urban divide in CVD outcomes, as they are disproportionately burdened by CVD risk (overweight/obesity, hypertension, dyslipidemia, diabetes) and CVD mortality (20%, 2nd leading cause of death among Latino/as) relative to other racial/ethnic groups. Unlike other groups where individuals in rural and urban areas have differing CVD risk, rural and urban Latino/as have similarly high rates of CVD risk. Although, healthy diets/ nutrition, smoking cessation, and regular physical activity are linked to CVD risk, they have not been very effective in reducing the CVD burden among racial/ethnic groups, specifically among Latino/as. Several studies indicate that insufficient sleep (<7hrs./day) explains a significant amount of the CVD burden among Latino/as. Preliminary evidence indicates that insufficient sleep may contribute to the observed CVD burden among Latino/as, as Latino/as have greater odds of experiencing insufficient sleep compared with non-Hispanic whites. Evidence also shows that insufficient sleep, which is associated with potentially life-threatening CVD, is a key modifiable risk factor with great potential to reduce health disparities. However, it is unclear what factors contribute to insufficient sleep (IS) disparities and IS-related CVD burden among rural and urban Latino/as. To address these gaps, we will enroll 525 Latino/as in rural and urban communities to participate in home-based studies using novel mHealth devices. The multidisciplinary team will: 1) identify behavioral, genetic, psychosocial, and environmental factors that are associated with insufficient sleep and IS-related CVD and 2) assess effects of insufficient sleep on CVD risk markers (obesity, blood pressure, lipid profile, and fasting plasma glucose/ HbA1C) and inflammatory risk markers (IL-6, IL-10, and TNF-α). This study will provide multi-level evidence supporting epidemiological findings of greater rates of insufficient sleep among Latino/as, which may explain their disproportionate burden of CVD risk. It will also assess whether and why rural and urban differences in IS exist among Latino/as and how that may lead to IS-related CVD outcomes. These data will provide: 1) the foundation for interventions to mitigate adverse effects of insufficient sleep on CVD health outcomes, 2) evidence to delineate factors underlying insufficient sleep and CVD burden among Latino/as in rural and urban settings, and 3) a possible explanation of behavioral, genetic, environmental and psychosocial determinants of insufficient sleep and related CVD risk factors in rural and urban Latino/as. Findings can lead to actionable clinical, lifestyle, and policy interventions to improve Latino health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	National Center on Sleep Disorders Research	000	5	1/31/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $553,061 )
2024	2024	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	National Center on Sleep Disorders Research	001	5	8/31/2024	NON-COMPETING CONTINUATION	$1
2024	2024	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	National Center on Sleep Disorders Research	002	5	9/26/2024	NON-COMPETING CONTINUATION	$553,060
2024	2023	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	National Center on Sleep Disorders Research	000	4	1/17/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $553,061

Issue Date FY: 2023 ( Subtotal = $718,877 )
2023	2023	UNIVERSITY OF MIAMI	1400 NW 10TH AVE	MIAMI	FL	33136	MIAMI-DADE	USA	National Center on Sleep Disorders Research	004	4	9/9/2023	NON-COMPETING CONTINUATION	$718,877
2023	2022	UNIVERSITY OF MIAMI	1400 NW 10TH AVE	MIAMI	FL	33136	MIAMI-DADE	USA	National Center on Sleep Disorders Research	003	3	9/8/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2023	2022	UNIVERSITY OF MIAMI	1400 NW 10TH AVE	MIAMI	FL	33136	MIAMI-DADE	USA	National Center on Sleep Disorders Research	002	3	11/17/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1,205,716
2023	2021	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	National Center on Sleep Disorders Research	001	2	11/17/2022	NON-COMPETING CONTINUATION	-$816,381
2023	2020	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	National Center on Sleep Disorders Research	000	1	11/17/2022	NEW	-$389,335
														Subtotal = $718,877

Issue Date FY: 2022 ( Subtotal = $811,585 )
2022	2022	UNIVERSITY OF MIAMI	1600 NW 10 AVE	MIAMI	FL	33136	MIAMI-DADE	USA	National Center on Sleep Disorders Research	001	3	9/17/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$811,585
2022	2021	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	National Center on Sleep Disorders Research	000	2	9/15/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $811,585

Issue Date FY: 2021 ( Subtotal = $816,381 )
2021	2021	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	National Center on Sleep Disorders Research	000	2	8/20/2021	NON-COMPETING CONTINUATION	$816,381
														Subtotal = $816,381

Issue Date FY: 2020 ( Subtotal = $847,392 )
2020	2020	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	National Center on Sleep Disorders Research	000	1	9/4/2020	NEW	$847,392
														Subtotal = $847,392

Grand Total All Awards = $3,747,296

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DORMIR: Determinants, Outcomes, Responses and Markers of Insufficient sleep in Rural-Urban settings

Award Number: R01HL152453

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/05/2020

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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